VHL and GUK1

Number of citations of the paper that reports this interaction (PubMedID 35205757)
62

Data Source:
BioGRID (two hybrid)

		VHL	GUK1
Description		von Hippel-Lindau tumor suppressor	guanylate kinase 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Endoplasmic Reticulum Cytosol Plasma Membrane Cilium Microtubule Cytoskeleton Membrane	Photoreceptor Inner Segment Cytoplasm Mitochondrion Cytosol
	Molecular Function	Transcription Elongation Factor Activity Ubiquitin-protein Transferase Activity Protein Binding Enzyme Binding Molecular Adaptor Activity Protein Serine/threonine Kinase Binding DNA-binding Transcription Factor Binding Ubiquitin-like Ligase-substrate Adaptor Activity	Nucleotide Binding GMP Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Cell Morphogenesis Response To Hypoxia Regulation Of DNA-templated Transcription Proteolysis Negative Regulation Of Cell Population Proliferation Negative Regulation Of Signal Transduction Regulation Of Gene Expression Negative Regulation Of Autophagy Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Gene Expression Protein Ubiquitination Negative Regulation Of Transcription Elongation By RNA Polymerase II Negative Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cell Differentiation Positive Regulation Of DNA-templated Transcription Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Protein Stabilization Cellular Response To Hypoxia Regulation Of Cellular Response To Hypoxia Negative Regulation Of TORC1 Signaling Amyloid Fibril Formation	Purine Nucleotide Metabolic Process DGDP Biosynthetic Process Xenobiotic Metabolic Process Nucleobase-containing Small Molecule Interconversion GDP-mannose Metabolic Process Glycoprotein Transport GMP Metabolic Process DGMP Metabolic Process DATP Metabolic Process GDP Biosynthetic Process
Pathways		Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha SUMOylation of ubiquitinylation proteins Neddylation Replication of the SARS-CoV-1 genome Replication of the SARS-CoV-2 genome RHOBTB3 ATPase cycle Antigen processing: Ubiquitination & Proteasome degradation	Interconversion of nucleotide di- and triphosphates Azathioprine ADME
Drugs			Guanosine-5'-Monophosphate
Diseases		von Hippel-Lindau syndrome Congenital polycythemia; Familial erythrocytosis (ECYT) Renal cell carcinoma
GWAS		Bullous pemphigoid ( 34011352) Hip circumference adjusted for BMI ( 34021172)	Coronary artery disease ( 29212778)
Interacting Genes		172 interacting genes: ACTB AHI1 AKT1 ANKEF1 ANKRD11 APP ARHGEF7 AURKA BEX2 BEX4 BRCA1 BRD4 CAPN7 CAPZB CASR CBR1 CBX1 CBX3 CCNC CCT3 CCT5 CCT7 CD44 CDC34 CDK1 CDK5RAP3 CDKN2A CERKL CHEK2 CLU COL4A2 COMMD1 CPNE5 CSNK2A1 CUL2 CUL5 DGKI DIDO1 DNAJA3 DSTN DVL2 E2F1 EEF1A1 EEF1B2 EGLN1 ELOB ELOC EPAS1 EPOR ERI1 ETFA FBXO28 FBXO34 FKBP8 FLNA FLOT1 FN1 GHET1 GPANK1 GPS1 GTF3C2 GUK1 H1-2 H2BC13 H4C16 HDAC1 HDAC2 HDAC3 HIF1A HIF1AN HIF3A HNRNPA2B1 HNRNPD HSF2BP HSPA5 HSPA8 IFT88 IKBKB ITPKC JADE1 KIF2C KIF3A KLF4 KLHL10 LANCL1 MAP1B MAP1LC3B MAP1S MDFI MRPS9 MSL2 MT-CO2 NCL NISCH NR4A1 NR4A2 NR4A3 NSUN5 NSUN7 OTUD6B PAX2 PDCD5 PFKP PHB2 PIAS4 PIWIL4 PKP2 PLD1 PLD2 POLR2G PPP1R13L PPP5C PRDX1 PRKCI PRKG1 PRMT1 PRMT8 PSMC1 PSMC3 RB1CC1 RBPMS RBPMS2 RBX1 RERE RHOBTB3 RNF139 RPL21 RPL5 RPS15A RWDD3 SAP30 SARNP SAT2 SELENOP SETDB1 SKP2 SLC2A1 SLC3A2 SMC5 SNRNP200 SON SP1 SPARC SPATA22 SPZ1 STAMBP SUV39H2 TBK1 TDRD7 TEX35 TPT1 TRIM28 TTC3 UBE2D1 UBE2D2 UBE2D3 UBE2I USP20 USP33 USP9X UXT VAPB VBP1 VRK1 WSB1 YY1AP1 ZBTB17 ZNF197 ZNF200 ZNF512B ZNF668 ZNF827	4 interacting genes: HNRNPD LCOR NLGN3 VHL
Entrez ID		7428	2987
HPRD ID		01905	00755
Ensembl ID		ENSG00000134086	ENSG00000143774
Uniprot IDs		A0A024R2F2 A0A0S2Z4K1 A0A8Q3WL21 P40337	Q16774 Q6IBG8
