VHL and CCT3

Number of citations of the paper that reports this interaction (PMID 10635329)
52

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, in vivo)

		VHL	CCT3
Gene Name		von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase	chaperonin containing TCP1, subunit 3 (gamma)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Mitochondrion Endoplasmic Reticulum Cytosol Membrane Intermediate Filament Cytoskeleton	Zona Pellucida Receptor Complex Cytoplasm Cytosol Chaperonin-containing T-complex Cytoskeleton Microtubule Plasma Membrane Cell Body Extracellular Vesicular Exosome
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Transcription Factor Binding Enzyme Binding Ubiquitin Protein Ligase Activity	Protein Binding ATP Binding Poly(A) RNA Binding Unfolded Protein Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Cell Morphogenesis Regulation Of Transcription, DNA-templated Proteolysis Negative Regulation Of Cell Proliferation Protein Ubiquitination Negative Regulation Of Apoptotic Process Positive Regulation Of Cell Differentiation Positive Regulation Of Transcription, DNA-templated Protein Stabilization Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Cellular Response To Hypoxia	Protein Folding Binding Of Sperm To Zona Pellucida Cellular Protein Metabolic Process Pore Complex Assembly 'de Novo' Posttranslational Protein Folding Toxin Transport
Pathways		Cellular response to hypoxia Antigen processing: Ubiquitination & Proteasome degradation Regulation of Hypoxia-inducible Factor (HIF) by oxygen Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Class I MHC mediated antigen processing & presentation Adaptive Immune System	Cargo trafficking to the periciliary membrane Protein folding Organelle biogenesis and maintenance Prefoldin mediated transfer of substrate to CCT/TriC Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding Association of TriC/CCT with target proteins during biosynthesis Chaperonin-mediated protein folding Assembly of the primary cilium BBSome-mediated cargo-targeting to cilium Formation of tubulin folding intermediates by CCT/TriC Folding of actin by CCT/TriC
Drugs
Diseases
GWAS			mean corpuscular hemoglobin concentration ( 20139978) Subcutaneous adipose tissue ( 22589738)
Protein-Protein Interactions		85 interactors: ACTB APP AR AURKA CAPN7 CAPZB CBR1 CBX1 CBX3 CCT3 CD44 CDC34 CHEK2 CLU CSNK2A1 CUL2 CUL5 DGKI DNAJA3 DVL2 E2F1 EEF1B2 EPAS1 FKBP8 FLNA FN1 HDAC1 HDAC2 HDAC3 HIF1A HIF1AN HIF3A HIST1H1C HIST1H2BL HIST4H4 HNRNPA2B1 HNRNPD HSPA5 HSPA8 JADE1 KIF2C KIF3A KLF4 LANCL1 MDFI NCL NR4A1 NR4A2 NR4A3 PDCD5 PLD1 POLR2G PRDX1 PRKCD PRKCI PRMT1 PRMT8 PSMC3 RB1CC1 RBPMS RBPMS2 RBX1 RNF139 RPL21 RPL5 RPS15A SARNP SAT2 SKP2 SLC2A1 SLC3A2 SON SP1 TCEB1 TCEB2 TRIM28 UBE2D1 USP20 USP33 UXT VAPB VBP1 YY1AP1 ZNF197 ZNF512B	13 interactors: EIF2B2 FANCA HNRNPA0 HSPA8 MAPK6 MIPOL1 PAFAH1B2 RAF1 SH3BP4 SSSCA1 VAV2 VHL XRCC6
Entrez ID		7428	7203
HPRD ID		01905	08969
Ensembl ID			ENSG00000163468
Uniprot IDs		P40337	B3KX11 P49368 Q59H77
PDB IDs		1LM8 1LQB 1VCB 3ZRC 3ZRF 3ZTC 3ZTD 3ZUN 4AJY 4AWJ 4B95 4B9K
Enriched GO Terms of Interacting Partners?		Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Response To Stress Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Gene Expression Cellular Metabolic Process RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of Transcription, DNA-templated RNA Metabolic Process Transcription, DNA-templated Regulation Of Cellular Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Metabolic Process Cellular Response To Stress Positive Regulation Of Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Nucleobase-containing Compound Metabolic Process Cellular Response To Oxygen Levels Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Cell Death Nitrogen Compound Metabolic Process Positive Regulation Of Protein Metabolic Process Blood Coagulation Positive Regulation Of Cellular Protein Metabolic Process Hemostasis Heterocycle Metabolic Process Positive Regulation Of Gene Expression Cellular Aromatic Compound Metabolic Process Regulation Of Apoptotic Process Regulation Of Protein Metabolic Process Transcription From RNA Polymerase II Promoter Regulation Of Body Fluid Levels Biosynthetic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Cell Death Regulation Of Transcription From RNA Polymerase II Promoter Wound Healing Regulation Of Signal Transduction Response To Stimulus	Positive Regulation Of Metabolic Process Response To Stress Positive Regulation Of Cellular Metabolic Process Response To Abiotic Stimulus Positive Regulation Of Autophagy Nervous System Development Death-inducing Signaling Complex Assembly Negative Regulation Of Fibril Organization Anatomical Structure Development Response To Stimulus Response To Organic Substance Neurogenesis Axon Guidance Cellular Response To Stimulus Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Autophagy Posttranscriptional Regulation Of Gene Expression Female Gonad Development Cell Morphogenesis Response To Heat Development Of Primary Female Sexual Characteristics Cellular Hyperosmotic Salinity Response Regulation Of Fibril Organization Developmental Process System Development Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Axonogenesis Regulation Of Metabolic Process Clathrin Coat Disassembly Axon Development Cell Morphogenesis Involved In Neuron Differentiation Cellular Response To X-ray Chemotaxis Defense Response Neuron Projection Morphogenesis Multicellular Organismal Development Establishment Of Integrated Proviral Latency Response To Temperature Stimulus Negative Regulation Of Cell Proliferation Platelet Activation Cellular Hyperosmotic Response Hyperosmotic Salinity Response Establishment Of Viral Latency Regulation Of Cell Proliferation Cell Morphogenesis Involved In Differentiation Neurotrophin TRK Receptor Signaling Pathway 3'-UTR-mediated MRNA Stabilization Cellular Response To Stress Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway
Tagcloud ?		ankyrin attenuates bc belonging binds box collection degenerate elongation elongin hippel inhibiting initially interacting jak lindau motif multifunctional multiprotein participates pol repeat skp1 socs spry stat suppressor von wd	adequately cct5 cct7 crc csnk2a2 discover discriminative gna12 hypotheses ifitm1 igfbp3 integrating legacy merely merit mutual outlines pdgfrb plk1 proteomics proxy pruned resultant scheme scoring sized subnetwork subnetworks wealth
Tagcloud (Difference) ?		ankyrin attenuates bc belonging binds box collection degenerate elongation elongin hippel inhibiting initially interacting jak lindau motif multifunctional multiprotein participates pol repeat skp1 socs spry stat suppressor von wd	adequately cct5 cct7 crc csnk2a2 discover discriminative gna12 hypotheses ifitm1 igfbp3 integrating legacy merely merit mutual outlines pdgfrb plk1 proteomics proxy pruned resultant scheme scoring sized subnetwork subnetworks wealth
Tagcloud (Intersection) ?