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CD8A and SREK1
Number of citations of the paper that reports this interaction (PubMedID
14559993
)
73
Data Source:
HPRD
(two hybrid, in vitro, in vivo)
CD8A
SREK1
Description
CD8 subunit alpha
splicing regulatory glutamic acid and lysine rich protein 1
Image
No pdb structure
GO Annotations
Cellular Component
Extracellular Region
Plasma Membrane
External Side Of Plasma Membrane
Membrane
T Cell Receptor Complex
Receptor Complex
Plasma Membrane Raft
Nucleus
Nucleoplasm
Spliceosomal Complex
Nuclear Speck
Molecular Function
Protein Binding
Coreceptor Activity
MHC Class I Protein Complex Binding
MHC Class I Protein Binding
Nucleic Acid Binding
RNA Binding
Protein Binding
Biological Process
Adaptive Immune Response
Immune System Process
T Cell Mediated Immunity
Immune Response
Cell Surface Receptor Signaling Pathway
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Antigen Processing And Presentation
T Cell Activation
Cytotoxic T Cell Differentiation
T Cell Receptor Signaling Pathway
MRNA Processing
RNA Splicing
Pathways
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Drugs
Diseases
Combined immunodeficiencies (CIDs), including the following nine diseases: X-linked hyper IgM syndrome; CD40 deficiency hyper IgM syndrome; Purine nucleoside phosphorylase (PNP) deficiency; Omenn syndrome; MHC deficiency (HLA-class I); MHC deficiency (HLA-class II); Zap-70 deficiency; p56 Lck deficiency; CD8 deficiency
GWAS
Blood protein levels (
30072576
)
Logical memory (delayed recall) in mild cognitive impairment (
29274321
)
Systolic blood pressure (
30224653
)
Interacting Genes
17 interacting genes:
B2M
CACYBP
CD3D
CD59
CD8B
CDK1
HLA-A
HLA-B
HLA-C
HLA-E
HLA-G
LAT
LCK
LGALS1
PTPRC
SREK1
SRSF1
66 interacting genes:
ARL6IP4
CD8A
CKAP2
CSNK2A1
DDX17
DDX39B
DDX3X
DGKA
DGKD
EFTUD2
ELAVL1
GPRASP2
HNRNPA1
HNRNPA2B1
HNRNPA3
HNRNPC
HNRNPD
HNRNPH1
HNRNPK
HNRNPU
ILF2
MDM2
MRPL37
NAT10
NCL
NPM1
PABPC1
PABPC4
PARP1
PCBP3
PIN1
PRPF40A
RAB5C
RACK1
RBM10
RBM39
RBMX
SAFB
SF3A3
SF3B3
SFPQ
SH3GLB2
SNRPD1
SNRPD3
SRPK1
SRPK2
SRPK3
SRRM4
SRSF1
SRSF10
SRSF11
SRSF2
SRSF3
SRSF4
SRSF5
SRSF6
SRSF7
SRSF8
SSRP1
SUPT16H
TARBP1
THRAP3
TRA2B
TXLNA
YBX1
ZRANB2
Entrez ID
925
140890
HPRD ID
01737
18043
Ensembl ID
ENSG00000153563
ENSG00000153914
Uniprot IDs
P01732
Q6ZVS2
Q8TAW8
Q8WXA9
PDB IDs
1AKJ
1CD8
1Q69
2HP4
3QZW
7UMG
7UVF
8EW6
Enriched GO Terms of Interacting Partners
?
MHC Class I Protein Complex
Positive Regulation Of T Cell Mediated Cytotoxicity
Regulation Of T Cell Mediated Cytotoxicity
Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I
ER To Golgi Transport Vesicle Membrane
Positive Regulation Of Immune Response
Antigen Processing And Presentation Of Endogenous Antigen
Positive Regulation Of Leukocyte Mediated Cytotoxicity
Positive Regulation Of Cell Killing
Positive Regulation Of T Cell Mediated Immunity
Regulation Of Immune Response
Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I
Peptide Antigen Binding
Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent
Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class Ib
Positive Regulation Of Immune System Process
Regulation Of Leukocyte Mediated Cytotoxicity
Adaptive Immune Response
Regulation Of T Cell Mediated Immunity
Protection From Natural Killer Cell Mediated Cytotoxicity
Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains
External Side Of Plasma Membrane
Regulation Of Adaptive Immune Response
Positive Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains
Antigen Processing And Presentation Of Peptide Antigen
Positive Regulation Of Lymphocyte Mediated Immunity
Positive Regulation Of Adaptive Immune Response
Lumenal Side Of Endoplasmic Reticulum Membrane
Phagocytic Vesicle Membrane
Lymphocyte Activation
Regulation Of Immune System Process
T Cell Activation
Antigen Processing And Presentation
Recycling Endosome Membrane
Regulation Of Lymphocyte Mediated Immunity
TAP Binding
Early Endosome Membrane
T Cell Receptor Signaling Pathway
Negative Regulation Of Immune Response
Regulation Of Natural Killer Cell Mediated Cytotoxicity
Leukocyte Activation
Immune System Process
Regulation Of T Cell Activation
CD8 Receptor Binding
Regulation Of Natural Killer Cell Mediated Immunity
Positive Regulation Of T Cell Activation
Positive Regulation Of Immune Effector Process
Cell Activation
Antigen Receptor-mediated Signaling Pathway
Immune Response-regulating Cell Surface Receptor Signaling Pathway
RNA Splicing
RNA Binding
MRNA Processing
MRNA Metabolic Process
RNA Processing
Regulation Of MRNA Processing
Regulation Of MRNA Metabolic Process
RNA Metabolic Process
Regulation Of MRNA Splicing, Via Spliceosome
Nucleic Acid Binding
Regulation Of RNA Splicing
RNA Splicing, Via Transesterification Reactions
Nucleic Acid Metabolic Process
MRNA Splicing, Via Spliceosome
Nucleobase-containing Compound Metabolic Process
Regulation Of Alternative MRNA Splicing, Via Spliceosome
MRNA Binding
Nuclear Speck
Negative Regulation Of MRNA Metabolic Process
Catalytic Step 2 Spliceosome
Spliceosomal Complex
Ribonucleoprotein Complex
Nucleoplasm
Nucleus
Macromolecule Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of RNA Metabolic Process
Negative Regulation Of MRNA Splicing, Via Spliceosome
Negative Regulation Of RNA Splicing
Regulation Of Primary Metabolic Process
MRNA Stabilization
Regulation Of Gene Expression
Spliceosomal Complex Assembly
Protein-RNA Complex Assembly
Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of MRNA Catabolic Process
RNA Stabilization
Regulation Of Macromolecule Metabolic Process
Negative Regulation Of RNA Catabolic Process
Regulation Of MRNA Stability
Regulation Of RNA Stability
Alternative MRNA Splicing, Via Spliceosome
Post-transcriptional Regulation Of Gene Expression
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Telomere Maintenance Via Telomere Lengthening
Regulation Of Metabolic Process
Negative Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Gene Expression
Pre-mRNA Binding
Negative Regulation Of Macromolecule Biosynthetic Process
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