CD44 and EPB41

Number of citations of the paper that reports this interaction (PMID 12901833)
5

Data Source:
HPRD (in vitro)

		CD44	EPB41
Gene Name		CD44 molecule (Indian blood group)	erythrocyte membrane protein band 4.1
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion External Side Of Plasma Membrane Cell Surface Basolateral Plasma Membrane Macrophage Migration Inhibitory Factor Receptor Complex Extracellular Vesicular Exosome	Nucleus Golgi Apparatus Plasma Membrane Spectrin Spectrin-associated Cytoskeleton Extrinsic Component Of Membrane Cortical Cytoskeleton Intracellular Membrane-bounded Organelle Protein Complex
	Molecular Function	Hyalurononglucosaminidase Activity Cytokine Receptor Activity Protein Binding Collagen Binding Hyaluronic Acid Binding	Actin Binding Structural Constituent Of Cytoskeleton Protein Binding Calmodulin Binding 1-phosphatidylinositol Binding Spectrin Binding
	Biological Process	Branching Involved In Ureteric Bud Morphogenesis Wound Healing Involved In Inflammatory Response Carbohydrate Metabolic Process Cell-matrix Adhesion Blood Coagulation Pathogenesis Positive Regulation Of Gene Expression Wnt Signaling Pathway Single Organismal Cell-cell Adhesion Cytokine-mediated Signaling Pathway Extracellular Matrix Disassembly Extracellular Matrix Organization Glycosaminoglycan Metabolic Process Hyaluronan Metabolic Process Hyaluronan Catabolic Process Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Heterotypic Cell-cell Adhesion Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Small Molecule Metabolic Process Cellular Response To Fibroblast Growth Factor Stimulus Positive Regulation Of Peptidyl-tyrosine Phosphorylation Leukocyte Migration Cartilage Development Interferon-gamma-mediated Signaling Pathway Branching Involved In Prostate Gland Morphogenesis Positive Regulation Of ERK1 And ERK2 Cascade Monocyte Aggregation Positive Regulation Of Monocyte Aggregation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator	Blood Circulation Actin Cytoskeleton Organization Cortical Actin Cytoskeleton Organization Positive Regulation Of Protein Binding
Pathways		MPS IIIB - Sanfilippo syndrome B Diseases of glycosylation Defective B4GALT7 causes EDS, progeroid type MPS I - Hurler syndrome MPS IX - Natowicz syndrome Defective SLC26A2 causes chondrodysplasias Glycosaminoglycan metabolism Degradation of the extracellular matrix Hyaluronan uptake and degradation Interferon gamma signaling Defective CHST14 causes EDS, musculocontractural type Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective PAPSS2 causes SEMD-PA MPS IIIA - Sanfilippo syndrome A Myoclonic epilepsy of Lafora Glycogen storage diseases Hyaluronan metabolism MPS IIID - Sanfilippo syndrome D Defective CHST6 causes MCDC1 MPS IIIC - Sanfilippo syndrome C Diseases associated with glycosaminoglycan metabolism Mucopolysaccharidoses Defective EXT2 causes exostoses 2 MPS II - Hunter syndrome Interferon Signaling Defective CHST3 causes SEDCJD Cytokine Signaling in Immune system Defective B3GAT3 causes JDSSDHD Defective EXT1 causes exostoses 1, TRPS2 and CHDS Cell surface interactions at the vascular wall MPS IV - Morquio syndrome A MPS IV - Morquio syndrome B Defective CHSY1 causes TPBS Integrin cell surface interactions MPS VII - Sly syndrome Metabolism of carbohydrates MPS VI - Maroteaux-Lamy syndrome
Drugs		Hyaluronan
Diseases
GWAS		Response to Vitamin E supplementation ( 22437554) Systemic lupus erythematosus ( 23273568) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010) Vitiligo ( 22561518)
Protein-Protein Interactions		39 interactors: ANK1 ARHGEF1 ARHGEF12 CD4 CD74 COL14A1 COL1A1 COL1A2 CSK DMP1 EGFR EPB41 ERBB4 EZR FGF2 FN1 FYN GARS HBEGF HMMR IGFBP3 LCK MADCAM1 MMP1 MMP7 MMP9 MSN NF2 PKN1 SELE SPP1 SRC SRGN TGFBR1 TGFBR2 TIAM1 VAV2 VCAN VHL	39 interactors: ACTA1 APP BCAM C2CD2L CASK CD44 CENPJ CLNS1A CRYAB DLG1 DRD2 DRD3 EGFR EIF3G EPB42 FKBP2 GDI1 GYPC KPNA2 MACROD1 MYL1 NPPA NUMA1 PRKCB RWDD2B SEC14L1 SLC4A1 SMAD3 SPTAN1 SPTB SPTBN1 TJP2 TPM1 TUBA4A U2AF1 U2AF2 YWHAB YWHAQ ZCCHC10
Entrez ID		960	2035
HPRD ID		00115	00558
Ensembl ID		ENSG00000026508	ENSG00000159023
Uniprot IDs		P16070	E9PEW9 P11171 Q1WWM3 Q29RX4 Q59F12
