CD44 and CDKN2B

Number of citations: 55 (PubMedID 28205554)
Data Source: BioGRID (fluorescent resonance energy transfer)

		CD44	CDKN2B
Name		CD44 molecule (IN blood group)	cyclin dependent kinase inhibitor 2B
Structure			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Golgi Apparatus Cytosol Plasma Membrane Microvillus Focal Adhesion Cell Surface Membrane Basolateral Plasma Membrane Apical Plasma Membrane Secretory Granule Membrane Lamellipodium Membrane Protein-containing Complex Macrophage Migration Inhibitory Factor Receptor Complex Cell Projection Extracellular Exosome	Nucleus Cytoplasm Cytosol
	Molecular Function	Transmembrane Signaling Receptor Activity Cytokine Receptor Activity Protein Binding Collagen Binding Hyaluronic Acid Binding	Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Protein Binding Protein Kinase Binding
	Biological Process	Inflammatory Response Cell Adhesion Cell-matrix Adhesion Anatomical Structure Morphogenesis Cell Migration Cytokine-mediated Signaling Pathway Hyaluronan Catabolic Process Positive Regulation Of Heterotypic Cell-cell Adhesion T Cell Activation Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Wound Healing, Spreading Of Cells Cellular Response To Fibroblast Growth Factor Stimulus System Development Cartilage Development Positive Regulation Of ERK1 And ERK2 Cascade Monocyte Aggregation Cell-cell Adhesion Positive Regulation Of Monocyte Aggregation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Regulation Of Lamellipodium Morphogenesis	Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Cell Population Proliferation Megakaryocyte Differentiation Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Nutrient Spleen Development Negative Regulation Of Epithelial Cell Proliferation Regulation Of G0 To G1 Transition Cellular Response To Cell-matrix Adhesion Cellular Senescence Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		Degradation of the extracellular matrix Cell surface interactions at the vascular wall Hyaluronan metabolism Integrin cell surface interactions Hyaluronan degradation Neutrophil degranulation Interferon gamma signaling Developmental Lineage of Mammary Gland Luminal Epithelial Cells Developmental Lineage of Mammary Gland Myoepithelial Cells Developmental Lineage of Mammary Stem Cells	SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) Oncogene Induced Senescence Cyclin D associated events in G1
Drugs		Bivatuzumab Hyaluronic acid	None
Diseases		Gastric cancer	Type II diabetes mellitus Osteosarcoma Malignant pleural mesothelioma
GWAS		Bone mineral density (hip) ( 30172743 ) Glycemic traits (pleiotropy) ( 31021400 ) Intake of sweets ( 31005972 ) Response to Vitamin E supplementation ( 22437554 ) Systemic lupus erythematosus ( 23273568 26502338 27399966 28714469 ) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010 ) Total body bone mineral density ( 29304378 ) Uterine fibroids ( 31649266 ) Vitiligo ( 22561518 27723757 )	Ankle-brachial index ( 22199011 ) Basal cell carcinoma ( 27539887 25855136 24403052 ) Breast cancer ( 29059683 23535729 20453838 ) Cancer ( 27197191 ) Cancer (pleiotropy) ( 27197191 ) Carotid plaque burden ( 28282560 ) Cataracts ( 34127677 ) Chronic lymphocytic leukemia ( 23770605 ) Coronary artery calcification ( 23561647 22144573 ) Coronary artery disease ( 26708285 21239051 29212778 29263402 ) Coronary heart disease ( 21378990 29615537 21971053 17554300 ) Coronary heart disease (SNP X SNP interaction) ( 21626137 ) Coronary heart disease x type 2 diabetes interaction ( 32541925 ) Cutaneous malignant melanoma ( 32341527 ) Endometrial cancer ( 30093612 ) Endometrial cancer (endometrioid histology) ( 30093612 ) Endometriosis ( 23104006 ) Esophageal squamous cell carcinoma ( 25129146 ) Facial pigmentation measurement (polar light) ( 32835660 ) Facial pigmentation measurement (UV light) ( 32835660 ) Fasting blood glucose ( 33842983 22581228 25631608 ) Fasting blood glucose (BMI interaction) ( 22581228 ) Fasting plasma glucose ( 25187374 ) Glaucoma ( 22792221 ) Glaucoma (primary open-angle) ( 22419738 ) Glioblastoma ( 28346443 ) Glioblastoma (age-stratified) ( 30152087 ) Glioma ( 28346443 21531791 19578367 ) Haemorrhoidal disease ( 33888516 ) Inflammatory bowel disease ( 27569725 ) Intracranial aneurysm ( 18997786 20364137 ) Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy) ( 27418160 ) Metabolically unhealthy in normal weight ( 33500527 ) Metabolite levels ( 23823483 ) Myocardial infarction ( 17478679 ) Myocardial infarction (early onset) ( 19198609 ) Nasopharyngeal carcinoma ( 26545403 20512145 ) Non-glioblastoma glioma ( 28346443 ) Non-melanoma skin cancer ( 29739929 ) Parental longevity (both parents in top 10%) ( 29227965 ) Parental longevity (father's age at death) ( 29227965 ) Psychosis proneness (hypomanic personality scale and perceptual aberration scale) ( 28525603 ) Psychosis proneness (hypomanic personality scale and revised physical anhedonia scale) ( 28525603 ) Psychosis proneness (hypomanic personality scale and revised social anhedonia scale) ( 28525603 ) Psychosis proneness (hypomanic personality scale) ( 28525603 ) Pulse pressure ( 27841878 ) Spleen volume ( 34128465 ) Type 2 diabetes ( 30718926 17463246 17463248 17463249 18372903 19056611 19401414 20581827 21573907 27189021 30297969 22293688 22961080 23945395 24509480 26818947 29358691 26961502 ) Vertical cup-disc ratio ( 20548946 )
