CD44 and ARHGEF1

Number of citations of the paper that reports this interaction (PubMedID 12748184)
0

Data Source:
HPRD (in vivo)

		CD44	ARHGEF1
Description		CD44 molecule (IN blood group)	Rho guanine nucleotide exchange factor 1
Image
GO Annotations	Cellular Component	Extracellular Region Golgi Apparatus Cytosol Plasma Membrane Microvillus Focal Adhesion Cell Surface Membrane Basolateral Plasma Membrane Apical Plasma Membrane Secretory Granule Membrane Lamellipodium Membrane Protein-containing Complex Macrophage Migration Inhibitory Factor Receptor Complex Cell Projection Extracellular Exosome	Cytoplasm Cytosol Plasma Membrane Membrane
	Molecular Function	Transmembrane Signaling Receptor Activity Cytokine Receptor Activity Protein Binding Collagen Binding Hyaluronic Acid Binding	G Protein-coupled Receptor Binding RNA Binding Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding
	Biological Process	Inflammatory Response Cell Adhesion Cell-matrix Adhesion Anatomical Structure Morphogenesis Cell Migration Cytokine-mediated Signaling Pathway Hyaluronan Catabolic Process Positive Regulation Of Heterotypic Cell-cell Adhesion T Cell Activation Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Wound Healing, Spreading Of Cells Cellular Response To Fibroblast Growth Factor Stimulus System Development Cartilage Development Positive Regulation Of ERK1 And ERK2 Cascade Monocyte Aggregation Cell-cell Adhesion Positive Regulation Of Monocyte Aggregation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Regulation Of Lamellipodium Morphogenesis	G Protein-coupled Receptor Signaling Pathway Rho Protein Signal Transduction Regulation Of Small GTPase Mediated Signal Transduction Rho-activating G Protein-coupled Receptor Signaling Pathway
Pathways		Degradation of the extracellular matrix Cell surface interactions at the vascular wall Hyaluronan metabolism Integrin cell surface interactions Hyaluronan degradation Neutrophil degranulation Interferon gamma signaling Developmental Lineage of Mammary Gland Luminal Epithelial Cells Developmental Lineage of Mammary Gland Myoepithelial Cells Developmental Lineage of Mammary Stem Cells	NRAGE signals death through JNK G alpha (12/13) signalling events RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle
Drugs		Bivatuzumab Hyaluronic acid
Diseases		Gastric cancer
GWAS		Bone mineral density (hip) ( 30172743) Glycemic traits (pleiotropy) ( 31021400) Intake of sweets ( 31005972) Response to Vitamin E supplementation ( 22437554) Systemic lupus erythematosus ( 23273568 26502338 27399966 28714469) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010) Total body bone mineral density ( 29304378) Uterine fibroids ( 31649266) Vitiligo ( 22561518 27723757)	Brain morphology (MOSTest) ( 32665545) Hallux valgus ( 32131869)
Interacting Genes		61 interacting genes: ABCB1 ABCB5 AKT1 ANK1 ANXA1 ARHGEF1 ARHGEF12 ARNT CCND2 CD4 CD74 CDK4 CDK6 CDKN2A CDKN2B COL14A1 COL1A1 COL1A2 CSK DMP1 EGFR EPB41 EPHA2 ERBB4 EZR FGF2 FGFR4 FN1 FYN GARS1 GLIS2 GRM1 HBEGF HMMR IGFBP3 KDELR2 LATS2 LCK MADCAM1 MAP2K3 MAP2K5 MDM4 MET MMP1 MMP7 MMP9 NF2 PDGFRA PKN1 RAF1 SELE SPP1 SRC SRGN STK11 TGFBR1 TGFBR2 TIAM1 VAV2 VCAN VHL	12 interacting genes: ATR CD44 CNKSR1 CSNK1E GNA13 HRAS PRKCA RAP1A RHOA RNF10 SREBF2 TCF4
Entrez ID		960	9138
HPRD ID		00115	03511
Ensembl ID		ENSG00000026508	ENSG00000076928
Uniprot IDs		P16070	M0QZR4 Q92888
PDB IDs		1POZ 1UUH 2I83 4PZ3 4PZ4 6TXS	1IAP 1SHZ 3AB3 3ODO 3ODW 3ODX 3P6A
Enriched GO Terms of Interacting Partners?		Enzyme-linked Receptor Protein Signaling Pathway Protein Kinase Activity Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cell Motility Regulation Of Cell Communication Regulation Of Signaling Kinase Activity Regulation Of Locomotion Regulation Of Cell Population Proliferation Regulation Of Developmental Process Regulation Of Cell Migration Positive Regulation Of Cell Migration Regulation Of Multicellular Organismal Process Positive Regulation Of Cell Motility Positive Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Protein Tyrosine Kinase Activity Positive Regulation Of Locomotion Positive Regulation Of Cell Communication Positive Regulation Of Signaling Cell Differentiation Intracellular Signal Transduction Protein Phosphorylation Animal Organ Development Developmental Process Regulation Of Growth Cellular Developmental Process Response To Growth Factor Phosphorylation Regulation Of Protein Phosphorylation Positive Regulation Of Intracellular Signal Transduction Regulation Of Protein Modification Process ATP Binding Cellular Response To Growth Factor Stimulus Regulation Of MAPK Cascade Regulation Of Multicellular Organismal Development Regulation Of Cell Differentiation Regulation Of Phosphorylation Positive Regulation Of Developmental Process Cell Migration Positive Regulation Of Cell Population Proliferation Positive Regulation Of Growth Regulation Of Cell Growth Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Phosphorus Metabolic Process Positive Regulation Of Cell Differentiation Regulation Of Programmed Cell Death	G Protein Activity Signal Transduction Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Intracellular Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Cell Junction Assembly Intracellular Signal Transduction Positive Regulation Of Cell Communication Regulation Of Signal Transduction Small GTPase-mediated Signal Transduction Positive Regulation Of Signaling Positive Regulation Of Intracellular Signal Transduction Nucleotide Binding Positive Regulation Of Signal Transduction GTPase Activity Regulation Of Cell Communication Regulation Of Signaling Membrane Disassembly Nuclear Membrane Disassembly Regulation Of ERK1 And ERK2 Cascade Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane GTP Binding Intracellular Signaling Cassette Wound Healing, Spreading Of Cells Cellular Response To Gamma Radiation Regulation Of Receptor Localization To Synapse Regulation Of Protein Localization To Synapse Positive Regulation Of MAPK Cascade Regulation Of Protein Localization Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Cellular Component Biogenesis Cellular Response To Nerve Growth Factor Stimulus Regulation Of Developmental Process Glutamatergic Synapse Response To Nerve Growth Factor Regulation Of Cellular Component Organization Nuclear Membrane Organization Non-canonical Wnt Signaling Pathway Response To Gamma Radiation Positive Regulation Of Cellular Component Organization Angiotensin-mediated Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Mitotic Cleavage Furrow Formation E-box Binding Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of MAPK Cascade Cellular Response To Growth Factor Stimulus Regulation Of Cell Projection Organization Positive Regulation Of MiRNA Metabolic Process Rho Protein Signal Transduction
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