CD44 and GRM1

Number of citations of the paper that reports this interaction (PubMedID 28205554)
55

Data Source:
BioGRID (fluorescent resonance energy transfer)

		CD44	GRM1
Description		CD44 molecule (IN blood group)	glutamate metabotropic receptor 1
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GO Annotations	Cellular Component	Extracellular Region Golgi Apparatus Cytosol Plasma Membrane Microvillus Focal Adhesion Cell Surface Membrane Basolateral Plasma Membrane Apical Plasma Membrane Secretory Granule Membrane Lamellipodium Membrane Protein-containing Complex Macrophage Migration Inhibitory Factor Receptor Complex Cell Projection Extracellular Exosome	Nucleus Plasma Membrane Postsynaptic Density Membrane Dendrite G Protein-coupled Receptor Dimeric Complex G Protein-coupled Receptor Homodimeric Complex Cell Projection Neuron Projection Dendriole Synapse Postsynaptic Membrane Schaffer Collateral - CA1 Synapse Postsynaptic Density Membrane Glutamatergic Synapse
	Molecular Function	Transmembrane Signaling Receptor Activity Cytokine Receptor Activity Protein Binding Collagen Binding Hyaluronic Acid Binding	Adenylate Cyclase Inhibiting G Protein-coupled Glutamate Receptor Activity G Protein-coupled Receptor Activity Protein Binding Glutamate Receptor Activity G Protein-coupled Neurotransmitter Receptor Activity Involved In Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration G Protein-coupled Receptor Activity Involved In Regulation Of Postsynaptic Membrane Potential Neurotransmitter Receptor Activity Involved In Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration
	Biological Process	Inflammatory Response Cell Adhesion Cell-matrix Adhesion Anatomical Structure Morphogenesis Cell Migration Cytokine-mediated Signaling Pathway Hyaluronan Catabolic Process Positive Regulation Of Heterotypic Cell-cell Adhesion T Cell Activation Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Wound Healing, Spreading Of Cells Cellular Response To Fibroblast Growth Factor Stimulus System Development Cartilage Development Positive Regulation Of ERK1 And ERK2 Cascade Monocyte Aggregation Cell-cell Adhesion Positive Regulation Of Monocyte Aggregation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Regulation Of Lamellipodium Morphogenesis	Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Glutamate Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Glutamate Receptor Signaling Pathway G Protein-coupled Glutamate Receptor Signaling Pathway Chemical Synaptic Transmission Locomotory Behavior Sensory Perception Of Pain Regulation Of Membrane Potential Positive Regulation Of MAPK Cascade Regulation Of Sensory Perception Of Pain Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Postsynaptic Membrane Potential Cellular Response To Electrical Stimulus L-glutamate Import Across Plasma Membrane Synaptic Signaling Via Neuropeptide Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration
Pathways		Degradation of the extracellular matrix Cell surface interactions at the vascular wall Hyaluronan metabolism Integrin cell surface interactions Hyaluronan degradation Neutrophil degranulation Interferon gamma signaling Developmental Lineage of Mammary Gland Luminal Epithelial Cells Developmental Lineage of Mammary Gland Myoepithelial Cells Developmental Lineage of Mammary Stem Cells	G alpha (q) signalling events Class C/3 (Metabotropic glutamate/pheromone receptors) Neurexins and neuroligins Neurexins and neuroligins Sensory perception of sweet, bitter, and umami (glutamate) taste
Drugs		Bivatuzumab Hyaluronic acid	Glutamic acid (S)-alpha-methyl-4-carboxyphenylglycine
Diseases		Gastric cancer
GWAS		Bone mineral density (hip) ( 30172743) Glycemic traits (pleiotropy) ( 31021400) Intake of sweets ( 31005972) Response to Vitamin E supplementation ( 22437554) Systemic lupus erythematosus ( 23273568 26502338 27399966 28714469) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010) Total body bone mineral density ( 29304378) Uterine fibroids ( 31649266) Vitiligo ( 22561518 27723757)	Cerebral amyloid deposition (PET imaging) ( 26252872) Suicide ( 31476763) Waist circumference ( 29212154)
