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CD44 and VHL
Number of citations of the paper that reports this interaction (PubMedID
22234250
)
29
Data Source:
BioGRID
(pull down)
CD44
VHL
Description
CD44 molecule (IN blood group)
von Hippel-Lindau tumor suppressor
Image
GO Annotations
Cellular Component
Extracellular Region
Golgi Apparatus
Cytosol
Plasma Membrane
Microvillus
Focal Adhesion
Cell Surface
Membrane
Basolateral Plasma Membrane
Apical Plasma Membrane
Secretory Granule Membrane
Lamellipodium Membrane
Protein-containing Complex
Macrophage Migration Inhibitory Factor Receptor Complex
Cell Projection
Extracellular Exosome
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Endoplasmic Reticulum
Cytosol
Plasma Membrane
Cilium
Microtubule Cytoskeleton
Membrane
Molecular Function
Transmembrane Signaling Receptor Activity
Cytokine Receptor Activity
Protein Binding
Collagen Binding
Hyaluronic Acid Binding
Transcription Elongation Factor Activity
Ubiquitin-protein Transferase Activity
Protein Binding
Enzyme Binding
Molecular Adaptor Activity
Protein Serine/threonine Kinase Binding
DNA-binding Transcription Factor Binding
Ubiquitin-like Ligase-substrate Adaptor Activity
Biological Process
Inflammatory Response
Cell Adhesion
Cell-matrix Adhesion
Anatomical Structure Morphogenesis
Cell Migration
Cytokine-mediated Signaling Pathway
Hyaluronan Catabolic Process
Positive Regulation Of Heterotypic Cell-cell Adhesion
T Cell Activation
Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator
Wound Healing, Spreading Of Cells
Cellular Response To Fibroblast Growth Factor Stimulus
System Development
Cartilage Development
Positive Regulation Of ERK1 And ERK2 Cascade
Monocyte Aggregation
Cell-cell Adhesion
Positive Regulation Of Monocyte Aggregation
Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Regulation Of Lamellipodium Morphogenesis
Negative Regulation Of Transcription By RNA Polymerase II
Cell Morphogenesis
Response To Hypoxia
Regulation Of DNA-templated Transcription
Proteolysis
Negative Regulation Of Cell Population Proliferation
Negative Regulation Of Signal Transduction
Regulation Of Gene Expression
Negative Regulation Of Autophagy
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Gene Expression
Protein Ubiquitination
Negative Regulation Of Transcription Elongation By RNA Polymerase II
Negative Regulation Of Apoptotic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Cell Differentiation
Positive Regulation Of DNA-templated Transcription
Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT
Protein Stabilization
Cellular Response To Hypoxia
Regulation Of Cellular Response To Hypoxia
Negative Regulation Of TORC1 Signaling
Amyloid Fibril Formation
Pathways
Degradation of the extracellular matrix
Cell surface interactions at the vascular wall
Hyaluronan metabolism
Integrin cell surface interactions
Hyaluronan degradation
Neutrophil degranulation
Interferon gamma signaling
Developmental Lineage of Mammary Gland Luminal Epithelial Cells
Developmental Lineage of Mammary Gland Myoepithelial Cells
Developmental Lineage of Mammary Stem Cells
