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VHL and NR4A1
Number of citations of the paper that reports this interaction (PubMedID
18305400
)
40
Data Source:
HPRD
(in vivo)
VHL
NR4A1
Description
von Hippel-Lindau tumor suppressor
nuclear receptor subfamily 4 group A member 1
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Endoplasmic Reticulum
Cytosol
Plasma Membrane
Cilium
Microtubule Cytoskeleton
Membrane
Chromatin
Fibrillar Center
Nucleus
Nucleoplasm
Transcription Regulator Complex
Cytoplasm
Mitochondrion
Cytosol
Nuclear Speck
Nuclear Membrane
Molecular Function
Transcription Elongation Factor Activity
Ubiquitin-protein Transferase Activity
Protein Binding
Enzyme Binding
Molecular Adaptor Activity
Protein Serine/threonine Kinase Binding
DNA-binding Transcription Factor Binding
Ubiquitin-like Ligase-substrate Adaptor Activity
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
Lipopolysaccharide Binding
DNA Binding
Double-stranded DNA Binding
DNA-binding Transcription Factor Activity
Nuclear Receptor Activity
Protein Binding
Zinc Ion Binding
Nuclear Glucocorticoid Receptor Binding
Identical Protein Binding
Sequence-specific DNA Binding
Metal Ion Binding
Protein Heterodimerization Activity
Sequence-specific Double-stranded DNA Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Cell Morphogenesis
Response To Hypoxia
Regulation Of DNA-templated Transcription
Proteolysis
Negative Regulation Of Cell Population Proliferation
Negative Regulation Of Signal Transduction
Regulation Of Gene Expression
Negative Regulation Of Autophagy
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Gene Expression
Protein Ubiquitination
Negative Regulation Of Transcription Elongation By RNA Polymerase II
Negative Regulation Of Apoptotic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Cell Differentiation
Positive Regulation Of DNA-templated Transcription
Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT
Protein Stabilization
Cellular Response To Hypoxia
Regulation Of Cellular Response To Hypoxia
Negative Regulation Of TORC1 Signaling
Amyloid Fibril Formation
Positive Regulation Of Endothelial Cell Proliferation
Cell Migration Involved In Sprouting Angiogenesis
Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Transcription By RNA Polymerase II
Protein Import Into Nucleus
Apoptotic Process
Inflammatory Response
Signal Transduction
Intracellular Receptor Signaling Pathway
Detection Of Lipopolysaccharide
Endothelial Cell Chemotaxis
Skeletal Muscle Cell Differentiation
Cellular Response To Vascular Endothelial Growth Factor Stimulus
Macrophage Activation
Positive Regulation Of Apoptotic Process
Cellular Response To Fibroblast Growth Factor Stimulus
Fat Cell Differentiation
Negative Regulation Of Cell Cycle
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Type B Pancreatic Cell Proliferation
Cellular Response To Corticotropin-releasing Hormone Stimulus
Non-canonical Inflammasome Complex Assembly
Pathways
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
SUMOylation of ubiquitinylation proteins
Neddylation
Replication of the SARS-CoV-1 genome
Replication of the SARS-CoV-2 genome