PDB IDs		1POZ 1UUH 2I83	1GG3 2RQ1 3QIJ
Enriched GO Terms of Interacting Partners?		Locomotion Cell Migration Cell Motility Movement Of Cell Or Subcellular Component Wound Healing Immune System Process Leukocyte Migration Regulation Of Cellular Component Movement Response To Wounding Anatomical Structure Development Cellular Response To Growth Factor Stimulus Response To Growth Factor Enzyme Linked Receptor Protein Signaling Pathway System Development Developmental Process Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Cell Motility Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Regulation Of Locomotion Cell Differentiation Regulation Of Cell Migration Multicellular Organismal Development Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Activation Extracellular Matrix Disassembly Tissue Development Positive Regulation Of Catalytic Activity Positive Regulation Of Cellular Component Movement Organ Development Platelet Activation Regulation Of Intracellular Signal Transduction Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Positive Regulation Of Cell Migration Anatomical Structure Morphogenesis Positive Regulation Of Cell Motility Response To Stress Cell Adhesion Neurogenesis Positive Regulation Of Locomotion Positive Regulation Of Intracellular Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Kinase Activity ERBB Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Nervous System Development Single Organismal Cell-cell Adhesion	Regulation Of Cellular Component Organization Positive Regulation Of Transport Muscle System Process Cell Development Regulation Of Establishment Of Protein Localization Regulation Of Organelle Organization Muscle Contraction Axonogenesis Movement Of Cell Or Subcellular Component Axon Guidance Axon Development System Development Regulation Of Protein Localization Cellular Component Assembly Regulation Of Cellular Localization Cell Morphogenesis Involved In Neuron Differentiation Cell Differentiation Neuron Projection Morphogenesis Anatomical Structure Development Anatomical Structure Morphogenesis Regulation Of Locomotion Involved In Locomotory Behavior Negative Regulation Of Dopamine Receptor Signaling Pathway Regulation Of Cytoskeleton Organization Response To External Stimulus Cell Morphogenesis Involved In Differentiation Apoptotic Process Regulation Of Systemic Arterial Blood Pressure Regulation Of Actin Cytoskeleton Organization Programmed Cell Death Multicellular Organismal Development Muscle Filament Sliding Actin-myosin Filament Sliding Ion Homeostasis Negative Regulation Of Protein Kinase B Signaling Cell Death Death Cell Morphogenesis Neuron Projection Development Negative Regulation Of Transport Positive Regulation Of Organelle Organization Regulation Of Actin Filament-based Process Chemotaxis Cell Projection Morphogenesis Regulation Of Dopamine Receptor Signaling Pathway Developmental Process Regulation Of Protein Kinase B Signaling Regulation Of Protein Transport Cell Part Morphogenesis Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Cell Projection Organization
Tagcloud ?		acute aml blastic cml elevated hematologic immunosorbent implications kda leukemia lymphoid marker ml monitoring monoclonal myelodysplastic myeloid nearly neoplasias ng phases reached remission scd44 serum slightly soluble syndromes volunteers	ank1 antiglobulin appointment bilirubin cared cytoskeletal cytoskeleton damaged delays discharged e508k epb42 erythrocyte incompatibility kernicterus neurologic newborn parent persisted phototherapy retesting return silico slc4a1 smear spherocytes spta1 sptb ugt1a1
Tagcloud (Difference) ?		acute aml blastic cml elevated hematologic immunosorbent implications kda leukemia lymphoid marker ml monitoring monoclonal myelodysplastic myeloid nearly neoplasias ng phases reached remission scd44 serum slightly soluble syndromes volunteers	ank1 antiglobulin appointment bilirubin cared cytoskeletal cytoskeleton damaged delays discharged e508k epb42 erythrocyte incompatibility kernicterus neurologic newborn parent persisted phototherapy retesting return silico slc4a1 smear spherocytes spta1 sptb ugt1a1
Tagcloud (Intersection) ?