FAM114A1 and SPG21

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		FAM114A1	SPG21
Gene Name		family with sequence similarity 114, member A1	spastic paraplegia 21 (autosomal recessive, Mast syndrome)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm	Nucleus Nucleoplasm Cytoplasm Cytosol Endosome Membrane Trans-Golgi Network Transport Vesicle
	Molecular Function		Protein Binding CD4 Receptor Binding
	Biological Process		Antigen Receptor-mediated Signaling Pathway
Pathways
Drugs
Diseases
GWAS		Helicobacter pylori serologic status ( 23652523)
Protein-Protein Interactions		5 interactors: AGTRAP CMTM5 RAB2A RAB2B SPG21	37 interactors: AGTRAP AKIRIN2 ARL6IP1 ATPAF2 CCDC102B CCDC33 CD4 CMTM5 CRYAA CTPS2 CUTC DTX2 DTX3L EFHC2 FAM114A1 GGA2 GSK3A IKZF3 INCA1 KRT15 MID2 MTMR9 PRPS1 RABAC1 REEP6 RTN4 S100B SPRED2 TCF12 TCF4 TFG TRAF1 TRAF2 TRIM23 TRIM54 TRIM9 ZNF263
Entrez ID		92689	51324
HPRD ID		11282	10492
Ensembl ID		ENSG00000197712	ENSG00000090487
Uniprot IDs		Q8IWE2	Q9NZD8
PDB IDs
Enriched GO Terms of Interacting Partners?		Rab Protein Signal Transduction Ras Protein Signal Transduction Angiotensin-activated Signaling Pathway	Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Apoptotic Process Protein Ubiquitination Regulation Of Cell Death Protein Modification By Small Protein Conjugation Negative Regulation Of Developmental Growth Innate Immune Response Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Striated Muscle Tissue Development Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Interleukin-2 Production Positive Regulation Of Cell Death Immune Response Negative Regulation Of Organ Growth Negative Regulation Of UDP-glucose Catabolic Process Induction By Virus Of Host Cell-cell Fusion Protein Palmitoleylation Regulation Of Intracellular Signal Transduction Negative Regulation Of Muscle Cell Differentiation Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Striated Muscle Tissue Development Regulation Of Cellular Localization Negative Regulation Of Muscle Organ Development Regulation Of Signal Transduction Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Pyrimidine Nucleotide Biosynthetic Process Regulation Of Intracellular Transport Negative Regulation Of Cell Differentiation Regulation Of Protein Kinase Activity Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Type B Pancreatic Cell Development Negative Regulation Of SNARE Complex Assembly Catenin Import Into Nucleus Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition Urate Biosynthetic Process 'de Novo' CTP Biosynthetic Process Glycogen Metabolic Process Regulation Of Kinase Activity Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Cell Differentiation Positive Regulation Of Protein Binding Regulation Of Skeletal Muscle Tissue Development Regulation Of Cellular Ketone Metabolic Process Gliogenesis Negative Regulation Of Growth Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process
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