CD44 and DPT

Data Source: HiPPIP (Novel)

		CD44	DPT
Name		CD44 molecule (IN blood group)	dermatopontin
Structure			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Golgi Apparatus Cytosol Plasma Membrane Microvillus Focal Adhesion Cell Surface Membrane Basolateral Plasma Membrane Apical Plasma Membrane Secretory Granule Membrane Lamellipodium Membrane Protein-containing Complex Macrophage Migration Inhibitory Factor Receptor Complex Cell Projection Extracellular Exosome	Extracellular Region Extracellular Space Extracellular Matrix
	Molecular Function	Transmembrane Signaling Receptor Activity Cytokine Receptor Activity Protein Binding Collagen Binding Hyaluronic Acid Binding	Extracellular Matrix Structural Constituent Protein Binding
	Biological Process	Inflammatory Response Cell Adhesion Cell-matrix Adhesion Anatomical Structure Morphogenesis Cell Migration Cytokine-mediated Signaling Pathway Hyaluronan Catabolic Process Positive Regulation Of Heterotypic Cell-cell Adhesion T Cell Activation Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Wound Healing, Spreading Of Cells Cellular Response To Fibroblast Growth Factor Stimulus System Development Cartilage Development Positive Regulation Of ERK1 And ERK2 Cascade Monocyte Aggregation Cell-cell Adhesion Positive Regulation Of Monocyte Aggregation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Regulation Of Lamellipodium Morphogenesis	Cell Adhesion Negative Regulation Of Cell Population Proliferation Collagen Fibril Organization
Pathways		Degradation of the extracellular matrix Cell surface interactions at the vascular wall Hyaluronan metabolism Integrin cell surface interactions Hyaluronan degradation Neutrophil degranulation Interferon gamma signaling Developmental Lineage of Mammary Gland Luminal Epithelial Cells Developmental Lineage of Mammary Gland Myoepithelial Cells Developmental Lineage of Mammary Stem Cells	None
Drugs		Bivatuzumab Hyaluronic acid	None
Diseases		Gastric cancer	None
GWAS		Bone mineral density (hip) ( 30172743 ) Glycemic traits (pleiotropy) ( 31021400 ) Intake of sweets ( 31005972 ) Response to Vitamin E supplementation ( 22437554 ) Systemic lupus erythematosus ( 23273568 26502338 27399966 28714469 ) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010 ) Total body bone mineral density ( 29304378 ) Uterine fibroids ( 31649266 ) Vitiligo ( 22561518 27723757 )	Blood protein levels ( 30072576 ) Diisocyanate-induced asthma ( 25918132 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Electrocardiographic traits (multivariate) ( 32602732 ) Morbidity-free survival ( 17903295 ) PR interval ( 32439900 ) Rosacea symptom severity ( 29771307 )
Interacting Genes		61 interacting genes: ABCB1 ABCB5 AKT1 ANK1 ANXA1 ARHGEF1 ARHGEF12 ARNT CCND2 CD4 CD74 CDK4 CDK6 CDKN2A CDKN2B COL14A1 COL1A1 COL1A2 CSK DMP1 EGFR EPB41 EPHA2 ERBB4 EZR FGF2 FGFR4 FN1 FYN GARS1 GLIS2 GRM1 HBEGF HMMR IGFBP3 KDELR2 LATS2 LCK MADCAM1 MAP2K3 MAP2K5 MDM4 MET MMP1 MMP7 MMP9 NF2 PDGFRA PKN1 RAF1 SELE SPP1 SRC SRGN STK11 TGFBR1 TGFBR2 TIAM1 VAV2 VCAN VHL	4 interacting genes: BAG6 DCN LOX TGFB1
Entrez ID		960	1805
HPRD ID		00115	00510
Ensembl ID		ENSG00000026508	ENSG00000143196
Uniprot IDs		P16070	Q07507
PDB IDs		1POZ 1UUH 2I83 4PZ3 4PZ4 6TXS	Not available
GO Terms Enriched among Interactors		Enzyme-linked Receptor Protein Signaling Pathway Protein Kinase Activity Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cell Motility Regulation Of Cell Communication Regulation Of Signaling Kinase Activity Regulation Of Locomotion Regulation Of Cell Population Proliferation Regulation Of Developmental Process Regulation Of Cell Migration Positive Regulation Of Cell Migration Regulation Of Multicellular Organismal Process Positive Regulation Of Cell Motility Positive Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Protein Tyrosine Kinase Activity Positive Regulation Of Locomotion Positive Regulation Of Cell Communication Positive Regulation Of Signaling Cell Differentiation Intracellular Signal Transduction Protein Phosphorylation Animal Organ Development Developmental Process Regulation Of Growth Cellular Developmental Process Response To Growth Factor Phosphorylation Regulation Of Protein Phosphorylation Positive Regulation Of Intracellular Signal Transduction Regulation Of Protein Modification Process ATP Binding Cellular Response To Growth Factor Stimulus Regulation Of MAPK Cascade Regulation Of Multicellular Organismal Development Regulation Of Cell Differentiation Regulation Of Phosphorylation Positive Regulation Of Developmental Process Cell Migration Positive Regulation Of Cell Population Proliferation Positive Regulation Of Growth Regulation Of Cell Growth Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Phosphorus Metabolic Process Positive Regulation Of Cell Differentiation Regulation Of Programmed Cell Death	Glycosaminoglycan Catabolic Process Hyaluronan Catabolic Process Hyaluronan Metabolic Process Muscle Cell Cellular Homeostasis Extracellular Matrix Assembly T Cell Activation Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Striated Muscle Tissue Development Regulation Of Muscle Organ Development Glycosaminoglycan Metabolic Process Extracellular Region Collagen Binding Microvillus Regulation Of Developmental Process Extracellular Matrix Negative Regulation Of Endothelial Cell Migration Descending Aorta Development Ascending Aorta Development Connective Tissue Development Branch Elongation Involved In Mammary Gland Duct Branching Positive Regulation Of Microglia Differentiation Cellular Response To Acetaldehyde Lymphocyte Activation Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Leukocyte Activation Positive Regulation Of Monocyte Aggregation Anatomical Structure Morphogenesis Macrophage Migration Inhibitory Factor Receptor Complex Animal Organ Development Golgi Lumen Regulation Of Multicellular Organismal Development Lung Development Positive Regulation Of Primary MiRNA Processing Embryonic Liver Development Endoplasmic Reticulum Stress-induced Pre-emptive Quality Control Cell Activation Monocyte Aggregation Peptidyl-lysine Oxidation Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Frontal Suture Morphogenesis BAT3 Complex Negative Regulation Of Hyaluronan Biosynthetic Process Positive Regulation Of Exit From Mitosis Negative Regulation Of Skeletal Muscle Tissue Development Type III Transforming Growth Factor Beta Receptor Binding Langerhans Cell Differentiation Maintenance Of Unfolded Protein Carbohydrate Derivative Catabolic Process Positive Regulation Of ERK1 And ERK2 Cascade