CDKN1B and SIRT6

Number of citations of the paper that reports this interaction (PubMedID 27794562)
56

Data Source:
BioGRID (pull down)

		CDKN1B	SIRT6
Description		cyclin dependent kinase inhibitor 1B	sirtuin 6
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endosome Centrosome Cytosol Cilium Cul4A-RING E3 Ubiquitin Ligase Complex Ciliary Basal Body	Chromosome, Telomeric Region Chromatin Nucleus Nucleoplasm Chromosome Pericentric Heterochromatin Nucleolus Endoplasmic Reticulum Site Of Double-strand Break Site Of DNA Damage Chromosome, Subtelomeric Region
	Molecular Function	Protein Kinase Inhibitor Activity Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Protein Binding Protein Kinase Binding Protein Phosphatase Binding Cyclin-dependent Protein Kinase Regulator Activity Cyclin Binding Ubiquitin Protein Ligase Binding Protein-containing Complex Binding Protein-folding Chaperone Binding Molecular Adaptor Activity Molecular Function Inhibitor Activity Ubiquitin Ligase Activator Activity	DNA Binding Chromatin Binding Damaged DNA Binding Transcription Corepressor Activity RNA Binding NAD+ Poly-ADP-ribosyltransferase Activity Protein Binding Zinc Ion Binding Transferase Activity Acyltransferase Activity Glycosyltransferase Activity Nucleotidyltransferase Activity Histone Deacetylase Activity, NAD-dependent Enzyme Regulator Activity Chromatin DNA Binding Nucleosome Binding Histone H3K9 Deacetylase Activity, Hydrolytic Mechanism NAD-dependent Protein Lysine Deacetylase Activity Histone Deacetylase Regulator Activity Protein Homodimerization Activity Metal Ion Binding Histone H3K9 Deacetylase Activity, NAD-dependent NAD+ Binding Histone H3K18 Deacetylase Activity, NAD-dependent NAD+-protein-arginine ADP-ribosyltransferase Activity DNA Damage Sensor Activity Histone H3K56 Deacetylase Activity, NAD-dependent NAD-dependent Protein Demyristoylase Activity NAD-dependent Protein Depalmitoylase Activity NAD+-protein-lysine ADP-ribosyltransferase Activity TORC2 Complex Binding NAD+-protein Mono-ADP-ribosyltransferase Activity
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G1/S Transition Of Mitotic Cell Cycle Placenta Development Potassium Ion Transport Apoptotic Process Regulation Of Exit From Mitosis Notch Signaling Pathway Regulation Of Mitotic Cell Cycle Heart Development Sensory Perception Of Sound Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Programmed Cell Death Negative Regulation Of Cell Growth DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Cell Migration Positive Regulation Of Microtubule Polymerization Negative Regulation Of Kinase Activity Positive Regulation Of Protein Catabolic Process Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of DNA Replication Negative Regulation Of DNA-templated Transcription Negative Regulation Of Growth Negative Regulation Of Mitotic Cell Cycle Autophagic Cell Death Inner Ear Development Negative Regulation Of Epithelial Cell Proliferation Nuclear Export Regulation Of Cell Cycle Epithelial Cell Proliferation Involved In Prostate Gland Development Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Cellular Response To Antibiotic Cellular Response To Lithium Ion Cellular Senescence Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Lens Fiber Cell Differentiation Regulation Of Cell Cycle G1/S Phase Transition Epithelial Cell Apoptotic Process Negative Regulation Of Cyclin-dependent Protein Kinase Activity Negative Regulation Of Epithelial Cell Apoptotic Process Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Cardiac Muscle Tissue Regeneration Regulation Of G1/S Transition Of Mitotic Cell Cycle	Negative Regulation Of Transcription By RNA Polymerase II Gluconeogenesis Glycolytic Process Regulation Of Gluconeogenesis DNA Repair Regulation Of DNA Repair Base-excision Repair Double-strand Break Repair Chromatin Organization Chromatin Remodeling Protein Deacetylation Protein Import Into