VHL and KIF2C

Number of citations of the paper that reports this interaction (PMID 17986458)
3

Data Source:
BioGRID (two hybrid)

		VHL	KIF2C
Gene Name		von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase	kinesin family member 2C
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Mitochondrion Endoplasmic Reticulum Cytosol Membrane Intermediate Filament Cytoskeleton	Chromosome, Centromeric Region Kinetochore Condensed Chromosome Kinetochore Nucleus Cytosol Kinesin Complex Cytoplasmic Microtubule Microtubule Cytoskeleton Membrane Microtubule Plus-end
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Transcription Factor Binding Enzyme Binding Ubiquitin Protein Ligase Activity	Microtubule Motor Activity Protein Binding ATP Binding ATPase Activity Centromeric DNA Binding Microtubule Plus-end Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Cell Morphogenesis Regulation Of Transcription, DNA-templated Proteolysis Negative Regulation Of Cell Proliferation Protein Ubiquitination Negative Regulation Of Apoptotic Process Positive Regulation Of Cell Differentiation Positive Regulation Of Transcription, DNA-templated Protein Stabilization Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Cellular Response To Hypoxia	Mitotic Cell Cycle Microtubule-based Movement Microtubule Depolymerization Mitotic Nuclear Division Mitotic Metaphase Plate Congression Blood Coagulation Metabolic Process Cell Proliferation Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Establishment Or Maintenance Of Microtubule Cytoskeleton Polarity Cell Division Regulation Of Chromosome Segregation
Pathways		Cellular response to hypoxia Antigen processing: Ubiquitination & Proteasome degradation Regulation of Hypoxia-inducible Factor (HIF) by oxygen Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Class I MHC mediated antigen processing & presentation Adaptive Immune System	Mitotic Prometaphase Separation of Sister Chromatids Kinesins Mitotic Anaphase Factors involved in megakaryocyte development and platelet production M Phase Cell Cycle, Mitotic Resolution of Sister Chromatid Cohesion MHC class II antigen presentation Mitotic Metaphase and Anaphase Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		85 interactors: ACTB APP AR AURKA CAPN7 CAPZB CBR1 CBX1 CBX3 CCT3 CD44 CDC34 CHEK2 CLU CSNK2A1 CUL2 CUL5 DGKI DNAJA3 DVL2 E2F1 EEF1B2 EPAS1 FKBP8 FLNA FN1 HDAC1 HDAC2 HDAC3 HIF1A HIF1AN HIF3A HIST1H1C HIST1H2BL HIST4H4 HNRNPA2B1 HNRNPD HSPA5 HSPA8 JADE1 KIF2C KIF3A KLF4 LANCL1 MDFI NCL NR4A1 NR4A2 NR4A3 PDCD5 PLD1 POLR2G PRDX1 PRKCD PRKCI PRMT1 PRMT8 PSMC3 RB1CC1 RBPMS RBPMS2 RBX1 RNF139 RPL21 RPL5 RPS15A SARNP SAT2 SKP2 SLC2A1 SLC3A2 SON SP1 TCEB1 TCEB2 TRIM28 UBE2D1 USP20 USP33 UXT VAPB VBP1 YY1AP1 ZNF197 ZNF512B	8 interactors: APP AURKA CENPH CSNK2B HIST3H3 MAPRE1 VHL ZNF566
Entrez ID		7428	11004
HPRD ID		01905	05172
Ensembl ID			ENSG00000142945
Uniprot IDs		P40337	B7Z6Q6 Q99661
PDB IDs		1LM8 1LQB 1VCB 3ZRC 3ZRF 3ZTC 3ZTD 3ZUN 4AJY 4AWJ 4B95 4B9K	2HEH
Enriched GO Terms of Interacting Partners?		Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Response To Stress Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Gene Expression Cellular Metabolic Process RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of Transcription, DNA-templated RNA Metabolic Process Transcription, DNA-templated Regulation Of Cellular Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Metabolic Process Cellular Response To Stress Positive Regulation Of Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Nucleobase-containing Compound Metabolic Process Cellular Response To Oxygen Levels Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Cell Death Nitrogen Compound Metabolic Process Positive Regulation Of Protein Metabolic Process Blood Coagulation Positive Regulation Of Cellular Protein Metabolic Process Hemostasis Heterocycle Metabolic Process Positive Regulation Of Gene Expression Cellular Aromatic Compound Metabolic Process Regulation Of Apoptotic Process Regulation Of Protein Metabolic Process Transcription From RNA Polymerase II Promoter Regulation Of Body Fluid Levels Biosynthetic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Cell Death Regulation Of Transcription From RNA Polymerase II Promoter Wound Healing Regulation Of Signal Transduction Response To Stimulus	Regulation Of Binding Regulation Of Protein Binding Protein Localization To Cytoskeleton Mitotic Cell Cycle Negative Regulation Of Microtubule Polymerization Or Depolymerization Cell Morphogenesis Regulation Of Microtubule Polymerization Or Depolymerization Developmental Cell Growth Negative Regulation Of Spindle Checkpoint Posttranscriptional Regulation Of Gene Expression Cell Cycle Spindle Assembly Involved In Female Meiosis I Synaptic Growth At Neuromuscular Junction Positive Regulation Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Regulation Of Protein Stability Developmental Growth Involved In Morphogenesis Neuron Projection Morphogenesis Spindle Assembly Involved In Meiosis Collateral Sprouting In Absence Of Injury Positive Regulation Of Microtubule Plus-end Binding Regulation Of Microtubule Cytoskeleton Organization Cell Growth Negative Regulation Of Cytoskeleton Organization Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Spindle Stabilization Regulation Of Microtubule-based Process Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Neuron Projection Development Cellular Component Assembly Cell Projection Morphogenesis Axon Choice Point Recognition Cell Part Morphogenesis Positive Regulation Of Cell Cycle Process Positive Regulation Of Oocyte Maturation Positive Regulation Of Activin Receptor Signaling Pathway Protein Localization To Microtubule Adiponectin-activated Signaling Pathway Meiotic Spindle Organization Protein Localization To Centrosome Neuron Remodeling Mitotic Centrosome Separation Neuron Development Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Female Meiosis I Developmental Growth Positive Regulation Of Oocyte Development
Tagcloud ?		ankyrin attenuates bc belonging binds box collection degenerate elongation elongin hippel inhibiting initially interacting jak lindau motif multifunctional multiprotein participates pol repeat skp1 socs spry stat suppressor von wd	acquisition bioinformatics blocking catastrophe chemoresistance chemoresistant chemosensitive chip clinicopathological contributes deregulation documented establish foxm1 immunohistochemistry implicated invasion knockdown migration mitotic multivariate ovarian paclitaxel prognostic qpcr shorter silencing targets tumorigenesis
Tagcloud (Difference) ?		ankyrin attenuates bc belonging binds box collection degenerate elongation elongin hippel inhibiting initially interacting jak lindau motif multifunctional multiprotein participates pol repeat skp1 socs spry stat suppressor von wd	acquisition bioinformatics blocking catastrophe chemoresistance chemoresistant chemosensitive chip clinicopathological contributes deregulation documented establish foxm1 immunohistochemistry implicated invasion knockdown migration mitotic multivariate ovarian paclitaxel prognostic qpcr shorter silencing targets tumorigenesis
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