CD44 and ABCB1

Number of citations of the paper that reports this interaction (PubMedID 26299618)
44

Data Source:
BioGRID (protein complementation assay)

		CD44	ABCB1
Description		CD44 molecule (IN blood group)	ATP binding cassette subfamily B member 1
Image
GO Annotations	Cellular Component	Extracellular Region Golgi Apparatus Cytosol Plasma Membrane Microvillus Focal Adhesion Cell Surface Membrane Basolateral Plasma Membrane Apical Plasma Membrane Secretory Granule Membrane Lamellipodium Membrane Protein-containing Complex Macrophage Migration Inhibitory Factor Receptor Complex Cell Projection Extracellular Exosome	Cytoplasm Plasma Membrane Cell Surface Membrane Apical Plasma Membrane Brush Border Membrane Apical Part Of Cell Extracellular Exosome External Side Of Apical Plasma Membrane
	Molecular Function	Transmembrane Signaling Receptor Activity Cytokine Receptor Activity Protein Binding Collagen Binding Hyaluronic Acid Binding	Nucleotide Binding Protein Binding ATP Binding ABC-type Xenobiotic Transporter Activity Efflux Transmembrane Transporter Activity ATP Hydrolysis Activity Transmembrane Transporter Activity Ubiquitin Protein Ligase Binding ATPase-coupled Transmembrane Transporter Activity Xenobiotic Transmembrane Transporter Activity Carboxylic Acid Transmembrane Transporter Activity Phosphatidylcholine Floppase Activity Phosphatidylethanolamine Flippase Activity Ceramide Floppase Activity ATPase-coupled Intramembrane Lipid Transporter Activity Floppase Activity ABC-type Transporter Activity
	Biological Process	Inflammatory Response Cell Adhesion Cell-matrix Adhesion Anatomical Structure Morphogenesis Cell Migration Cytokine-mediated Signaling Pathway Hyaluronan Catabolic Process Positive Regulation Of Heterotypic Cell-cell Adhesion T Cell Activation Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Wound Healing, Spreading Of Cells Cellular Response To Fibroblast Growth Factor Stimulus System Development Cartilage Development Positive Regulation Of ERK1 And ERK2 Cascade Monocyte Aggregation Cell-cell Adhesion Positive Regulation Of Monocyte Aggregation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Regulation Of Lamellipodium Morphogenesis	G2/M Transition Of Mitotic Cell Cycle Response To Hypoxia Placenta Development Xenobiotic Metabolic Process Lipid Transport Female Pregnancy Lactation Circadian Rhythm Response To Xenobiotic Stimulus Hormone Transport Response To Mycotoxin Response To Nutrient Levels Response To Estradiol Response To Lipopolysaccharide Response To Progesterone Response To Vitamin A Response To Vitamin D Response To Glucagon Maintenance Of Blood-brain Barrier Cellular Response To Mycotoxin Daunorubicin Transport Phospholipid Translocation Response To Cadmium Ion Terpenoid Transport Intestinal Absorption Transmembrane Transport Establishment Of Blood-brain Barrier Transepithelial Transport Cellular Response To External Biotic Stimulus Cellular Response To Lipopolysaccharide Cellular Response To Antibiotic Cellular Response To Alkaloid Cellular Response To Tumor Necrosis Factor Cellular Response To Estradiol Stimulus Cellular Hyperosmotic Salinity Response Response To Dexamethasone Cellular Response To Dexamethasone Stimulus Stem Cell Proliferation Response To Thyroxine Response To Alcohol Response To Antineoplastic Agent Ceramide Translocation Export Across Plasma Membrane Transport Across Blood-brain Barrier Response To L-glutamate Protein Localization To Bicellular Tight Junction Response To Glycoside Negative Regulation Of Sensory Perception Of Pain Cellular Response To Nonylphenol Positive Regulation Of Establishment Of Sertoli Cell Barrier Regulation Of Intestinal Absorption Carboxylic Acid Transmembrane Transport Cellular Response To Borneol Cellular Response To L-glutamate Response To Codeine Response To Quercetin Response To Cyclosporin A Xenobiotic Detoxification By Transmembrane Export Across The Plasma Membrane Xenobiotic Transport Across Blood-brain Barrier Establishment Of Blood-retinal Barrier Positive Regulation Of Response To Drug Regulation Of Chloride Transport
Pathways		Degradation of the extracellular matrix Cell surface interactions at the vascular wall Hyaluronan metabolism Integrin cell surface interactions Hyaluronan degradation Neutrophil degranulation Interferon gamma signaling Developmental Lineage of Mammary Gland Luminal Epithelial Cells Developmental Lineage of Mammary Gland Myoepithelial Cells Developmental Lineage of Mammary Stem Cells	Abacavir transmembrane transport ABC-family proteins mediated transport Atorvastatin ADME Prednisone ADME
Drugs		Bivatuzumab Hyaluronic acid	ATP Medroxyprogesterone acetate Verapamil Roxithromycin Fentanyl Voacamine Elacridar Tesmilifene FM-VP4 Zosuquidar Tariquidar Miltefosine Tocofersolan Hycanthone Concanamycin A Dexverapamil Emopamil Lomerizine Tetrandrine Dofequidar Dexniguldipine ONT-093 HM-30181 Desmethylsertraline Reversin 121 Azvudine
Diseases		Gastric cancer