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
SUMOylation of ubiquitinylation proteins
Neddylation
Replication of the SARS-CoV-1 genome
Replication of the SARS-CoV-2 genome
RHOBTB3 ATPase cycle
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Bivatuzumab
Hyaluronic acid
Diseases
Gastric cancer
von Hippel-Lindau syndrome
Congenital polycythemia; Familial erythrocytosis (ECYT)
Renal cell carcinoma
GWAS
Bone mineral density (hip) (
30172743
)
Glycemic traits (pleiotropy) (
31021400
)
Intake of sweets (
31005972
)
Response to Vitamin E supplementation (
22437554
)
Systemic lupus erythematosus (
23273568
26502338
27399966
28714469
)
Thiazide-induced adverse metabolic effects in hypertensive patients (
23400010
)
Total body bone mineral density (
29304378
)
Uterine fibroids (
31649266
)
Vitiligo (
22561518
27723757
)
Bullous pemphigoid (
34011352
)
Hip circumference adjusted for BMI (
34021172
)
Interacting Genes
61 interacting genes:
ABCB1
ABCB5
AKT1
ANK1
ANXA1
ARHGEF1
ARHGEF12
ARNT
CCND2
CD4
CD74
CDK4
CDK6
CDKN2A
CDKN2B
COL14A1
COL1A1
COL1A2
CSK
DMP1
EGFR
EPB41
EPHA2
ERBB4
EZR
FGF2
FGFR4
FN1
FYN
GARS1
GLIS2
GRM1
HBEGF
HMMR
IGFBP3
KDELR2
LATS2
LCK
MADCAM1
MAP2K3
MAP2K5
MDM4
MET
MMP1
MMP7
MMP9
NF2
PDGFRA
PKN1
RAF1
SELE
SPP1
SRC
SRGN
STK11
TGFBR1
TGFBR2
TIAM1
VAV2
VCAN
VHL
172 interacting genes:
ACTB
AHI1
AKT1
ANKEF1
ANKRD11
APP
ARHGEF7
AURKA
BEX2
BEX4
BRCA1
BRD4
CAPN7
CAPZB
CASR
CBR1
CBX1
CBX3
CCNC
CCT3
CCT5
CCT7
CD44
CDC34
CDK1
CDK5RAP3
CDKN2A
CERKL
CHEK2
CLU
COL4A2
COMMD1
CPNE5
CSNK2A1
CUL2
CUL5
DGKI
DIDO1
DNAJA3
DSTN
DVL2
E2F1
EEF1A1
EEF1B2
EGLN1
ELOB
ELOC
EPAS1
EPOR
ERI1
ETFA
FBXO28
FBXO34
FKBP8
FLNA
FLOT1
FN1
GHET1
GPANK1
GPS1
GTF3C2
GUK1
H1-2
H2BC13
H4C16
HDAC1
HDAC2
HDAC3
HIF1A
HIF1AN
HIF3A
HNRNPA2B1
HNRNPD
HSF2BP
HSPA5
HSPA8
IFT88
IKBKB
ITPKC
JADE1
KIF2C
KIF3A
KLF4
KLHL10
LANCL1
MAP1B
MAP1LC3B
MAP1S
MDFI
MRPS9
MSL2
MT-CO2
NCL
NISCH
NR4A1
NR4A2
NR4A3
NSUN5
NSUN7
OTUD6B
PAX2
PDCD5
PFKP
PHB2
PIAS4
PIWIL4
PKP2
PLD1
PLD2
POLR2G
PPP1R13L
PPP5C
PRDX1
PRKCI
PRKG1
PRMT1
PRMT8
PSMC1
PSMC3
RB1CC1
RBPMS
RBPMS2
RBX1
RERE
RHOBTB3
RNF139
RPL21
RPL5
RPS15A
RWDD3
SAP30
SARNP
SAT2
SELENOP
SETDB1
SKP2
SLC2A1
SLC3A2
SMC5
SNRNP200
SON
SP1
SPARC
SPATA22
SPZ1
STAMBP
SUV39H2
TBK1
TDRD7
TEX35
TPT1
TRIM28
TTC3
UBE2D1
UBE2D2
UBE2D3
UBE2I
USP20
USP33
USP9X
UXT
VAPB
VBP1
VRK1
WSB1
YY1AP1
ZBTB17
ZNF197
ZNF200
ZNF512B
ZNF668
ZNF827
Entrez ID
960
7428
HPRD ID
00115
01905
Ensembl ID
ENSG00000026508
ENSG00000134086
Uniprot IDs
P16070
A0A024R2F2
A0A0S2Z4K1
A0A8Q3WL21
P40337
PDB IDs
1POZ
1UUH
2I83
4PZ3
4PZ4
6TXS
1LM8
1LQB
1VCB
3ZRC
3ZRF
3ZTC
3ZTD
3ZUN
4AJY
4AWJ
4B95
4B9K
4BKS
4BKT
4W9C
4W9D
4W9E
4W9F
4W9G
4W9H
4W9I
4W9J
4W9K
4W9L
4WQO
5LLI
5N4W
5NVV
5NVW
5NVX
5NVY
5NVZ
5NW0
5NW1
5NW2
5T35
6BVB
6FMI
6FMJ
6FMK
6GFX
6GFY
6GFZ
6GMN
6GMQ
6GMR
6GMX
6HAX
6HAY
6HR2
6I7Q
6I7R
6R6H
6R7F
6SIS
6ZHC
7CJB
7JTO
7JTP
7KHH
7PI4
7Q2J
7S4E
7Z6L
7Z76
7Z77
7ZNT
8BB2
8BB3
8BB4
8BB5
8BDI
8BDJ
8BDL
8BDM
8BDN
8BDO
8BDS
8BDT
8BDX
8BEB
8C13
8CQE
8CQK
8CQL
8EI3
8EWV
8FY0
8FY1
8FY2
8G1P
8G1Q
8P0F
8PC2
8QJR
8QJS
8QU8
8QVU
8QW6
8QW7
8R5H
8RWZ
8RX0
8VL9
8VLB
8WDK
8YMB
8ZV8
8ZVJ
9BJU
9BOL
9EQJ
9EQM
9IPW
Enriched GO Terms of Interacting Partners
?
