VHL and USP9X

Number of citations of the paper that reports this interaction (PubMedID 27517496)
72

Data Source:
BioGRID (affinity chromatography technology, pull down)

		VHL	USP9X
Description		von Hippel-Lindau tumor suppressor	ubiquitin specific peptidase 9 X-linked
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Endoplasmic Reticulum Cytosol Plasma Membrane Cilium Microtubule Cytoskeleton Membrane	Nucleus Cytoplasm Centrosome Cytosol Cytoskeleton Cilium Membrane Growth Cone Cell Projection
	Molecular Function	Transcription Elongation Factor Activity Ubiquitin-protein Transferase Activity Protein Binding Enzyme Binding Molecular Adaptor Activity Protein Serine/threonine Kinase Binding DNA-binding Transcription Factor Binding Ubiquitin-like Ligase-substrate Adaptor Activity	Cysteine-type Endopeptidase Activity Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity K63-linked Deubiquitinase Activity Co-SMAD Binding Deubiquitinase Activity Molecular Sequestering Activity K11-linked Deubiquitinase Activity K48-linked Deubiquitinase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Cell Morphogenesis Response To Hypoxia Regulation Of DNA-templated Transcription Proteolysis Negative Regulation Of Cell Population Proliferation Negative Regulation Of Signal Transduction Regulation Of Gene Expression Negative Regulation Of Autophagy Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Gene Expression Protein Ubiquitination Negative Regulation Of Transcription Elongation By RNA Polymerase II Negative Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cell Differentiation Positive Regulation Of DNA-templated Transcription Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Protein Stabilization Cellular Response To Hypoxia Regulation Of Cellular Response To Hypoxia Negative Regulation Of TORC1 Signaling Amyloid Fibril Formation	Negative Regulation Of Transcription By RNA Polymerase II Neuron Migration DNA Alkylation Repair Proteolysis Chromosome Segregation Transforming Growth Factor Beta Receptor Signaling Pathway Female Gamete Generation Intracellular Protein Localization Cell Migration Protein Import Into Peroxisome Matrix Protein Import Into Peroxisome Matrix, Receptor Recycling Protein Ubiquitination Protein Deubiquitination BMP Signaling Pathway Regulation Of Protein Stability Positive Regulation Of Protein Binding Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Monoubiquitinated Protein Deubiquitination Regulation Of Circadian Rhythm Rhythmic Process Axon Extension Protein Stabilization Cell Division Cilium Assembly Cytosolic Ciliogenesis Protein K63-linked Deubiquitination Protein Deubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Cilium Assembly Positive Regulation Of TORC2 Signaling Amyloid Fibril Formation
Pathways		Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha SUMOylation of ubiquitinylation proteins Neddylation Replication of the SARS-CoV-1 genome Replication of the SARS-CoV-2 genome RHOBTB3 ATPase cycle Antigen processing: Ubiquitination & Proteasome degradation	Downregulation of SMAD2/3:SMAD4 transcriptional activity Ub-specific processing proteases Synthesis of active ubiquitin: roles of E1 and E2 enzymes RHOU GTPase cycle RHOV GTPase cycle Peroxisomal protein import Peroxisomal protein import Amyloid fiber formation
Drugs
Diseases		von Hippel-Lindau syndrome Congenital polycythemia; Familial erythrocytosis (ECYT) Renal cell carcinoma
GWAS		Bullous pemphigoid ( 34011352) Hip circumference adjusted for BMI ( 34021172)	Migraine ( 27322543)
Interacting Genes		172 interacting genes: ACTB AHI1 AKT1 ANKEF1 ANKRD11 APP ARHGEF7 AURKA BEX2 BEX4 BRCA1 BRD4 CAPN7 CAPZB CASR CBR1 CBX1 CBX3 CCNC CCT3 CCT5 CCT7 CD44 CDC34 CDK1 CDK5RAP3 CDKN2A CERKL CHEK2 CLU COL4A2 COMMD1 CPNE5 CSNK2A1 CUL2 CUL5 DGKI DIDO1 DNAJA3 DSTN DVL2 E2F1 EEF1A1 EEF1B2 EGLN1 ELOB ELOC EPAS1 EPOR ERI1 ETFA FBXO28 FBXO34 FKBP8 FLNA FLOT1 FN1 GHET1 GPANK1 GPS1 GTF3C2 GUK1 H1-2 H2BC13 H4C16 HDAC1 HDAC2 HDAC3 HIF1A HIF1AN HIF3A HNRNPA2B1 HNRNPD HSF2BP HSPA5 HSPA8 IFT88 IKBKB ITPKC JADE1 KIF2C KIF3A KLF4 KLHL10 LANCL1 MAP1B MAP1LC3B MAP1S MDFI MRPS9 MSL2 MT-CO2 NCL NISCH NR4A1 NR4A2 NR4A3 NSUN5 NSUN7 OTUD6B PAX2 PDCD5 PFKP PHB2 PIAS4 PIWIL4 PKP2 PLD1 PLD2 POLR2G PPP1R13L PPP5C PRDX1 PRKCI PRKG1 PRMT1 PRMT8 PSMC1 PSMC3 RB1CC1 RBPMS RBPMS2 RBX1 RERE RHOBTB3 RNF139 RPL21 RPL5 RPS15A RWDD3 SAP30 SARNP SAT2 SELENOP SETDB1 SKP2 SLC2A1 SLC3A2 SMC5 SNRNP200 SON SP1 SPARC SPATA22 SPZ1 STAMBP SUV39H2 TBK1 TDRD7 TEX35 TPT1 TRIM28 TTC3 UBE2D1 UBE2D2 UBE2D3 UBE2I USP20 USP33 USP9X UXT VAPB VBP1 VRK1 WSB1 YY1AP1 ZBTB17 ZNF197 ZNF200 ZNF512B ZNF668 ZNF827	32 interacting genes: AFDN ALDH1A3 BCL9 CDC123 CTNNB1 DCX DDX3X DVL2 ERG GPSM1 MAP3K5 MCL1 NEAT1 NRP1 PEF1 PEX5 PSD4 PTEN RICTOR RNF115 RSPH1 SGTA SMAD2 SMAD4 SMN2 SMURF1 STIL SUMO2 TDRD3 TIAM1 UBC VHL