GWAS		Bone mineral density (hip) ( 30172743) Glycemic traits (pleiotropy) ( 31021400) Intake of sweets ( 31005972) Response to Vitamin E supplementation ( 22437554) Systemic lupus erythematosus ( 23273568 26502338 27399966 28714469) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010) Total body bone mineral density ( 29304378) Uterine fibroids ( 31649266) Vitiligo ( 22561518 27723757)	Appendicular lean mass ( 33097823) Bone mineral density (spine) and age at menarche ( 26312577) Cerebral microbleeds ( 32913026) Gallbladder cancer ( 28274756) Liver enzyme levels (alanine transaminase) ( 33972514) Neurological blood protein biomarker levels ( 31320639) Persistent chemotherapy-induced alopecia in breast cancer ( 32756886)
Interacting Genes		61 interacting genes: ABCB1 ABCB5 AKT1 ANK1 ANXA1 ARHGEF1 ARHGEF12 ARNT CCND2 CD4 CD74 CDK4 CDK6 CDKN2A CDKN2B COL14A1 COL1A1 COL1A2 CSK DMP1 EGFR EPB41 EPHA2 ERBB4 EZR FGF2 FGFR4 FN1 FYN GARS1 GLIS2 GRM1 HBEGF HMMR IGFBP3 KDELR2 LATS2 LCK MADCAM1 MAP2K3 MAP2K5 MDM4 MET MMP1 MMP7 MMP9 NF2 PDGFRA PKN1 RAF1 SELE SPP1 SRC SRGN STK11 TGFBR1 TGFBR2 TIAM1 VAV2 VCAN VHL	14 interacting genes: BCCIP CAV1 CD4 CD44 FBXO21 HAX1 LNX1 MAPKAP1 MAPRE1 NEDD4 PIM1 PSMB8 RNF2 USP7
Entrez ID		960	5243
HPRD ID		00115	01370
Ensembl ID		ENSG00000026508	ENSG00000085563
Uniprot IDs		P16070	A4D1D2 P08183
PDB IDs		1POZ 1UUH 2I83 4PZ3 4PZ4 6TXS	6C0V 6FN1 6FN4 6QEX 7A65 7A69 7A6C 7A6E 7A6F 7O9W 8Y6H 8Y6I 9CR8 9CTC 9CTF 9CTG
Enriched GO Terms of Interacting Partners?		Enzyme-linked Receptor Protein Signaling Pathway Protein Kinase Activity Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cell Motility Regulation Of Cell Communication Regulation Of Signaling Kinase Activity Regulation Of Locomotion Regulation Of Cell Population Proliferation Regulation Of Developmental Process Regulation Of Cell Migration Positive Regulation Of Cell Migration Regulation Of Multicellular Organismal Process Positive Regulation Of Cell Motility Positive Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Protein Tyrosine Kinase Activity Positive Regulation Of Locomotion Positive Regulation Of Cell Communication Positive Regulation Of Signaling Cell Differentiation Intracellular Signal Transduction Protein Phosphorylation Animal Organ Development Developmental Process Regulation Of Growth Cellular Developmental Process Response To Growth Factor Phosphorylation Regulation Of Protein Phosphorylation Positive Regulation Of Intracellular Signal Transduction Regulation Of Protein Modification Process ATP Binding Cellular Response To Growth Factor Stimulus Regulation Of MAPK Cascade Regulation Of Multicellular Organismal Development Regulation Of Cell Differentiation Regulation Of Phosphorylation Positive Regulation Of Developmental Process Cell Migration Positive Regulation Of Cell Population Proliferation Positive Regulation Of Growth Regulation Of Cell Growth Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Phosphorus Metabolic Process Positive Regulation Of Cell Differentiation Regulation Of Programmed Cell Death	Cytokine-mediated Signaling Pathway Response To Nutrient Levels Positive Regulation Of Calcium Ion Transport Into Cytosol Positive Regulation Of Intracellular Signal Transduction Cellular Response To Nutrient Levels Regulation Of Intracellular Signal Transduction Modification-dependent Protein Catabolic Process Ubiquitin-protein Transferase Activity Ubiquitin-dependent Protein Catabolic Process Macromolecule Catabolic Process Ubiquitin Ligase Complex Regulation Of Calcium Ion Transport Into Cytosol Positive Regulation Of Signal Transduction Negative Regulation Of Potassium Ion Transmembrane Transport Proteolysis Involved In Protein Catabolic Process Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Proteolysis Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of Potassium Ion Transport Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Cell Cortex Regulation Of DNA-binding Transcription Factor Activity Mitotic Spindle Pole Establishment Of Mitotic Spindle Orientation Negative Regulation Of Apoptotic Process Negative Regulation Of Signal Transduction Negative Regulation Of Programmed Cell Death Establishment Of Mitotic Spindle Localization Establishment Of Spindle Orientation Regulation Of Cellular Localization Inward Rectifier Potassium Channel Inhibitor Activity Regulation Of Protein Metabolic Process Negative Regulation Of Signaling Negative Regulation Of Cell Communication Interleukin-16 Binding Interleukin-16 Receptor Activity Helper T Cell Enhancement Of Adaptive Immune Response Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Protein Metabolic Process Formation Of Structure Involved In A Symbiotic Process Positive Regulation Of Cardioblast Proliferation Protein Localization To Astral Microtubule Regulation Of Protein Kinase Activity Protein Stabilization Maintenance Of Protein Location In Cell Establishment Of Spindle Localization Macromolecule Metabolic Process Regulation Of Signal Transduction
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