RHOBTB3 ATPase cycle
Antigen processing: Ubiquitination & Proteasome degradation
AKT phosphorylates targets in the nucleus
Nuclear Receptor transcription pathway
Constitutive Signaling by AKT1 E17K in Cancer
Drugs
Diseases
von Hippel-Lindau syndrome
Congenital polycythemia; Familial erythrocytosis (ECYT)
Renal cell carcinoma
GWAS
Bullous pemphigoid (
34011352
)
Hip circumference adjusted for BMI (
34021172
)
Interacting Genes
172 interacting genes:
ACTB
AHI1
AKT1
ANKEF1
ANKRD11
APP
ARHGEF7
AURKA
BEX2
BEX4
BRCA1
BRD4
CAPN7
CAPZB
CASR
CBR1
CBX1
CBX3
CCNC
CCT3
CCT5
CCT7
CD44
CDC34
CDK1
CDK5RAP3
CDKN2A
CERKL
CHEK2
CLU
COL4A2
COMMD1
CPNE5
CSNK2A1
CUL2
CUL5
DGKI
DIDO1
DNAJA3
DSTN
DVL2
E2F1
EEF1A1
EEF1B2
EGLN1
ELOB
ELOC
EPAS1
EPOR
ERI1
ETFA
FBXO28
FBXO34
FKBP8
FLNA
FLOT1
FN1
GHET1
GPANK1
GPS1
GTF3C2
GUK1
H1-2
H2BC13
H4C16
HDAC1
HDAC2
HDAC3
HIF1A
HIF1AN
HIF3A
HNRNPA2B1
HNRNPD
HSF2BP
HSPA5
HSPA8
IFT88
IKBKB
ITPKC
JADE1
KIF2C
KIF3A
KLF4
KLHL10
LANCL1
MAP1B
MAP1LC3B
MAP1S
MDFI
MRPS9
MSL2
MT-CO2
NCL
NISCH
NR4A1
NR4A2
NR4A3
NSUN5
NSUN7
OTUD6B
PAX2
PDCD5
PFKP
PHB2
PIAS4
PIWIL4
PKP2
PLD1
PLD2
POLR2G
PPP1R13L
PPP5C
PRDX1
PRKCI
PRKG1
PRMT1
PRMT8
PSMC1
PSMC3
RB1CC1
RBPMS
RBPMS2
RBX1
RERE
RHOBTB3
RNF139
RPL21
RPL5
RPS15A
RWDD3
SAP30
SARNP
SAT2
SELENOP
SETDB1
SKP2
SLC2A1
SLC3A2
SMC5
SNRNP200
SON
SP1
SPARC
SPATA22
SPZ1
STAMBP
SUV39H2
TBK1
TDRD7
TEX35
TPT1
TRIM28
TTC3
UBE2D1
UBE2D2
UBE2D3
UBE2I
USP20
USP33
USP9X
UXT
VAPB
VBP1
VRK1
WSB1
YY1AP1
ZBTB17
ZNF197
ZNF200
ZNF512B
ZNF668
ZNF827
86 interacting genes:
ABCA5
ABCB11
ABCC13
ABCC6
ABCG8
AKT1
ANKIB1
ARHGEF10L
ARHGEF5
ATM
ATXN1
BBS10
BCL2
BCL2A1
BCL2L10
CD2AP
CDKN2D
CHD1L
CHD3
CHEK2
CPT1A
CUTA
DIABLO
EP300
FAF1
FXYD3
GADD45GIP1
GK
GLOD4
GLUD1
HADHA
HES1
HIF1A
HNRNPA2B1
HSP90AB1
KAT2B
KRTAP10-1
KRTAP10-5
LONRF1
LSS
MAP3K1
MAPK1
MAPK8
MED1
MED31
NACAD
NCOA1
NCOA2
NCOA3
NCOR2
NDRG1
NFKB1
NR3C1
PGBD1
PML
POLA2
PPARG
PPBP
PPM1A
PRDX4
PRDX6
RBL1
ROBO2
RPL7
RPS6KA1
RPS6KA3
RPS6KA5
RPS6KA6
RTN4
RXRA
RXRG
SERPINA4
SERPING1
SOCS4
STAT3
SUGT1
TCF4
TP53
TRAF2
TRIM28
TUBB4A
VASP
VHL
YWHAZ
ZNF331
ZNF579
Entrez ID
7428
3164
HPRD ID
01905
00744
Ensembl ID
ENSG00000134086
ENSG00000123358
Uniprot IDs
A0A024R2F2
A0A0S2Z4K1
A0A8Q3WL21
P40337
F5GXF0
P22736
Q6ZMM6
PDB IDs
1LM8
1LQB
1VCB
3ZRC
3ZRF
3ZTC
3ZTD
3ZUN
4AJY
4AWJ
4B95
4B9K
4BKS
4BKT
4W9C
4W9D
4W9E
4W9F
4W9G
4W9H
4W9I
4W9J
4W9K
4W9L
4WQO
5LLI
5N4W
5NVV
5NVW
5NVX
5NVY
5NVZ
5NW0
5NW1
5NW2
5T35
6BVB
6FMI
6FMJ
6FMK
6GFX
6GFY
6GFZ
6GMN
6GMQ
6GMR
6GMX
6HAX
6HAY
6HR2
6I7Q
6I7R
6R6H
6R7F
6SIS
6ZHC
7CJB
7JTO
7JTP
7KHH
7PI4
7Q2J
7S4E
7Z6L
7Z76
7Z77
7ZNT
8BB2
8BB3
8BB4
8BB5
8BDI
8BDJ
8BDL
8BDM
8BDN
8BDO
8BDS
8BDT
8BDX
8BEB
8C13
8CQE
8CQK
8CQL
8EI3
8EWV
8FY0
8FY1
8FY2
8G1P
8G1Q
8P0F
8PC2
8QJR
8QJS
8QU8
8QVU
8QW6
8QW7
8R5H
8RWZ
8RX0
8VL9
8VLB
8WDK
8YMB
8ZV8
8ZVJ
9BJU
9BOL
9EQJ
9EQM
9IPW
2QW4
3V3E
3V3Q
4JGV
4KZI
4KZJ
4KZM
4RE8
4REE
4REF
4RZE
4RZF
4RZG
4WHF
4WHG
6KZ5
6LC1
8WUY
8Y7L
Enriched GO Terms of Interacting Partners
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Nucleus
Regulation Of Primary Metabolic Process
Nucleoplasm
Regulation Of Macromolecule Metabolic Process
Regulation Of Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of DNA-templated Transcription