PDB IDs		1LM8 1LQB 1VCB 3ZRC 3ZRF 3ZTC 3ZTD 3ZUN 4AJY 4AWJ 4B95 4B9K 4BKS 4BKT 4W9C 4W9D 4W9E 4W9F 4W9G 4W9H 4W9I 4W9J 4W9K 4W9L 4WQO 5LLI 5N4W 5NVV 5NVW 5NVX 5NVY 5NVZ 5NW0 5NW1 5NW2 5T35 6BVB 6FMI 6FMJ 6FMK 6GFX 6GFY 6GFZ 6GMN 6GMQ 6GMR 6GMX 6HAX 6HAY 6HR2 6I7Q 6I7R 6R6H 6R7F 6SIS 6ZHC 7CJB 7JTO 7JTP 7KHH 7PI4 7Q2J 7S4E 7Z6L 7Z76 7Z77 7ZNT 8BB2 8BB3 8BB4 8BB5 8BDI 8BDJ 8BDL 8BDM 8BDN 8BDO 8BDS 8BDT 8BDX 8BEB 8C13 8CQE 8CQK 8CQL 8EI3 8EWV 8FY0 8FY1 8FY2 8G1P 8G1Q 8P0F 8PC2 8QJR 8QJS 8QU8 8QVU 8QW6 8QW7 8R5H 8RWZ 8RX0 8VL9 8VLB 8WDK 8YMB 8ZV8 8ZVJ 9BJU 9BOL 9EQJ 9EQM 9IPW	6NUI 8PTS
Enriched GO Terms of Interacting Partners?		Nucleus Regulation Of Primary Metabolic Process Nucleoplasm Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Protein Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Cytoplasm Post-translational Protein Modification Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Metabolic Process Regulation Of Post-translational Protein Modification Cellular Response To Stress Positive Regulation Of Protein Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Apoptotic Process Positive Regulation Of Metabolic Process Cytosol Protein Modification Process Protein Modification By Small Protein Conjugation Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Signal Transduction Regulation Of Programmed Cell Death Macromolecule Metabolic Process Protein Metabolic Process Negative Regulation Of Signaling Negative Regulation Of Cell Communication Protein-containing Complex Negative Regulation Of Intracellular Signal Transduction Protein Binding Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Biosynthetic Process Regulation Of Protein Stability Chromatin Remodeling Positive Regulation Of Biosynthetic Process NF-kappaB Binding Response To Stress Negative Regulation Of Apoptotic Process Intracellular Signal Transduction	Cellular Response To Estradiol Stimulus Hepatocyte Dedifferentiation Cellular Response To Putrescine Response To Estradiol Histone Deacetylase Binding Circadian Regulation Of Translation Rhythmic Synaptic Transmission Symmetric, GABA-ergic, Inhibitory Synapse Response To Rapamycin Positive Regulation Of Telomere Capping Cell Dedifferentiation MCRD-mediated MRNA Stability Complex Response To Sodium Phosphate Minor Groove Of Adenine-thymine-rich DNA Binding Transcription Elongation Factor Activity Establishment Of Mitotic Sister Chromatid Cohesion Cohesin Complex Establishment Of Sister Chromatid Cohesion Mitotic Cohesin Complex Asymmetric, Glutamatergic, Excitatory Synapse Inhibitory Postsynaptic Potential Positive Regulation Of Glutamate Receptor Signaling Pathway Postsynaptic Membrane Assembly Postsynaptic Membrane Organization Presynaptic Membrane Assembly Neuron To Neuron Synapse Presynaptic Membrane Organization CRD-mediated MRNA Stabilization Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Regulation Of Respiratory Gaseous Exchange By Nervous System Process Regulation Of Glutamate Receptor Signaling Pathway Neurexin Family Protein Binding Presynapse Assembly Cellular Response To Nitric Oxide Negative Regulation Of Catabolic Process Regulation Of Telomere Capping Regulation Of Respiratory System Process Neuron Cell-cell Adhesion Histone Methyltransferase Binding Negative Regulation Of RNA Metabolic Process Cellular Response To Reactive Nitrogen Species Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Positive Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Cytoplasmic Translation 3'-UTR-mediated MRNA Destabilization Response To Nitric Oxide Response To Ether Regulation Of Cellular Response To Hypoxia Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT
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