CD44 and ABCB5

Number of citations of the paper that reports this interaction (PubMedID 28205554)
55

Data Source:
BioGRID (fluorescent resonance energy transfer)

		CD44	ABCB5
Description		CD44 molecule (IN blood group)	ATP binding cassette subfamily B member 5
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Golgi Apparatus Cytosol Plasma Membrane Microvillus Focal Adhesion Cell Surface Membrane Basolateral Plasma Membrane Apical Plasma Membrane Secretory Granule Membrane Lamellipodium Membrane Protein-containing Complex Macrophage Migration Inhibitory Factor Receptor Complex Cell Projection Extracellular Exosome	Plasma Membrane Membrane Apical Plasma Membrane
	Molecular Function	Transmembrane Signaling Receptor Activity Cytokine Receptor Activity Protein Binding Collagen Binding Hyaluronic Acid Binding	Nucleotide Binding ATP Binding ABC-type Xenobiotic Transporter Activity Efflux Transmembrane Transporter Activity ATP Hydrolysis Activity ATPase-coupled Transmembrane Transporter Activity ABC-type Transporter Activity
	Biological Process	Inflammatory Response Cell Adhesion Cell-matrix Adhesion Anatomical Structure Morphogenesis Cell Migration Cytokine-mediated Signaling Pathway Hyaluronan Catabolic Process Positive Regulation Of Heterotypic Cell-cell Adhesion T Cell Activation Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Wound Healing, Spreading Of Cells Cellular Response To Fibroblast Growth Factor Stimulus System Development Cartilage Development Positive Regulation Of ERK1 And ERK2 Cascade Monocyte Aggregation Cell-cell Adhesion Positive Regulation Of Monocyte Aggregation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Regulation Of Lamellipodium Morphogenesis	Eye Development Cell Differentiation Regulation Of Membrane Potential Xenobiotic Transport Transmembrane Transport
Pathways		Degradation of the extracellular matrix Cell surface interactions at the vascular wall Hyaluronan metabolism Integrin cell surface interactions Hyaluronan degradation Neutrophil degranulation Interferon gamma signaling Developmental Lineage of Mammary Gland Luminal Epithelial Cells Developmental Lineage of Mammary Gland Myoepithelial Cells Developmental Lineage of Mammary Stem Cells	ABC-family proteins mediated transport
Drugs		Bivatuzumab Hyaluronic acid	Biricodar Dofequidar
Diseases		Gastric cancer
GWAS		Bone mineral density (hip) ( 30172743) Glycemic traits (pleiotropy) ( 31021400) Intake of sweets ( 31005972) Response to Vitamin E supplementation ( 22437554) Systemic lupus erythematosus ( 23273568 26502338 27399966 28714469) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010) Total body bone mineral density ( 29304378) Uterine fibroids ( 31649266) Vitiligo ( 22561518 27723757)	Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 31361310) Asthma ( 34103634 32296059 31959851 30929738) Asthma (childhood onset) ( 31036433 30929738) Asthma onset (childhood vs adult) ( 30929738) Cough in response to angiotensin-converting enzyme inhibitor drugs ( 28084903) Dental caries ( 23259602) Eosinophil count ( 29403010) Femur bone mineral density x serum urate levels interaction ( 34046847) PR interval in Tripanosoma cruzi seropositivity ( 24324551) Prostate cancer ( 23535732) Response to statin therapy ( 20339536) Type 1 diabetes ( 34127860) Waist circumference adjusted for body mass index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		61 interacting genes: ABCB1 ABCB5 AKT1 ANK1 ANXA1 ARHGEF1 ARHGEF12 ARNT CCND2 CD4 CD74 CDK4 CDK6 CDKN2A CDKN2B COL14A1 COL1A1 COL1A2 CSK DMP1 EGFR EPB41 EPHA2 ERBB4 EZR FGF2 FGFR4 FN1 FYN GARS1 GLIS2 GRM1 HBEGF HMMR IGFBP3 KDELR2 LATS2 LCK MADCAM1 MAP2K3 MAP2K5 MDM4 MET MMP1 MMP7 MMP9 NF2 PDGFRA PKN1 RAF1 SELE SPP1 SRC SRGN STK11 TGFBR1 TGFBR2 TIAM1 VAV2 VCAN VHL	8 interacting genes: CCND2 CD44 EPHA2 ERBB2 FGFR4 PSMB5 RAF1 STK11
Entrez ID		960	340273
HPRD ID		00115	12402
Ensembl ID		ENSG00000026508	ENSG00000004846
Uniprot IDs		P16070	Q2M3G0
PDB IDs		1POZ 1UUH 2I83 4PZ3 4PZ4 6TXS
Enriched GO Terms of Interacting Partners?		Enzyme-linked Receptor Protein Signaling Pathway Protein Kinase Activity Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cell Motility Regulation Of Cell Communication Regulation Of Signaling Kinase Activity Regulation Of Locomotion Regulation Of Cell Population Proliferation Regulation Of Developmental Process Regulation Of Cell Migration Positive Regulation Of Cell Migration Regulation Of Multicellular Organismal Process Positive Regulation Of Cell Motility Positive Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Protein Tyrosine Kinase Activity Positive Regulation Of Locomotion Positive Regulation Of Cell Communication Positive Regulation Of Signaling Cell Differentiation Intracellular Signal Transduction Protein Phosphorylation Animal Organ Development Developmental Process Regulation Of Growth Cellular Developmental Process Response To Growth Factor Phosphorylation Regulation Of Protein Phosphorylation Positive Regulation Of Intracellular Signal Transduction Regulation Of Protein Modification Process ATP Binding Cellular Response To Growth Factor Stimulus Regulation Of MAPK Cascade Regulation Of Multicellular Organismal Development Regulation Of Cell Differentiation Regulation Of Phosphorylation Positive Regulation Of Developmental Process Cell Migration Positive Regulation Of Cell Population Proliferation Positive Regulation Of Growth Regulation Of Cell Growth Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Phosphorus Metabolic Process Positive Regulation Of Cell Differentiation Regulation Of Programmed Cell Death	Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Kinase Activity Regulation Of ERK1 And ERK2 Cascade Regulation Of MAPK Cascade Kinase Activity Positive Regulation Of Catalytic Activity ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway Protein Phosphorylation Phosphorylation Protein Tyrosine Kinase Activity Positive Regulation Of MAPK Cascade Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Schwann Cell Development Lamellipodium Membrane Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction ERBB2 Signaling Pathway Epithelial Cell Proliferation Regulation Of Catalytic Activity Receptor Complex Carbohydrate Homeostasis Glucose Homeostasis Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Phosphorylation Phosphate-containing Compound Metabolic Process ATP Binding Positive Regulation Of Phosphorylation Regulation Of Cellular Component Organization Growth Factor Binding Cell Population Proliferation Regulation Of Lamellipodium Organization Peptidyl-tyrosine Phosphorylation Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Response To Growth Factor Positive Regulation Of Phosphate Metabolic Process Apoptotic Signaling Pathway Regulation Of Cell Population Proliferation Negative Regulation Of Apoptotic Process Regulation Of Anatomical Structure Morphogenesis Glial Cell Development Negative Regulation Of Programmed Cell Death Nucleotide Binding Transferase Activity Notochord Cell Development Positive Regulation Of Cell Communication Positive Regulation Of Signaling Wound Healing Positive Regulation Of Protein Modification Process
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?