Entrez ID		7428	8239
HPRD ID		01905	02091
Ensembl ID		ENSG00000134086	ENSG00000124486
Uniprot IDs		A0A024R2F2 A0A0S2Z4K1 A0A8Q3WL21 P40337	A0A994J4R6 A0A994J6S4 Q6P468 Q86X58 Q93008
PDB IDs		1LM8 1LQB 1VCB 3ZRC 3ZRF 3ZTC 3ZTD 3ZUN 4AJY 4AWJ 4B95 4B9K 4BKS 4BKT 4W9C 4W9D 4W9E 4W9F 4W9G 4W9H 4W9I 4W9J 4W9K 4W9L 4WQO 5LLI 5N4W 5NVV 5NVW 5NVX 5NVY 5NVZ 5NW0 5NW1 5NW2 5T35 6BVB 6FMI 6FMJ 6FMK 6GFX 6GFY 6GFZ 6GMN 6GMQ 6GMR 6GMX 6HAX 6HAY 6HR2 6I7Q 6I7R 6R6H 6R7F 6SIS 6ZHC 7CJB 7JTO 7JTP 7KHH 7PI4 7Q2J 7S4E 7Z6L 7Z76 7Z77 7ZNT 8BB2 8BB3 8BB4 8BB5 8BDI 8BDJ 8BDL 8BDM 8BDN 8BDO 8BDS 8BDT 8BDX 8BEB 8C13 8CQE 8CQK 8CQL 8EI3 8EWV 8FY0 8FY1 8FY2 8G1P 8G1Q 8P0F 8PC2 8QJR 8QJS 8QU8 8QVU 8QW6 8QW7 8R5H 8RWZ 8RX0 8VL9 8VLB 8WDK 8YMB 8ZV8 8ZVJ 9BJU 9BOL 9EQJ 9EQM 9IPW	5VBD 5WCH 7YXX 7YXY
Enriched GO Terms of Interacting Partners?		Nucleus Regulation Of Primary Metabolic Process Nucleoplasm Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Protein Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Cytoplasm Post-translational Protein Modification Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Metabolic Process Regulation Of Post-translational Protein Modification Cellular Response To Stress Positive Regulation Of Protein Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Apoptotic Process Positive Regulation Of Metabolic Process Cytosol Protein Modification Process Protein Modification By Small Protein Conjugation Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Signal Transduction Regulation Of Programmed Cell Death Macromolecule Metabolic Process Protein Metabolic Process Negative Regulation Of Signaling Negative Regulation Of Cell Communication Protein-containing Complex Negative Regulation Of Intracellular Signal Transduction Protein Binding Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Biosynthetic Process Regulation Of Protein Stability Chromatin Remodeling Positive Regulation Of Biosynthetic Process NF-kappaB Binding Response To Stress Negative Regulation Of Apoptotic Process Intracellular Signal Transduction	Cytoplasm Cytosol I-SMAD Binding Embryonic Axis Specification Positive Regulation Of Metabolic Process Developmental Process SMAD Binding Regulation Of Epithelial To Mesenchymal Transition Cellular Developmental Process Embryonic Pattern Specification Positive Regulation Of Epithelial To Mesenchymal Transition Tissue Morphogenesis Cell Differentiation Activin Responsive Factor Complex Wnt Signaling Pathway Positive Regulation Of RNA Metabolic Process Axis Specification Positive Regulation Of Macromolecule Metabolic Process R-SMAD Binding Morphogenesis Of An Epithelium Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Cranial Ganglion Development Wnt Signaling Pathway, Planar Cell Polarity Pathway Protein Modification By Small Protein Conjugation Regulation Of Cellular Response To Growth Factor Stimulus Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Signal Transduction Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Cellular Component Assembly SMAD Protein Complex Positive Regulation Of Catabolic Process Heteromeric SMAD Protein Complex Gastrulation Positive Regulation Of Growth Regulation Of Growth Non-canonical Wnt Signaling Pathway Positive Regulation Of Signal Transduction Sympathetic Ganglion Development Positive Regulation Of Developmental Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Protein Ubiquitination Embryonic Morphogenesis Post-translational Protein Modification Embryo Development Ending In Birth Or Egg Hatching Multicellular Organism Development Heart Development Embryonic Foregut Morphogenesis Regulation Of Axonogenesis Neuron Migration
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