Enzyme-linked Receptor Protein Signaling Pathway
Protein Kinase Activity
Regulation Of Intracellular Signal Transduction
Regulation Of Signal Transduction
Signal Transduction
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Regulation Of Cell Motility
Regulation Of Cell Communication
Regulation Of Signaling
Kinase Activity
Regulation Of Locomotion
Regulation Of Cell Population Proliferation
Regulation Of Developmental Process
Regulation Of Cell Migration
Positive Regulation Of Cell Migration
Regulation Of Multicellular Organismal Process
Positive Regulation Of Cell Motility
Positive Regulation Of Signal Transduction
Cell Surface Receptor Signaling Pathway
Protein Tyrosine Kinase Activity
Positive Regulation Of Locomotion
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Cell Differentiation
Intracellular Signal Transduction
Protein Phosphorylation
Animal Organ Development
Developmental Process
Regulation Of Growth
Cellular Developmental Process
Response To Growth Factor
Phosphorylation
Regulation Of Protein Phosphorylation
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Protein Modification Process
ATP Binding
Cellular Response To Growth Factor Stimulus
Regulation Of MAPK Cascade
Regulation Of Multicellular Organismal Development
Regulation Of Cell Differentiation
Regulation Of Phosphorylation
Positive Regulation Of Developmental Process
Cell Migration
Positive Regulation Of Cell Population Proliferation
Positive Regulation Of Growth
Regulation Of Cell Growth
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Regulation Of Phosphorus Metabolic Process
Positive Regulation Of Cell Differentiation
Regulation Of Programmed Cell Death
Nucleus
Regulation Of Primary Metabolic Process
Nucleoplasm
Regulation Of Macromolecule Metabolic Process
Regulation Of Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of DNA-templated Transcription
Regulation Of Macromolecule Biosynthetic Process
Regulation Of RNA Biosynthetic Process
Regulation Of RNA Metabolic Process
Regulation Of Gene Expression
Regulation Of Protein Metabolic Process
Negative Regulation Of Macromolecule Metabolic Process
Cytoplasm
Post-translational Protein Modification
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Negative Regulation Of Metabolic Process
Regulation Of Post-translational Protein Modification
Cellular Response To Stress
Positive Regulation Of Protein Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Apoptotic Process
Positive Regulation Of Metabolic Process
Cytosol
Protein Modification Process
Protein Modification By Small Protein Conjugation
Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Signal Transduction
Regulation Of Programmed Cell Death
Macromolecule Metabolic Process
Protein Metabolic Process
Negative Regulation Of Signaling
Negative Regulation Of Cell Communication
Protein-containing Complex
Negative Regulation Of Intracellular Signal Transduction
Protein Binding
Positive Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of RNA Metabolic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of RNA Biosynthetic Process
Regulation Of Protein Stability
Chromatin Remodeling
Positive Regulation Of Biosynthetic Process
NF-kappaB Binding
Response To Stress
Negative Regulation Of Apoptotic Process
Intracellular Signal Transduction
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Tagcloud (Intersection)
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