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VHL and SAT2
Number of citations of the paper that reports this interaction (PubMedID
17558023
)
0
Data Source:
BioGRID
(pull down)
VHL
SAT2
Description
von Hippel-Lindau tumor suppressor
spermidine/spermine N1-acetyltransferase family member 2
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Endoplasmic Reticulum
Cytosol
Plasma Membrane
Cilium
Microtubule Cytoskeleton
Membrane
Cytoplasm
Extracellular Exosome
Molecular Function
Transcription Elongation Factor Activity
Ubiquitin-protein Transferase Activity
Protein Binding
Enzyme Binding
Molecular Adaptor Activity
Protein Serine/threonine Kinase Binding
DNA-binding Transcription Factor Binding
Ubiquitin-like Ligase-substrate Adaptor Activity
Diamine N-acetyltransferase Activity
Protein Binding
N-acetyltransferase Activity
Transferase Activity
Acyltransferase Activity
Acyltransferase Activity, Transferring Groups Other Than Amino-acyl Groups
Identical Protein Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Cell Morphogenesis
Response To Hypoxia
Regulation Of DNA-templated Transcription
Proteolysis
Negative Regulation Of Cell Population Proliferation
Negative Regulation Of Signal Transduction
Regulation Of Gene Expression
Negative Regulation Of Autophagy
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Gene Expression
Protein Ubiquitination
Negative Regulation Of Transcription Elongation By RNA Polymerase II
Negative Regulation Of Apoptotic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Cell Differentiation
Positive Regulation Of DNA-templated Transcription
Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT
Protein Stabilization
Cellular Response To Hypoxia
Regulation Of Cellular Response To Hypoxia
Negative Regulation Of TORC1 Signaling
Amyloid Fibril Formation
Polyamine Biosynthetic Process
Spermidine Acetylation
Spermine Acetylation
Putrescine Acetylation
Nor-spermidine Metabolic Process
Pathways
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
SUMOylation of ubiquitinylation proteins
Neddylation
Replication of the SARS-CoV-1 genome
Replication of the SARS-CoV-2 genome
RHOBTB3 ATPase cycle
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
von Hippel-Lindau syndrome
Congenital polycythemia; Familial erythrocytosis (ECYT)
Renal cell carcinoma
GWAS
Bullous pemphigoid (
34011352
)
Hip circumference adjusted for BMI (
34021172
)
Brain morphology (MOSTest) (
32665545
)
Serum metabolite levels (
33031748
)
Sex hormone-binding globulin levels (
22675492
)
Interacting Genes
172 interacting genes:
ACTB
AHI1
AKT1
ANKEF1
ANKRD11
APP
ARHGEF7
AURKA
BEX2
BEX4
BRCA1
BRD4
CAPN7
CAPZB
CASR
CBR1
CBX1
CBX3
CCNC
CCT3
CCT5
CCT7
CD44
CDC34
CDK1
CDK5RAP3
CDKN2A
CERKL
CHEK2
CLU
COL4A2
COMMD1
CPNE5
CSNK2A1
CUL2
CUL5
DGKI
DIDO1
DNAJA3
DSTN
DVL2
E2F1
EEF1A1
EEF1B2
EGLN1
ELOB
ELOC
EPAS1
EPOR
ERI1
ETFA
FBXO28
FBXO34
FKBP8
FLNA
FLOT1
FN1
GHET1
GPANK1
GPS1
GTF3C2
GUK1
H1-2
H2BC13
H4C16
HDAC1
HDAC2
HDAC3
HIF1A
HIF1AN
HIF3A
HNRNPA2B1
HNRNPD
HSF2BP
HSPA5
HSPA8
IFT88
IKBKB
ITPKC
JADE1
KIF2C
KIF3A
KLF4
KLHL10
LANCL1
MAP1B
MAP1LC3B
MAP1S
MDFI
MRPS9
MSL2
MT-CO2
NCL
NISCH
NR4A1
NR4A2
NR4A3
NSUN5
NSUN7
OTUD6B
PAX2
PDCD5
PFKP
PHB2
PIAS4
PIWIL4
PKP2
PLD1
PLD2
POLR2G
PPP1R13L
PPP5C
PRDX1
PRKCI
PRKG1
PRMT1
PRMT8
PSMC1
PSMC3
RB1CC1
RBPMS
RBPMS2
RBX1
RERE
RHOBTB3
RNF139
RPL21
RPL5
RPS15A
RWDD3
SAP30
SARNP
SAT2
SELENOP
SETDB1
SKP2
SLC2A1
SLC3A2
SMC5
SNRNP200
SON
SP1
SPARC
SPATA22
SPZ1
STAMBP
SUV39H2
TBK1
TDRD7
TEX35
TPT1
TRIM28
TTC3
UBE2D1
UBE2D2
UBE2D3
UBE2I
USP20
USP33
USP9X
UXT
VAPB
VBP1
VRK1
WSB1
YY1AP1
ZBTB17
ZNF197
ZNF200
ZNF512B
ZNF668
ZNF827
5 interacting genes:
ELOC
KAT2B
SAT1
TGFBR1
VHL
Entrez ID
7428
112483
HPRD ID
01905
15296
Ensembl ID
ENSG00000134086
ENSG00000141504
Uniprot IDs
A0A024R2F2
A0A0S2Z4K1
A0A8Q3WL21
P40337
I3L0W4
Q502X4
Q96F10
PDB IDs
1LM8
1LQB
1VCB
3ZRC
3ZRF
3ZTC
3ZTD
3ZUN
4AJY
4AWJ
4B95
4B9K
4BKS
4BKT
4W9C
4W9D
4W9E
4W9F
4W9G
4W9H
4W9I
4W9J
4W9K
4W9L
4WQO
5LLI
5N4W
5NVV
5NVW
5NVX
5NVY
5NVZ
5NW0
5NW1
5NW2
5T35
6BVB
6FMI
6FMJ
6FMK
6GFX
6GFY
6GFZ
6GMN
6GMQ
