CD8A and SREK1

Number of citations of the paper that reports this interaction (PMID 14559993)
9

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		CD8A	SREK1
Gene Name		CD8a molecule	splicing regulatory glutamine/lysine-rich protein 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane T Cell Receptor Complex	Nucleoplasm Spliceosomal Complex
	Molecular Function	Protein Binding Coreceptor Activity Protein Kinase Binding MHC Class I Protein Binding Protein Homodimerization Activity	Nucleotide Binding Poly(A) RNA Binding
	Biological Process	T Cell Mediated Immunity Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Antigen Processing And Presentation T Cell Activation Cytotoxic T Cell Differentiation Regulation Of Immune Response Positive Regulation Of Calcium-mediated Signaling Defense Response To Virus	MRNA Processing RNA Splicing
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		17 interactors: B2M CACYBP CD3D CD59 CD8B CDK1 HLA-A HLA-B HLA-C HLA-E HLA-G LAT LCK LGALS1 PTPRC SREK1 SRSF1	55 interactors: CD8A CSNK2A1 DDX17 DDX39B DDX3X DGKA DGKD EFTUD2 ELAVL1 GNB2L1 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPC HNRNPD HNRNPH1 HNRNPK HNRNPU ILF2 MDM2 NCL NPM1 PABPC1 PABPC4 PARP1 PIN1 RBM10 RBMX SAFB SF3A3 SF3B3 SFPQ SH3GLB2 SNRPD1 SNRPD3 SRPK1 SRPK2 SRPK3 SRSF1 SRSF10 SRSF11 SRSF2 SRSF3 SRSF4 SRSF5 SRSF6 SRSF7 SRSF8 SSRP1 SUPT16H TARBP1 THRAP3 TRA2B YBX1 ZRANB2
Entrez ID		925	140890
HPRD ID		01737	18043
Ensembl ID		ENSG00000153563	ENSG00000153914
Uniprot IDs		P01732 Q6ZVS2 Q8TAW8	E5RFV3 Q8WXA9
PDB IDs		1AKJ 1CD8 1Q69 2HP4 3QZW
Enriched GO Terms of Interacting Partners?		Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-independent Positive Regulation Of T Cell Mediated Cytotoxicity Regulation Of T Cell Mediated Cytotoxicity Regulation Of Immune Response Positive Regulation Of Immune System Process Positive Regulation Of Leukocyte Mediated Cytotoxicity Regulation Of Immune System Process Positive Regulation Of T Cell Mediated Immunity Positive Regulation Of Cell Killing Regulation Of Leukocyte Mediated Cytotoxicity Positive Regulation Of Immune Response Positive Regulation Of Adaptive Immune Response Immune System Process Immune Response Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Regulation Of Adaptive Immune Response Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Interferon-gamma-mediated Signaling Pathway Regulation Of T Cell Activation Innate Immune Response Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Cellular Response To Interferon-gamma Positive Regulation Of T Cell Activation Regulation Of Cell-cell Adhesion Positive Regulation Of Homotypic Cell-cell Adhesion Regulation Of Lymphocyte Activation Defense Response Response To Interferon-gamma Antigen Processing And Presentation Of Endogenous Antigen Positive Regulation Of Cell-cell Adhesion Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent Protection From Natural Killer Cell Mediated Cytotoxicity Type I Interferon Signaling Pathway Cellular Response To Type I Interferon Regulation Of Cell Activation Response To Type I Interferon Positive Regulation Of Cell Activation Antigen Processing And Presentation Of Peptide Antigen Regulation Of Defense Response To Virus By Virus Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Cell Adhesion Regulation Of Cell Adhesion Cell Surface Receptor Signaling Pathway Lymphocyte Activation Antigen Processing And Presentation Cell Activation Negative Regulation Of Immune Response Leukocyte Activation T Cell Aggregation T Cell Activation	RNA Splicing RNA Processing MRNA Processing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions MRNA Metabolic Process Gene Expression RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Regulation Of MRNA Processing Regulation Of MRNA Splicing, Via Spliceosome Regulation Of RNA Splicing RNA Export From Nucleus Termination Of RNA Polymerase II Transcription RNA Transport MRNA Export From Nucleus RNA Localization MRNA 3'-end Processing Nuclear Export MRNA Transport Cellular Metabolic Process RNA 3'-end Processing DNA-templated Transcription, Termination Ribonucleoprotein Complex Assembly Regulation Of MRNA Stability Regulation Of RNA Stability Nucleocytoplasmic Transport Nuclear Transport Spliceosomal Complex Assembly Regulation Of Gene Expression Negative Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of RNA Splicing MRNA Stabilization Regulation Of RNA Metabolic Process Positive Regulation Of Gene Expression Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process Metabolic Process Ribonucleoprotein Complex Biogenesis Transcription, DNA-templated Posttranscriptional Regulation Of Gene Expression RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Cytoplasmic Transport Positive Regulation Of Cellular Biosynthetic Process
Tagcloud ?		anthracycline assignment bcs carboplatin cb ccl5 cd21 cd80 ctla4 cxcl13 cxcl9 foxp3 geparsixto hierarchic histopathologic ido1 igkc immunogenicity immunologic immunologically infiltrating lpbc ors pmcb standardization taxane tils tn univariable
Tagcloud (Difference) ?		anthracycline assignment bcs carboplatin cb ccl5 cd21 cd80 ctla4 cxcl13 cxcl9 foxp3 geparsixto hierarchic histopathologic ido1 igkc immunogenicity immunologic immunologically infiltrating lpbc ors pmcb standardization taxane tils tn univariable
Tagcloud (Intersection) ?