CD44 and SELE

Number of citations of the paper that reports this interaction (PubMedID 11402070)
41

Data Source:
HPRD (in vivo, in vitro)

		CD44	SELE
Description		CD44 molecule (IN blood group)	selectin E
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GO Annotations	Cellular Component	Extracellular Region Golgi Apparatus Cytosol Plasma Membrane Microvillus Focal Adhesion Cell Surface Membrane Basolateral Plasma Membrane Apical Plasma Membrane Secretory Granule Membrane Lamellipodium Membrane Protein-containing Complex Macrophage Migration Inhibitory Factor Receptor Complex Cell Projection Extracellular Exosome	Extracellular Space Plasma Membrane Caveola Clathrin-coated Pit External Side Of Plasma Membrane Membrane Cortical Cytoskeleton Membrane Raft Perinuclear Region Of Cytoplasm
	Molecular Function	Transmembrane Signaling Receptor Activity Cytokine Receptor Activity Protein Binding Collagen Binding Hyaluronic Acid Binding	Transmembrane Signaling Receptor Activity Protein Binding Carbohydrate Binding Sialic Acid Binding Phospholipase Binding Metal Ion Binding Oligosaccharide Binding
	Biological Process	Inflammatory Response Cell Adhesion Cell-matrix Adhesion Anatomical Structure Morphogenesis Cell Migration Cytokine-mediated Signaling Pathway Hyaluronan Catabolic Process Positive Regulation Of Heterotypic Cell-cell Adhesion T Cell Activation Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Wound Healing, Spreading Of Cells Cellular Response To Fibroblast Growth Factor Stimulus System Development Cartilage Development Positive Regulation Of ERK1 And ERK2 Cascade Monocyte Aggregation Cell-cell Adhesion Positive Regulation Of Monocyte Aggregation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Regulation Of Lamellipodium Morphogenesis	Positive Regulation Of Receptor Internalization Leukocyte Migration Involved In Inflammatory Response Positive Regulation Of Leukocyte Migration Inflammatory Response Cell Adhesion Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Leukocyte Cell-cell Adhesion Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Calcium-mediated Signaling Actin Filament-based Process Response To Lipopolysaccharide Response To Cytokine Response To Tumor Necrosis Factor Regulation Of Inflammatory Response Leukocyte Migration Leukocyte Tethering Or Rolling Response To Interleukin-1 Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Positive Regulation Of Leukocyte Tethering Or Rolling
Pathways		Degradation of the extracellular matrix Cell surface interactions at the vascular wall Hyaluronan metabolism Integrin cell surface interactions Hyaluronan degradation Neutrophil degranulation Interferon gamma signaling Developmental Lineage of Mammary Gland Luminal Epithelial Cells Developmental Lineage of Mammary Gland Myoepithelial Cells Developmental Lineage of Mammary Stem Cells	Cell surface interactions at the vascular wall
Drugs		Bivatuzumab Hyaluronic acid	Carvedilol N-acetyl-alpha-neuraminic acid Endostatin
Diseases		Gastric cancer
GWAS		Bone mineral density (hip) ( 30172743) Glycemic traits (pleiotropy) ( 31021400) Intake of sweets ( 31005972) Response to Vitamin E supplementation ( 22437554) Systemic lupus erythematosus ( 23273568 26502338 27399966 28714469) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010) Total body bone mineral density ( 29304378) Uterine fibroids ( 31649266) Vitiligo ( 22561518 27723757)	Blood protein levels ( 30072576) Inflammatory bowel disease ( 26192919) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494)