Nucleus Inflammatory Response DNA Damage Response Ras Protein Signal Transduction Negative Regulation Of Cell Population Proliferation Determination Of Adult Lifespan Response To UV Transposable Element Silencing Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Lipid Metabolic Process Pericentric Heterochromatin Formation Subtelomeric Heterochromatin Formation Protein Destabilization Positive Regulation Of Insulin Secretion Positive Regulation Of Telomere Maintenance Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Circadian Regulation Of Gene Expression Negative Regulation Of Transcription Elongation By RNA Polymerase II Ketone Biosynthetic Process Negative Regulation Of Protein Import Into Nucleus Glucose Homeostasis Regulation Of Circadian Rhythm Positive Regulation Of Fat Cell Differentiation Negative Regulation Of Gluconeogenesis Positive Regulation Of Gluconeogenesis Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Glycolytic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of D-glucose Import Positive Regulation Of Protein Export From Nucleus Positive Regulation Of Fibroblast Proliferation Regulation Of Protein Secretion Regulation Of Lipid Catabolic Process Protein Delipidation Cardiac Muscle Cell Differentiation Protein Poly-ADP-ribosylation Positive Regulation Of Cold-induced Thermogenesis Negative Regulation Of Protein Localization To Chromatin Positive Regulation Of Protein Localization To Chromatin DNA Repair-dependent Chromatin Remodeling Transcription Pausing By RNA Polymerase II Positive Regulation Of Stem Cell Population Maintenance Positive Regulation Of Chondrocyte Proliferation Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Blood Vessel Branching Positive Regulation Of Vascular Endothelial Cell Proliferation Protein Localization To Site Of Double-strand Break Positive Regulation Of Stem Cell Proliferation Positive Regulation Of Stem Cell Differentiation Negative Regulation Of Cellular Senescence Positive Regulation Of Cellular Senescence Positive Regulation Of Double-strand Break Repair
Pathways		SCF(Skp2)-mediated degradation of p27/p21 AKT phosphorylates targets in the cytosol Senescence-Associated Secretory Phenotype (SASP) DNA Damage/Telomere Stress Induced Senescence RHO GTPases activate CIT Constitutive Signaling by AKT1 E17K in Cancer TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest Cyclin E associated events during G1/S transition Cyclin D associated events in G1 p53-Dependent G1 DNA Damage Response Cyclin A:Cdk2-associated events at S phase entry PTK6 Regulates Cell Cycle FLT3 Signaling FOXO-mediated transcription of cell cycle genes Estrogen-dependent nuclear events downstream of ESR-membrane signaling Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	Pre-NOTCH Transcription and Translation Processing of DNA double-strand break ends
Drugs
Diseases		Prostate cancer
GWAS		Appendicular lean mass ( 33097823) Brain morphology (MOSTest) ( 32665545) Diastolic blood pressure ( 30487518) Mean arterial pressure ( 29403010 30487518) Metabolite levels ( 23823483) Monocyte percentage of white cells ( 32888494) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Plateletcrit ( 32888494) Prostate cancer ( 29892016 31562322) Refractive error ( 32231278) Systemic lupus erythematosus ( 23273568 33272962) Systolic blood pressure ( 30487518) Type 2 diabetes ( 30297969)
Interacting Genes		70 interacting genes: ABL1 AKT1 ARHGDIA ARIH1 CAMK1 CASP8 CCNA1 CCNA2 CCNB1 CCND1 CCND2 CCND3 CCNE2 CDC34 CDK2 CDK3 CDK4 CDK5 CKS1B COP1 COPS5 CUL4A DCLRE1C GRB2 H1-1 H1-5 IRF1 KAT2B KPNA1 KPNA3 KPNA4 KPNA5 KPNA6 LYN MAPK10 MCM7 MTUS2 MYC NUP50 PIN1 PSMB1 RCHY1 RNF123 RNF6 RPS6KA1 SGK1 SIRT6 SKP1 SKP2 SPDYA SRC STMN1 TRAF2 TSC2 UBAC1 UBB UBE2B UBE2D2 UBE2L3 UBE3A UCHL1 WWP1 XPO1 YES1 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ	18 interacting genes: AKT1 CCNDBP1 CDKN1B CHD3 DDB2 ELF5 FAF1 H3C1 HUS1 MUTYH RAD1 SKP2 STUB1 TDG TSPYL2 UBE2D1 UBE3A VIM
