CDKN1B and CDK3

Number of citations of the paper that reports this interaction (PubMedID 9811456)
0

Data Source:
HPRD (in vivo)

		CDKN1B	CDK3
Description		cyclin dependent kinase inhibitor 1B	cyclin dependent kinase 3
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endosome Centrosome Cytosol Cilium Cul4A-RING E3 Ubiquitin Ligase Complex Ciliary Basal Body	Cyclin-dependent Protein Kinase Holoenzyme Complex Nucleus Cytoplasm
	Molecular Function	Protein Kinase Inhibitor Activity Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Protein Binding Protein Kinase Binding Protein Phosphatase Binding Cyclin-dependent Protein Kinase Regulator Activity Cyclin Binding Ubiquitin Protein Ligase Binding Protein-containing Complex Binding Protein-folding Chaperone Binding Molecular Adaptor Activity Molecular Function Inhibitor Activity Ubiquitin Ligase Activator Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Cyclin Binding Protein Serine Kinase Activity
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G1/S Transition Of Mitotic Cell Cycle Placenta Development Potassium Ion Transport Apoptotic Process Regulation Of Exit From Mitosis Notch Signaling Pathway Regulation Of Mitotic Cell Cycle Heart Development Sensory Perception Of Sound Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Programmed Cell Death Negative Regulation Of Cell Growth DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Cell Migration Positive Regulation Of Microtubule Polymerization Negative Regulation Of Kinase Activity Positive Regulation Of Protein Catabolic Process Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of DNA Replication Negative Regulation Of DNA-templated Transcription Negative Regulation Of Growth Negative Regulation Of Mitotic Cell Cycle Autophagic Cell Death Inner Ear Development Negative Regulation Of Epithelial Cell Proliferation Nuclear Export Regulation Of Cell Cycle Epithelial Cell Proliferation Involved In Prostate Gland Development Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Cellular Response To Antibiotic Cellular Response To Lithium Ion Cellular Senescence Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Lens Fiber Cell Differentiation Regulation Of Cell Cycle G1/S Phase Transition Epithelial Cell Apoptotic Process Negative Regulation Of Cyclin-dependent Protein Kinase Activity Negative Regulation Of Epithelial Cell Apoptotic Process Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Cardiac Muscle Tissue Regeneration Regulation Of G1/S Transition Of Mitotic Cell Cycle	G1/S Transition Of Mitotic Cell Cycle DNA Damage Response Signal Transduction Cell Population Proliferation Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Gene Expression G0 To G1 Transition Negative Regulation Of Notch Signaling Pathway Cell Division
Pathways		SCF(Skp2)-mediated degradation of p27/p21 AKT phosphorylates targets in the cytosol Senescence-Associated Secretory Phenotype (SASP) DNA Damage/Telomere Stress Induced Senescence RHO GTPases activate CIT Constitutive Signaling by AKT1 E17K in Cancer TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest Cyclin E associated events during G1/S transition Cyclin D associated events in G1 p53-Dependent G1 DNA Damage Response Cyclin A:Cdk2-associated events at S phase entry PTK6 Regulates Cell Cycle FLT3 Signaling FOXO-mediated transcription of cell cycle genes Estrogen-dependent nuclear events downstream of ESR-membrane signaling Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
Drugs
Diseases		Prostate cancer
GWAS		Appendicular lean mass ( 33097823) Brain morphology (MOSTest) ( 32665545) Diastolic blood pressure ( 30487518) Mean arterial pressure ( 29403010 30487518) Metabolite levels ( 23823483) Monocyte percentage of white cells ( 32888494) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Plateletcrit ( 32888494) Prostate cancer ( 29892016 31562322) Refractive error ( 32231278) Systemic lupus erythematosus ( 23273568 33272962) Systolic blood pressure ( 30487518) Type 2 diabetes ( 30297969)