Novel Interactors		9 novel interactors: BDNF CAT CSTF3 DPT LMO2 MAP3K13 NONO RIMS2 SRD5A1	1 novel interactors: ELAVL2
Interacting Genes		61 interacting genes: ABCB1 ABCB5 AKT1 ANK1 ANXA1 ARHGEF1 ARHGEF12 ARNT CCND2 CD4 CD74 CDK4 CDK6 CDKN2A CDKN2B COL14A1 COL1A1 COL1A2 CSK DMP1 EGFR EPB41 EPHA2 ERBB4 EZR FGF2 FGFR4 FN1 FYN GARS1 GLIS2 GRM1 HBEGF HMMR IGFBP3 KDELR2 LATS2 LCK MADCAM1 MAP2K3 MAP2K5 MDM4 MET MMP1 MMP7 MMP9 NF2 PDGFRA PKN1 RAF1 SELE SPP1 SRC SRGN STK11 TGFBR1 TGFBR2 TIAM1 VAV2 VCAN VHL	63 interacting genes: AKT1 APP ARAF ARNT ARPC3 ATP6V1H BECN1 CBLC CCDC33 CCDC90B CCNC CCND2 CCNE1 CD44 CDK17 CDK4 CDK6 CDK8 CDKN2C CEP126 CNKSR3 ELP1 EPHA2 ERBB2 FGFR4 FZR1 GLIS2 GRM1 HGF HIF1A IGF1R INCA1 ISL1 KAT2A KDELR2 LATS2 MAGEA11 MAP2K3 MAP2K5 MAP2K6 MDM4 MET MYC NF2 NIF3L1 PDGFRA PICK1 PYCR3 RAF1 RASSF1 RTL8C RUSC1 SPG21 STK11 TEAD2 TERT TGFB1I1 TNFRSF1A TP53 TRAF1 TSC1 TTYH2 ZBTB17
Entrez ID		960	1030
HPRD ID		00115	02696
Ensembl ID		ENSG00000026508	ENSG00000147883
Uniprot IDs		P16070	K7PPU3 P42772
PDB IDs		1POZ 1UUH 2I83 4PZ3 4PZ4 6TXS	Not available
GO Terms Enriched among Interactors		Enzyme-linked Receptor Protein Signaling Pathway Protein Kinase Activity Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cell Motility Regulation Of Cell Communication Regulation Of Signaling Kinase Activity Regulation Of Locomotion Regulation Of Cell Population Proliferation Regulation Of Developmental Process Regulation Of Cell Migration Positive Regulation Of Cell Migration Regulation Of Multicellular Organismal Process Positive Regulation Of Cell Motility Positive Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Protein Tyrosine Kinase Activity Positive Regulation Of Locomotion Positive Regulation Of Cell Communication Positive Regulation Of Signaling Cell Differentiation Intracellular Signal Transduction Protein Phosphorylation Animal Organ Development Developmental Process Regulation Of Growth Cellular Developmental Process Response To Growth Factor Phosphorylation Regulation Of Protein Phosphorylation Positive Regulation Of Intracellular Signal Transduction Regulation Of Protein Modification Process ATP Binding Cellular Response To Growth Factor Stimulus Regulation Of MAPK Cascade Regulation Of Multicellular Organismal Development Regulation Of Cell Differentiation Regulation Of Phosphorylation Positive Regulation Of Developmental Process Cell Migration Positive Regulation Of Cell Population Proliferation Positive Regulation Of Growth Regulation Of Cell Growth Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Phosphorus Metabolic Process Positive Regulation Of Cell Differentiation Regulation Of Programmed Cell Death	Protein Kinase Activity Regulation Of Cell Cycle Response To Growth Factor Kinase Activity Regulation Of Cell Population Proliferation Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Signal Transduction Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Negative Regulation Of Signaling Regulation Of Apoptotic Signaling Pathway Signal Transduction Negative Regulation Of Cell Communication Regulation Of MAPK Cascade Protein Tyrosine Kinase Activity Negative Regulation Of Programmed Cell Death Cellular Response To Decreased Oxygen Levels Negative Regulation Of Signal Transduction Protein Serine Kinase Activity Cellular Response To Growth Factor Stimulus Negative Regulation Of Cell Population Proliferation Regulation Of Metabolic Process Cellular Response To Oxygen Levels Intracellular Signal Transduction Negative Regulation Of Apoptotic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Cyclin-dependent Protein Kinase Holoenzyme Complex Cell Surface Receptor Signaling Pathway Animal Organ Development Protein Serine/threonine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Cell Population Proliferation Protein Phosphorylation Positive Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Intracellular Signal Transduction Cellular Response To Stress Regulation Of DNA-templated Transcription Regulation Of Phosphorus Metabolic Process Positive Regulation Of Cell Population Proliferation Regulation Of RNA Biosynthetic Process Phosphorylation