Entrez ID		1027	51548
HPRD ID		02867	12093
Ensembl ID		ENSG00000111276	ENSG00000077463
Uniprot IDs		P46527 Q6I9V6	B4DDV3 M0QXA0 M0R1N9 Q8N6T7
PDB IDs		1H27 1JSU 2AST 5UQ3 6ATH 6P8E 6P8F 6P8G 7B5L 7B5M 7B5R 7OR8 7ORG 7ORH 7ORS 7ORT 8BYA 8BYL 8BZO	3K35 3PKI 3PKJ 3ZG6 5MF6 5MFP 5MFZ 5MGN 5X16 5Y2F 6HOY 6QCD 6QCE 6QCH 6QCJ 6XUY 6XV1 6XV6 6XVG 6ZU4 7CL0 7CL1 8AK5 8AK6 8AK7 8AK8 8AK9 8AKA 8AKB 8AKC 8AKD 8AKE 8AKF 8AKG 8BL0 8BL1 8CNM 8CNO 8F86 8G57 8I2B 8OF4 9G7H
Enriched GO Terms of Interacting Partners?		Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Protein Modification Process Nucleus Cell Cycle Phase Transition Nucleoplasm Modification-dependent Protein Catabolic Process Mitotic Cell Cycle Phase Transition Cytosol Post-translational Protein Modification Proteolysis Involved In Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Cytoplasm Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Protein Metabolic Process Macromolecule Catabolic Process Cyclin-dependent Protein Kinase Holoenzyme Complex Protein Modification By Small Protein Conjugation Protein Ubiquitination Regulation Of Cell Cycle Proteolysis Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Protein Domain Specific Binding Cellular Response To Stress Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Modification Process Regulation Of Protein Metabolic Process Intracellular Signal Transduction Catabolic Process Protein Polyubiquitination Protein Localization To Nucleus Transferase Activity NLS-dependent Protein Nuclear Import Complex Regulation Of Macromolecule Metabolic Process Protein Catabolic Process Regulation Of Metabolic Process Ubiquitin-protein Transferase Activity NLS-bearing Protein Import Into Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process Proteasomal Protein Catabolic Process Cyclin-dependent Protein Serine/threonine Kinase Activator Activity Regulation Of DNA Metabolic Process Protein Import Into Nucleus Import Into Nucleus Positive Regulation Of Protein Metabolic Process Positive Regulation Of Mitotic Cell Cycle Ubiquitin Protein Ligase Binding Protein Kinase Binding Phosphoserine Residue Binding	Nucleus Nucleoplasm Protein Polyubiquitination Regulation Of Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Modification Process Regulation Of Post-translational Protein Modification Positive Regulation Of Protein Ubiquitination DNA Metabolic Process Proteasomal Protein Catabolic Process Cellular Response To Stress Positive Regulation Of Protein Metabolic Process DNA Damage Response DNA Repair Checkpoint Clamp Complex Positive Regulation Of Post-translational Protein Modification Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Ubiquitination Protein Catabolic Process Meiotic Cell Cycle Checkpoint Signaling Positive Regulation Of Protein Modification Process Negative Regulation Of TORC1 Signaling Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Reproductive Process Damaged DNA Binding DNA N-glycosylase Activity Protein Modification By Small Protein Conjugation Protein Autoubiquitination Positive Regulation Of Protein Catabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Protein Metabolic Process Cul4A-RING E3 Ubiquitin Ligase Complex Negative Regulation Of TOR Signaling Regulation Of DNA Metabolic Process Ubiquitin-protein Transferase Activity Base-excision Repair, AP Site Formation Regulation Of TORC1 Signaling Post-translational Protein Modification Mammary Gland Epithelial Cell Differentiation Positive Regulation Of Protein Polyubiquitination Positive Regulation Of Metabolic Process Positive Regulation Of DNA Metabolic Process Protein K48-linked Ubiquitination Regulation Of DNA Replication Regulation Of Nucleobase-containing Compound Metabolic Process DNA Modification Regulation Of Protein Polyubiquitination Negative Regulation Of Cell Cycle Response To Stress
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