Interacting Genes		70 interacting genes: ABL1 AKT1 ARHGDIA ARIH1 CAMK1 CASP8 CCNA1 CCNA2 CCNB1 CCND1 CCND2 CCND3 CCNE2 CDC34 CDK2 CDK3 CDK4 CDK5 CKS1B COP1 COPS5 CUL4A DCLRE1C GRB2 H1-1 H1-5 IRF1 KAT2B KPNA1 KPNA3 KPNA4 KPNA5 KPNA6 LYN MAPK10 MCM7 MTUS2 MYC NUP50 PIN1 PSMB1 RCHY1 RNF123 RNF6 RPS6KA1 SGK1 SIRT6 SKP1 SKP2 SPDYA SRC STMN1 TRAF2 TSC2 UBAC1 UBB UBE2B UBE2D2 UBE2L3 UBE3A UCHL1 WWP1 XPO1 YES1 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ	38 interacting genes: APP CABLES1 CABLES2 CCNA2 CCNC CCND3 CCNE1 CCNE2 CCNH CCNI CDC37 CDKN1A CDKN1B CDKN3 CKS2 E2F1 E2F2 E2F3 FOXP2 FRS2 KIR3DL1 LHX3 LHX4 MEOX2 NEDD4L NELFA OR2G6 OTX2 PAX5 PAX6 PAX8 PPARA RACGAP1 RB1 SPDYE4 STN1 TRIM55 TRIM63
Entrez ID		1027	1018
HPRD ID		02867	00446
Ensembl ID		ENSG00000111276	ENSG00000250506
Uniprot IDs		P46527 Q6I9V6	Q00526
PDB IDs		1H27 1JSU 2AST 5UQ3 6ATH 6P8E 6P8F 6P8G 7B5L 7B5M 7B5R 7OR8 7ORG 7ORH 7ORS 7ORT 8BYA 8BYL 8BZO	7XQK 8H4R
Enriched GO Terms of Interacting Partners?		Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Protein Modification Process Nucleus Cell Cycle Phase Transition Nucleoplasm Modification-dependent Protein Catabolic Process Mitotic Cell Cycle Phase Transition Cytosol Post-translational Protein Modification Proteolysis Involved In Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Cytoplasm Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Protein Metabolic Process Macromolecule Catabolic Process Cyclin-dependent Protein Kinase Holoenzyme Complex Protein Modification By Small Protein Conjugation Protein Ubiquitination Regulation Of Cell Cycle Proteolysis Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Protein Domain Specific Binding Cellular Response To Stress Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Modification Process Regulation Of Protein Metabolic Process Intracellular Signal Transduction Catabolic Process Protein Polyubiquitination Protein Localization To Nucleus Transferase Activity NLS-dependent Protein Nuclear Import Complex Regulation Of Macromolecule Metabolic Process Protein Catabolic Process Regulation Of Metabolic Process Ubiquitin-protein Transferase Activity NLS-bearing Protein Import Into Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process Proteasomal Protein Catabolic Process Cyclin-dependent Protein Serine/threonine Kinase Activator Activity Regulation Of DNA Metabolic Process Protein Import Into Nucleus Import Into Nucleus Positive Regulation Of Protein Metabolic Process Positive Regulation Of Mitotic Cell Cycle Ubiquitin Protein Ligase Binding Protein Kinase Binding Phosphoserine Residue Binding	Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Cyclin-dependent Protein Kinase Holoenzyme Complex Protein Kinase Binding Regulation Of Primary Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Cycle Positive Regulation Of Transcription By RNA Polymerase II Chromatin Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Nucleus DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Sequence-specific DNA Binding Rb-E2F Complex Regulation Of Macromolecule Metabolic Process Regulation Of Mitotic Cell Cycle Regulation Of RNA Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of Metabolic Process DNA-binding Transcription Factor Activity DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cell Division Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Macromolecule Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Cell Population Proliferation Regulation Of Gene Expression Epithelial Cell Apoptotic Process Negative Regulation Of Cardiac Muscle Tissue Regeneration Medial Motor Column Neuron Differentiation Regulation Of Phosphorus Metabolic Process Regulation Of Cell Cycle Phase Transition DNA Binding Positive Regulation Of Mitotic Cell Cycle Cyclin E1-CDK2 Complex Regulation Of Protein Kinase Activity
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