Interacting Genes		61 interacting genes: ABCB1 ABCB5 AKT1 ANK1 ANXA1 ARHGEF1 ARHGEF12 ARNT CCND2 CD4 CD74 CDK4 CDK6 CDKN2A CDKN2B COL14A1 COL1A1 COL1A2 CSK DMP1 EGFR EPB41 EPHA2 ERBB4 EZR FGF2 FGFR4 FN1 FYN GARS1 GLIS2 GRM1 HBEGF HMMR IGFBP3 KDELR2 LATS2 LCK MADCAM1 MAP2K3 MAP2K5 MDM4 MET MMP1 MMP7 MMP9 NF2 PDGFRA PKN1 RAF1 SELE SPP1 SRC SRGN STK11 TGFBR1 TGFBR2 TIAM1 VAV2 VCAN VHL	16 interacting genes: ACTA2 ACTN2 CD44 FLNA GLG1 LGALS3BP PLCG1 PTK2 PTPN11 PXN SELL SELPLG SERPING1 SNCA TRIM54 VCL
Entrez ID		960	6401
HPRD ID		00115	00566
Ensembl ID		ENSG00000026508	ENSG00000007908
Uniprot IDs		P16070	P16581
PDB IDs		1POZ 1UUH 2I83 4PZ3 4PZ4 6TXS	1ESL 1G1T 4C16 4CSY 6EYI 6EYJ 6EYK 8R5L 8R5M
Enriched GO Terms of Interacting Partners?		Enzyme-linked Receptor Protein Signaling Pathway Protein Kinase Activity Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cell Motility Regulation Of Cell Communication Regulation Of Signaling Kinase Activity Regulation Of Locomotion Regulation Of Cell Population Proliferation Regulation Of Developmental Process Regulation Of Cell Migration Positive Regulation Of Cell Migration Regulation Of Multicellular Organismal Process Positive Regulation Of Cell Motility Positive Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Protein Tyrosine Kinase Activity Positive Regulation Of Locomotion Positive Regulation Of Cell Communication Positive Regulation Of Signaling Cell Differentiation Intracellular Signal Transduction Protein Phosphorylation Animal Organ Development Developmental Process Regulation Of Growth Cellular Developmental Process Response To Growth Factor Phosphorylation Regulation Of Protein Phosphorylation Positive Regulation Of Intracellular Signal Transduction Regulation Of Protein Modification Process ATP Binding Cellular Response To Growth Factor Stimulus Regulation Of MAPK Cascade Regulation Of Multicellular Organismal Development Regulation Of Cell Differentiation Regulation Of Phosphorylation Positive Regulation Of Developmental Process Cell Migration Positive Regulation Of Cell Population Proliferation Positive Regulation Of Growth Regulation Of Cell Growth Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Phosphorus Metabolic Process Positive Regulation Of Cell Differentiation Regulation Of Programmed Cell Death	Cell Adhesion Cell Migration Cytoskeleton Focal Adhesion Cell Motility Cellular Response To Growth Factor Stimulus Actin Cytoskeleton Positive Regulation Of Cation Transmembrane Transport Positive Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Cytoskeleton Organization Response To Growth Factor Actin Binding Regulation Of Supramolecular Fiber Organization Leukocyte Cell-cell Adhesion Cell Cortex Positive Regulation Of Monoatomic Ion Transport Signal Complex Assembly Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Stress Fiber Cell Projection Cell-cell Adhesion Regulation Of Monoatomic Cation Transmembrane Transport Positive Regulation Of Fibroblast Migration Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Cellular Component Organization Immune System Process Regulation Of Monoatomic Ion Transmembrane Transport Leukocyte Tethering Or Rolling Megakaryocyte Development Leukocyte Adhesion To Vascular Endothelial Cell Extracellular Exosome Regulation Of Metal Ion Transport Z Disc Regulation Of Sequestering Of Calcium Ion Enzyme-linked Receptor Protein Signaling Pathway Growth Hormone Receptor Signaling Pathway Regulation Of Locomotion Wound Healing, Spreading Of Cells Regulation Of Actin Filament-based Process Cellular Response To Fibroblast Growth Factor Stimulus Protein Localization To Cell Surface Cell-substrate Adhesion Regulation Of Multicellular Organismal Process Protein-containing Complex Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Potassium Ion Transport Regulation Of Organelle Organization Plasma Membrane Regulation Of Monoatomic Ion Transport
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