Interacting Genes		61 interacting genes: ABCB1 ABCB5 AKT1 ANK1 ANXA1 ARHGEF1 ARHGEF12 ARNT CCND2 CD4 CD74 CDK4 CDK6 CDKN2A CDKN2B COL14A1 COL1A1 COL1A2 CSK DMP1 EGFR EPB41 EPHA2 ERBB4 EZR FGF2 FGFR4 FN1 FYN GARS1 GLIS2 GRM1 HBEGF HMMR IGFBP3 KDELR2 LATS2 LCK MADCAM1 MAP2K3 MAP2K5 MDM4 MET MMP1 MMP7 MMP9 NF2 PDGFRA PKN1 RAF1 SELE SPP1 SRC SRGN STK11 TGFBR1 TGFBR2 TIAM1 VAV2 VCAN VHL	41 interacting genes: ADORA1 BECN1 CABIN1 CASR CCND2 CCNE1 CD44 CDK4 CDK6 CDKN2B CDKN2C EFNB2 EPB41L2 EPHA2 ERBB2 FGFR4 GAPDH GPRASP1 GRK2 HOMER1 HOMER2 IGF1R ITPR1 KAT2A KDELR2 LATS2 MAP2K5 MYC NF2 OPRM1 OPTN PDGFRA PRKCA RAF1 RASSF1 STK11 TAMALIN TERT TTYH2 TUBB USP7
Entrez ID		960	2911
HPRD ID		00115	05129
Ensembl ID		ENSG00000026508	ENSG00000152822
Uniprot IDs		P16070	Q13255 Q59HC2
PDB IDs		1POZ 1UUH 2I83 4PZ3 4PZ4 6TXS	3KS9 4OR2 7DGD 7DGE
Enriched GO Terms of Interacting Partners?		Enzyme-linked Receptor Protein Signaling Pathway Protein Kinase Activity Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cell Motility Regulation Of Cell Communication Regulation Of Signaling Kinase Activity Regulation Of Locomotion Regulation Of Cell Population Proliferation Regulation Of Developmental Process Regulation Of Cell Migration Positive Regulation Of Cell Migration Regulation Of Multicellular Organismal Process Positive Regulation Of Cell Motility Positive Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Protein Tyrosine Kinase Activity Positive Regulation Of Locomotion Positive Regulation Of Cell Communication Positive Regulation Of Signaling Cell Differentiation Intracellular Signal Transduction Protein Phosphorylation Animal Organ Development Developmental Process Regulation Of Growth Cellular Developmental Process Response To Growth Factor Phosphorylation Regulation Of Protein Phosphorylation Positive Regulation Of Intracellular Signal Transduction Regulation Of Protein Modification Process ATP Binding Cellular Response To Growth Factor Stimulus Regulation Of MAPK Cascade Regulation Of Multicellular Organismal Development Regulation Of Cell Differentiation Regulation Of Phosphorylation Positive Regulation Of Developmental Process Cell Migration Positive Regulation Of Cell Population Proliferation Positive Regulation Of Growth Regulation Of Cell Growth Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Phosphorus Metabolic Process Positive Regulation Of Cell Differentiation Regulation Of Programmed Cell Death	Regulation Of Cell Population Proliferation Regulation Of Signal Transduction Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Regulation Of Intracellular Signal Transduction Kinase Activity Protein Kinase Activity Regulation Of MAPK Cascade Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Cellular Component Organization Positive Regulation Of Signal Transduction Regulation Of Cell Cycle Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Communication Negative Regulation Of Signaling Cell Surface Receptor Signaling Pathway G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Negative Regulation Of Cell Population Proliferation Positive Regulation Of MAPK Cascade Protein Phosphorylation Regulation Of Protein Localization Transmembrane Receptor Protein Tyrosine Kinase Activity Positive Regulation Of Intracellular Signal Transduction Regulation Of Epithelial Cell Proliferation Phosphorylation Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Signal Transduction Intracellular Signaling Cassette Protein Tyrosine Kinase Activity Regulation Of Multicellular Organismal Process Response To Growth Factor Regulation Of Cell Cycle Process Transferase Activity Mitotic Cell Cycle Phase Transition Intracellular Signal Transduction ATP Binding Cell Cycle Phase Transition Regulation Of Apoptotic Process Cyclin-dependent Protein Kinase Holoenzyme Complex Negative Regulation Of Apoptotic Process Protein Serine/threonine Kinase Activity Regulation Of Programmed Cell Death Regulation Of Cell Cycle G1/S Phase Transition Nucleotide Binding Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Programmed Cell Death Peptidyl-tyrosine Phosphorylation
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