VHL and RPL5

Number of citations of the paper that reports this interaction (PMID 22234250)
1

Data Source:
BioGRID (pull down)

		VHL	RPL5
Gene Name		von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase	ribosomal protein L5
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Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Mitochondrion Endoplasmic Reticulum Cytosol Membrane Intermediate Filament Cytoskeleton	Nucleus Nucleolus Cytoplasm Cytosol Focal Adhesion Membrane Cytosolic Large Ribosomal Subunit Ribonucleoprotein Complex Extracellular Vesicular Exosome
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Transcription Factor Binding Enzyme Binding Ubiquitin Protein Ligase Activity	RNA Binding Structural Constituent Of Ribosome Protein Binding 5S RRNA Binding Poly(A) RNA Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Cell Morphogenesis Regulation Of Transcription, DNA-templated Proteolysis Negative Regulation Of Cell Proliferation Protein Ubiquitination Negative Regulation Of Apoptotic Process Positive Regulation Of Cell Differentiation Positive Regulation Of Transcription, DNA-templated Protein Stabilization Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Cellular Response To Hypoxia	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay RRNA Processing Translation Translational Initiation Translational Elongation Translational Termination SRP-dependent Cotranslational Protein Targeting To Membrane Gene Expression Viral Process Viral Life Cycle Viral Transcription Ribosomal Large Subunit Biogenesis Cellular Protein Metabolic Process
Pathways		Cellular response to hypoxia Antigen processing: Ubiquitination & Proteasome degradation Regulation of Hypoxia-inducible Factor (HIF) by oxygen Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Class I MHC mediated antigen processing & presentation Adaptive Immune System	Nonsense-Mediated Decay (NMD) Translation SRP-dependent cotranslational protein targeting to membrane Eukaryotic Translation Termination Peptide chain elongation Influenza Infection Viral mRNA Translation L13a-mediated translational silencing of Ceruloplasmin expression Influenza Life Cycle Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Influenza Viral RNA Transcription and Replication GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Initiation Formation of a pool of free 40S subunits Eukaryotic Translation Elongation Cap-dependent Translation Initiation Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS			Height ( 20881960) Multiple sclerosis ( 19525955 17660530)
Protein-Protein Interactions		85 interactors: ACTB APP AR AURKA CAPN7 CAPZB CBR1 CBX1 CBX3 CCT3 CD44 CDC34 CHEK2 CLU CSNK2A1 CUL2 CUL5 DGKI DNAJA3 DVL2 E2F1 EEF1B2 EPAS1 FKBP8 FLNA FN1 HDAC1 HDAC2 HDAC3 HIF1A HIF1AN HIF3A HIST1H1C HIST1H2BL HIST4H4 HNRNPA2B1 HNRNPD HSPA5 HSPA8 JADE1 KIF2C KIF3A KLF4 LANCL1 MDFI NCL NR4A1 NR4A2 NR4A3 PDCD5 PLD1 POLR2G PRDX1 PRKCD PRKCI PRMT1 PRMT8 PSMC3 RB1CC1 RBPMS RBPMS2 RBX1 RNF139 RPL21 RPL5 RPS15A SARNP SAT2 SKP2 SLC2A1 SLC3A2 SON SP1 TCEB1 TCEB2 TRIM28 UBE2D1 USP20 USP33 UXT VAPB VBP1 YY1AP1 ZNF197 ZNF512B	21 interactors: CSNK2A1 CSNK2B DCC EIF5A HARS IPO13 IPO5 IPO7 KPNB1 MAP3K14 MDM2 NVL PDCD4 PPM1D SPP1 SURF2 TNIP1 TNPO1 TSC22D1 UPF2 VHL
Entrez ID		7428	6125
HPRD ID		01905	04699
Ensembl ID			ENSG00000122406
Uniprot IDs		P40337	A2RUM7 B3KTM6 P46777
PDB IDs		1LM8 1LQB 1VCB 3ZRC 3ZRF 3ZTC 3ZTD 3ZUN 4AJY 4AWJ 4B95 4B9K	3J3B
Enriched GO Terms of Interacting Partners?		Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Response To Stress Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Gene Expression Cellular Metabolic Process RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of Transcription, DNA-templated RNA Metabolic Process Transcription, DNA-templated Regulation Of Cellular Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Metabolic Process Cellular Response To Stress Positive Regulation Of Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Nucleobase-containing Compound Metabolic Process Cellular Response To Oxygen Levels Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Cell Death Nitrogen Compound Metabolic Process Positive Regulation Of Protein Metabolic Process Blood Coagulation Positive Regulation Of Cellular Protein Metabolic Process Hemostasis Heterocycle Metabolic Process Positive Regulation Of Gene Expression Cellular Aromatic Compound Metabolic Process Regulation Of Apoptotic Process Regulation Of Protein Metabolic Process Transcription From RNA Polymerase II Promoter Regulation Of Body Fluid Levels Biosynthetic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Cell Death Regulation Of Transcription From RNA Polymerase II Promoter Wound Healing Regulation Of Signal Transduction Response To Stimulus	Nucleocytoplasmic Transport Nuclear Transport Protein Localization To Nucleus Protein Import Into Nucleus Nuclear Import Protein Import Cytoplasmic Transport Protein Localization To Organelle Establishment Of Protein Localization To Organelle Negative Regulation Of Collateral Sprouting Ribosomal Protein Import Into Nucleus Protein Targeting NLS-bearing Protein Import Into Nucleus Intracellular Protein Transport Cellular Protein Localization Viral Process Apoptotic Process Establishment Of Protein Localization Regulation Of Cell Proliferation Programmed Cell Death Intracellular Transport Cell Death Death Protein Import Into Nucleus, Translocation Cellular Localization Response To External Stimulus Protein Localization Protein Transport Establishment Of Localization In Cell Modulation By Symbiont Of Host I-kappaB Kinase/NF-kappaB Cascade Cellular Response To UV-C Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Cellular Response To Vitamin B1 Negative Regulation Of Axonogenesis Chemotaxis MRNA Export From Nucleus Regulation Of MAPK Cascade Histidyl-tRNA Aminoacylation Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury RNA Export From Nucleus Regulation Of Catalytic Activity Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Negative Regulation Of Developmental Growth Spinal Cord Ventral Commissure Morphogenesis Netrin-activated Signaling Pathway Positive Regulation Of Protein Metabolic Process Regulation Of Cell Growth Mitotic Cell Cycle Cellular Response To Hypoxia
Tagcloud ?		ankyrin attenuates bc belonging binds box collection degenerate elongation elongin hippel inhibiting initially interacting jak lindau motif multifunctional multiprotein participates pol repeat skp1 socs spry stat suppressor von wd	biogenesis biosynthesis dehydrogenase deoxy disrupts dually genotoxic gtp guanine imp impdh2 inauzhin inosine inz mdm2 monophosphate notion nucleostemin pools ribonucleotide ribosomal rpl11 rps rrna rs sirt1 stressor suppresses surprisingly
Tagcloud (Difference) ?		ankyrin attenuates bc belonging binds box collection degenerate elongation elongin hippel inhibiting initially interacting jak lindau motif multifunctional multiprotein participates pol repeat skp1 socs spry stat suppressor von wd	biogenesis biosynthesis dehydrogenase deoxy disrupts dually genotoxic gtp guanine imp impdh2 inauzhin inosine inz mdm2 monophosphate notion nucleostemin pools ribonucleotide ribosomal rpl11 rps rrna rs sirt1 stressor suppresses surprisingly
Tagcloud (Intersection) ?