CD44 and MAP3K13

Data Source: HiPPIP (Novel)

		CD44	MAP3K13
Name		CD44 molecule (IN blood group)	mitogen-activated protein kinase kinase kinase 13
Structure			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Golgi Apparatus Cytosol Plasma Membrane Microvillus Focal Adhesion Cell Surface Membrane Basolateral Plasma Membrane Apical Plasma Membrane Secretory Granule Membrane Lamellipodium Membrane Protein-containing Complex Macrophage Migration Inhibitory Factor Receptor Complex Cell Projection Extracellular Exosome	Cytoplasm Membrane
	Molecular Function	Transmembrane Signaling Receptor Activity Cytokine Receptor Activity Protein Binding Collagen Binding Hyaluronic Acid Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Enzyme Binding Protein Kinase Binding Identical Protein Binding Protein Homodimerization Activity Protein Serine/threonine Kinase Activator Activity Metal Ion Binding IkappaB Kinase Complex Binding Protein Serine Kinase Activity
	Biological Process	Inflammatory Response Cell Adhesion Cell-matrix Adhesion Anatomical Structure Morphogenesis Cell Migration Cytokine-mediated Signaling Pathway Hyaluronan Catabolic Process Positive Regulation Of Heterotypic Cell-cell Adhesion T Cell Activation Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Wound Healing, Spreading Of Cells Cellular Response To Fibroblast Growth Factor Stimulus System Development Cartilage Development Positive Regulation Of ERK1 And ERK2 Cascade Monocyte Aggregation Cell-cell Adhesion Positive Regulation Of Monocyte Aggregation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Regulation Of Lamellipodium Morphogenesis	Protein Phosphorylation JNK Cascade Positive Regulation Of Neuron Maturation Intracellular Signal Transduction Positive Regulation Of Axon Extension Protein Autophosphorylation Positive Regulation Of NF-kappaB Transcription Factor Activity Stress-activated MAPK Cascade Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Neuron Projection Arborization Positive Regulation Of Branching Morphogenesis Of A Nerve
Pathways		Degradation of the extracellular matrix Cell surface interactions at the vascular wall Hyaluronan metabolism Integrin cell surface interactions Hyaluronan degradation Neutrophil degranulation Interferon gamma signaling Developmental Lineage of Mammary Gland Luminal Epithelial Cells Developmental Lineage of Mammary Gland Myoepithelial Cells Developmental Lineage of Mammary Stem Cells	None
Drugs		Bivatuzumab Hyaluronic acid	Fostamatinib
Diseases		Gastric cancer	None
GWAS		Bone mineral density (hip) ( 30172743 ) Glycemic traits (pleiotropy) ( 31021400 ) Intake of sweets ( 31005972 ) Response to Vitamin E supplementation ( 22437554 ) Systemic lupus erythematosus ( 23273568 26502338 27399966 28714469 ) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010 ) Total body bone mineral density ( 29304378 ) Uterine fibroids ( 31649266 ) Vitiligo ( 22561518 27723757 )	Airflow obstruction ( 22837378 ) Arterial stiffness index ( 31235810 ) Major depressive disorder ( 27519822 ) Neonatal white matter microstructure ( 33009551 )
Novel Interactors		9 novel interactors: BDNF CAT CSTF3 DPT LMO2 MAP3K13 NONO RIMS2 SRD5A1	1 novel interactors: CD44
Interacting Genes		61 interacting genes: ABCB1 ABCB5 AKT1 ANK1 ANXA1 ARHGEF1 ARHGEF12 ARNT CCND2 CD4 CD74 CDK4 CDK6 CDKN2A CDKN2B COL14A1 COL1A1 COL1A2 CSK DMP1 EGFR EPB41 EPHA2 ERBB4 EZR FGF2 FGFR4 FN1 FYN GARS1 GLIS2 GRM1 HBEGF HMMR IGFBP3 KDELR2 LATS2 LCK MADCAM1 MAP2K3 MAP2K5 MDM4 MET MMP1 MMP7 MMP9 NF2 PDGFRA PKN1 RAF1 SELE SPP1 SRC SRGN STK11 TGFBR1 TGFBR2 TIAM1 VAV2 VCAN VHL	8 interacting genes: GLO1 HLA-DRB3 IKBKB MAP2K7 MAPK8IP1 PRDX3 STAT3 TRIM25
Entrez ID		960	9175
HPRD ID		00115	05372
Ensembl ID		ENSG00000026508	ENSG00000073803
Uniprot IDs		P16070	O43283
PDB IDs		1POZ 1UUH 2I83 4PZ3 4PZ4 6TXS	Not available
GO Terms Enriched among Interactors		Enzyme-linked Receptor Protein Signaling Pathway Protein Kinase Activity Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cell Motility Regulation Of Cell Communication Regulation Of Signaling Kinase Activity Regulation Of Locomotion Regulation Of Cell Population Proliferation Regulation Of Developmental Process Regulation Of Cell Migration Positive Regulation Of Cell Migration Regulation Of Multicellular Organismal Process Positive Regulation Of Cell Motility Positive Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Protein Tyrosine Kinase Activity Positive Regulation Of Locomotion Positive Regulation Of Cell Communication Positive Regulation Of Signaling Cell Differentiation Intracellular Signal Transduction Protein Phosphorylation Animal Organ Development Developmental Process Regulation Of Growth Cellular Developmental Process Response To Growth Factor Phosphorylation Regulation Of Protein Phosphorylation Positive Regulation Of Intracellular Signal Transduction Regulation Of Protein Modification Process ATP Binding Cellular Response To Growth Factor Stimulus Regulation Of MAPK Cascade Regulation Of Multicellular Organismal Development Regulation Of Cell Differentiation Regulation Of Phosphorylation Positive Regulation Of Developmental Process Cell Migration Positive Regulation Of Cell Population Proliferation Positive Regulation Of Growth Regulation Of Cell Growth Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Phosphorus Metabolic Process Positive Regulation Of Cell Differentiation Regulation Of Programmed Cell Death	Protein Kinase Binding Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Immune Response-regulating Signaling Pathway Regulation Of Immune System Process Cellular Response To Cytokine Stimulus Fc-epsilon Receptor Signaling Pathway Stress-activated Protein Kinase Signaling Cascade Stress-activated MAPK Cascade Negative Regulation Of Phosphate Metabolic Process Response To Cytokine Response To Peptide Regulation Of Intracellular Signal Transduction Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Signal Transduction Involved In Regulation Of Gene Expression Positive Regulation Of Canonical NF-kappaB Signal Transduction Intracellular Receptor Signaling Pathway MAPK Cascade Negative Regulation Of Cytokine Production Involved In Inflammatory Response Antigen Processing And Presentation Of Exogenous Antigen Regulation Of RNA Metabolic Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Negative Regulation Of Intracellular Signal Transduction Fc Receptor Signaling Pathway Canonical NF-kappaB Signal Transduction JNK Cascade MRNA Transcription Lactoylglutathione Lyase Activity Antigen Processing And Presentation Of Peptide Antigen Regulation Of Canonical NF-kappaB Signal Transduction Response To Lipid Dentate Gyrus Mossy Fiber NADH-dependent Peroxiredoxin Activity Regulation Of Nucleobase-containing Compound Metabolic Process Cytosol Negative Regulation Of Apoptotic Process Intracellular Signaling Cassette Immune Response-activating Signaling Pathway Negative Regulation Of Kinase Activity Negative Regulation Of Programmed Cell Death Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Cytokine Production Involved In Inflammatory Response Cytokine-mediated Signaling Pathway Positive Regulation Of Monocyte Aggregation