Regulation Of Macromolecule Biosynthetic Process
Regulation Of RNA Biosynthetic Process
Regulation Of RNA Metabolic Process
Regulation Of Gene Expression
Regulation Of Protein Metabolic Process
Negative Regulation Of Macromolecule Metabolic Process
Cytoplasm
Post-translational Protein Modification
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Negative Regulation Of Metabolic Process
Regulation Of Post-translational Protein Modification
Cellular Response To Stress
Positive Regulation Of Protein Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Apoptotic Process
Positive Regulation Of Metabolic Process
Cytosol
Protein Modification Process
Protein Modification By Small Protein Conjugation
Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Signal Transduction
Regulation Of Programmed Cell Death
Macromolecule Metabolic Process
Protein Metabolic Process
Negative Regulation Of Signaling
Negative Regulation Of Cell Communication
Protein-containing Complex
Negative Regulation Of Intracellular Signal Transduction
Protein Binding
Positive Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of RNA Metabolic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of RNA Biosynthetic Process
Regulation Of Protein Stability
Chromatin Remodeling
Positive Regulation Of Biosynthetic Process
NF-kappaB Binding
Response To Stress
Negative Regulation Of Apoptotic Process
Intracellular Signal Transduction
Intracellular Signal Transduction
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Programmed Cell Death
Regulation Of Apoptotic Process
TOR Signaling
Positive Regulation Of RNA Metabolic Process
TORC1 Signaling
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Intracellular Receptor Signaling Pathway
Response To Lipid
Peroxisome Proliferator Activated Receptor Signaling Pathway
Nuclear Receptor-mediated Signaling Pathway
Nuclear Receptor Binding
Ubiquitin Protein Ligase Binding
Programmed Cell Death
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Cell Death
Positive Regulation Of Biosynthetic Process
Protein-containing Complex
Cellular Response To Stress
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Small Molecule Metabolic Process
Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Metabolic Process
Apoptotic Process
Negative Regulation Of Programmed Cell Death
Nucleoplasm
Intrinsic Apoptotic Signaling Pathway
Response To Nutrient Levels
Identical Protein Binding
MRNA Transcription
Positive Regulation Of Macromolecule Biosynthetic Process
Regulation Of RNA Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of RNA Biosynthetic Process
Negative Regulation Of Apoptotic Process
Regulation Of Protein Stability
Response To Decreased Oxygen Levels
Negative Regulation Of RNA Metabolic Process
Response To Hormone
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Retinoic Acid Receptor Signaling Pathway
Positive Regulation Of Developmental Process
Response To Oxygen Levels
MRNA Transcription By RNA Polymerase II
DNA Damage Response, Signal Transduction By P53 Class Mediator
Regulation Of Primary Metabolic Process
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