CD44 and COL14A1

Number of citations of the paper that reports this interaction (PubMedID 8986622)
0

Data Source:
HPRD (in vitro)

		CD44	COL14A1
Description		CD44 molecule (IN blood group)	collagen type XIV alpha 1 chain
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Golgi Apparatus Cytosol Plasma Membrane Microvillus Focal Adhesion Cell Surface Membrane Basolateral Plasma Membrane Apical Plasma Membrane Secretory Granule Membrane Lamellipodium Membrane Protein-containing Complex Macrophage Migration Inhibitory Factor Receptor Complex Cell Projection Extracellular Exosome	Extracellular Region Collagen Trimer Collagen Type XIV Trimer Interstitial Matrix Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix
	Molecular Function	Transmembrane Signaling Receptor Activity Cytokine Receptor Activity Protein Binding Collagen Binding Hyaluronic Acid Binding	RNA Binding Extracellular Matrix Structural Constituent Collagen Binding Extracellular Matrix Structural Constituent Conferring Tensile Strength Protein-macromolecule Adaptor Activity
	Biological Process	Inflammatory Response Cell Adhesion Cell-matrix Adhesion Anatomical Structure Morphogenesis Cell Migration Cytokine-mediated Signaling Pathway Hyaluronan Catabolic Process Positive Regulation Of Heterotypic Cell-cell Adhesion T Cell Activation Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Wound Healing, Spreading Of Cells Cellular Response To Fibroblast Growth Factor Stimulus System Development Cartilage Development Positive Regulation Of ERK1 And ERK2 Cascade Monocyte Aggregation Cell-cell Adhesion Positive Regulation Of Monocyte Aggregation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Regulation Of Lamellipodium Morphogenesis	Ventricular Cardiac Muscle Tissue Development Cell Adhesion Extracellular Matrix Organization Collagen Fibril Organization Homeostasis Of Number Of Cells Within A Tissue Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Cell-cell Adhesion
Pathways		Degradation of the extracellular matrix Cell surface interactions at the vascular wall Hyaluronan metabolism Integrin cell surface interactions Hyaluronan degradation Neutrophil degranulation Interferon gamma signaling Developmental Lineage of Mammary Gland Luminal Epithelial Cells Developmental Lineage of Mammary Gland Myoepithelial Cells Developmental Lineage of Mammary Stem Cells	Collagen degradation Collagen biosynthesis and modifying enzymes Assembly of collagen fibrils and other multimeric structures Collagen chain trimerization
Drugs		Bivatuzumab Hyaluronic acid
Diseases		Gastric cancer
GWAS		Bone mineral density (hip) ( 30172743) Glycemic traits (pleiotropy) ( 31021400) Intake of sweets ( 31005972) Response to Vitamin E supplementation ( 22437554) Systemic lupus erythematosus ( 23273568 26502338 27399966 28714469) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010) Total body bone mineral density ( 29304378) Uterine fibroids ( 31649266) Vitiligo ( 22561518 27723757)	Adverse response to drug ( 30420678) Appendicular lean mass ( 33097823) Cerebrospinal T-tau levels ( 28247064) Gastritis ( 25317112) Parasitemia in Tripanosoma cruzi seropositivity ( 24324551) Visceral fat ( 30942860)
Interacting Genes		61 interacting genes: ABCB1 ABCB5 AKT1 ANK1 ANXA1 ARHGEF1 ARHGEF12 ARNT CCND2 CD4 CD74 CDK4 CDK6 CDKN2A CDKN2B COL14A1 COL1A1 COL1A2 CSK DMP1 EGFR EPB41 EPHA2 ERBB4 EZR FGF2 FGFR4 FN1 FYN GARS1 GLIS2 GRM1 HBEGF HMMR IGFBP3 KDELR2 LATS2 LCK MADCAM1 MAP2K3 MAP2K5 MDM4 MET MMP1 MMP7 MMP9 NF2 PDGFRA PKN1 RAF1 SELE SPP1 SRC SRGN STK11 TGFBR1 TGFBR2 TIAM1 VAV2 VCAN VHL	5 interacting genes: APP CD44 DCN ENO1 RNF10
Entrez ID		960	7373
HPRD ID		00115	00379
Ensembl ID		ENSG00000026508	ENSG00000187955
Uniprot IDs		P16070	Q05707
PDB IDs		1POZ 1UUH 2I83 4PZ3 4PZ4 6TXS
Enriched GO Terms of Interacting Partners?		Enzyme-linked Receptor Protein Signaling Pathway Protein Kinase Activity Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cell Motility Regulation Of Cell Communication Regulation Of Signaling Kinase Activity Regulation Of Locomotion Regulation Of Cell Population Proliferation Regulation Of Developmental Process Regulation Of Cell Migration Positive Regulation Of Cell Migration Regulation Of Multicellular Organismal Process Positive Regulation Of Cell Motility Positive Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Protein Tyrosine Kinase Activity Positive Regulation Of Locomotion Positive Regulation Of Cell Communication Positive Regulation Of Signaling Cell Differentiation Intracellular Signal Transduction Protein Phosphorylation Animal Organ Development Developmental Process Regulation Of Growth Cellular Developmental Process Response To Growth Factor Phosphorylation Regulation Of Protein Phosphorylation Positive Regulation Of Intracellular Signal Transduction Regulation Of Protein Modification Process ATP Binding Cellular Response To Growth Factor Stimulus Regulation Of MAPK Cascade Regulation Of Multicellular Organismal Development Regulation Of Cell Differentiation Regulation Of Phosphorylation Positive Regulation Of Developmental Process Cell Migration Positive Regulation Of Cell Population Proliferation Positive Regulation Of Growth Regulation Of Cell Growth Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Phosphorus Metabolic Process Positive Regulation Of Cell Differentiation Regulation Of Programmed Cell Death	Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of ATP Metabolic Process Amyloid-beta Complex Regulation Of ATP Metabolic Process Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Regulation Of Purine Nucleotide Metabolic Process Negative Regulation Of Signaling Positive Regulation Of Toll Signaling Pathway Negative Regulation Of Signal Transduction Regulation Of Cellular Response To Stress Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Cell Communication Regulation Of System Process Golgi Lumen Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Cell Surface Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Small Molecule Metabolic Process Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Regulation Of Nervous System Process Microglia Development Regulation Of Intracellular Signal Transduction Positive Regulation Of G Protein-coupled Receptor Internalization Positive Regulation Of Monocyte Aggregation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Macrophage Migration Inhibitory Factor Receptor Complex Monocyte Aggregation Phosphopyruvate Hydratase Complex Phosphopyruvate Hydratase Activity Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Positive Regulation Of ERK1 And ERK2 Cascade Low-density Lipoprotein Particle Mediated Signaling Carbohydrate Derivative Catabolic Process Positive Regulation Of Proteolysis Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?