6GMR
6GMX
6HAX
6HAY
6HR2
6I7Q
6I7R
6R6H
6R7F
6SIS
6ZHC
7CJB
7JTO
7JTP
7KHH
7PI4
7Q2J
7S4E
7Z6L
7Z76
7Z77
7ZNT
8BB2
8BB3
8BB4
8BB5
8BDI
8BDJ
8BDL
8BDM
8BDN
8BDO
8BDS
8BDT
8BDX
8BEB
8C13
8CQE
8CQK
8CQL
8EI3
8EWV
8FY0
8FY1
8FY2
8G1P
8G1Q
8P0F
8PC2
8QJR
8QJS
8QU8
8QVU
8QW6
8QW7
8R5H
8RWZ
8RX0
8VL9
8VLB
8WDK
8YMB
8ZV8
8ZVJ
9BJU
9BOL
9EQJ
9EQM
9IPW
2BEI
2Q4V
Enriched GO Terms of Interacting Partners
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Nucleus
Regulation Of Primary Metabolic Process
Nucleoplasm
Regulation Of Macromolecule Metabolic Process
Regulation Of Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of DNA-templated Transcription
Regulation Of Macromolecule Biosynthetic Process
Regulation Of RNA Biosynthetic Process
Regulation Of RNA Metabolic Process
Regulation Of Gene Expression
Regulation Of Protein Metabolic Process
Negative Regulation Of Macromolecule Metabolic Process
Cytoplasm
Post-translational Protein Modification
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Negative Regulation Of Metabolic Process
Regulation Of Post-translational Protein Modification
Cellular Response To Stress
Positive Regulation Of Protein Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Apoptotic Process
Positive Regulation Of Metabolic Process
Cytosol
Protein Modification Process
Protein Modification By Small Protein Conjugation
Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Signal Transduction
Regulation Of Programmed Cell Death
Macromolecule Metabolic Process
Protein Metabolic Process
Negative Regulation Of Signaling
Negative Regulation Of Cell Communication
Protein-containing Complex
Negative Regulation Of Intracellular Signal Transduction
Protein Binding
Positive Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of RNA Metabolic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of RNA Biosynthetic Process
Regulation Of Protein Stability
Chromatin Remodeling
Positive Regulation Of Biosynthetic Process
NF-kappaB Binding
Response To Stress
Negative Regulation Of Apoptotic Process
Intracellular Signal Transduction
Diamine N-acetyltransferase Activity
Acyltransferase Activity, Transferring Groups Other Than Amino-acyl Groups
Spermidine Acetylation
Putrescine Catabolic Process
Regulation Of Cell Population Proliferation
Spermidine Binding
Protein Modification Process
Modification-dependent Protein Catabolic Process
Proteolysis Involved In Protein Catabolic Process
Ubiquitin-dependent Protein Catabolic Process
Vascular Endothelial Cell Proliferation
Epicardium Morphogenesis
Negative Regulation Of RRNA Processing
Histone H3K9 Acetyltransferase Activity
Polyamine Catabolic Process
Acyltransferase Activity
Catabolic Process
Target-directed MiRNA Degradation
Elongin Complex
Negative Regulation Of Cell Population Proliferation
Positive Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation
Proepicardium Development
Angiogenesis Involved In Coronary Vascular Morphogenesis
Positive Regulation Of Tight Junction Disassembly
Transforming Growth Factor Beta Ligand-receptor Complex
DNA-binding Transcription Factor Binding
N-terminal Peptidyl-lysine Acetylation
Negative Regulation Of Ribosome Biogenesis
Spermidine Metabolic Process
Putrescine Metabolic Process
Positive Regulation Of Biosynthetic Process
Macromolecule Catabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Gene Expression
Positive Regulation Of Mesenchymal Stem Cell Proliferation
Myofibroblast Differentiation
Activin Receptor Complex
Activin Receptor Activity, Type I
Ventricular Compact Myocardium Morphogenesis
Coronary Artery Morphogenesis
Parathyroid Gland Development
Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition
Germ Cell Migration
Transforming Growth Factor Beta Receptor Activity
Trophoblast Cell Migration
Heart Development
Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation
Negative Regulation Of Programmed Cell Death
Transforming Growth Factor Beta Receptor Activity, Type I
Transcription Elongation Factor Activity
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