CD8A

Name	CD8 subunit alpha
Structure
Novel Interactors	2 novel interactors: GGCX MRPS5
Interactors	17 interactors: B2M CACYBP CD3D CD59 CD8B CDK1 HLA-A HLA-B HLA-C HLA-E HLA-G LAT LCK LGALS1 PTPRC SREK1 SRSF1
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane External Side Of Plasma Membrane Membrane T Cell Receptor Complex Receptor Complex Plasma Membrane Raft
	Molecular Function	Protein Binding Coreceptor Activity MHC Class I Protein Complex Binding MHC Class I Protein Binding
	Biological Process	Adaptive Immune Response Immune System Process T Cell Mediated Immunity Immune Response Cell Surface Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Antigen Processing And Presentation T Cell Activation Cytotoxic T Cell Differentiation T Cell Receptor Signaling Pathway
Pathways	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Diseases	Combined immunodeficiencies (CIDs), including the following nine diseases: X-linked hyper IgM syndrome; CD40 deficiency hyper IgM syndrome; Purine nucleoside phosphorylase (PNP) deficiency; Omenn syndrome; MHC deficiency (HLA-class I); MHC deficiency (HLA-class II); Zap-70 deficiency; p56 Lck deficiency; CD8 deficiency
GWAS	Blood protein levels ( 30072576 )
Entrez ID	925
HPRD ID	01737
Ensembl ID	ENSG00000153563
Uniprot IDs	P01732 Q6ZVS2 Q8TAW8
PDB IDs	1AKJ 1CD8 1Q69 2HP4 3QZW 7UMG 7UVF 8EW6
GO Terms Enriched among Interactors ?	MHC Class I Protein Complex Positive Regulation Of T Cell Mediated Cytotoxicity Regulation Of T Cell Mediated Cytotoxicity Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I ER To Golgi Transport Vesicle Membrane Positive Regulation Of Immune Response Antigen Processing And Presentation Of Endogenous Antigen Positive Regulation Of Leukocyte Mediated Cytotoxicity Positive Regulation Of Cell Killing Positive Regulation Of T Cell Mediated Immunity Regulation Of Immune Response Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Peptide Antigen Binding Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class Ib Positive Regulation Of Immune System Process Regulation Of Leukocyte Mediated Cytotoxicity Adaptive Immune Response Regulation Of T Cell Mediated Immunity Protection From Natural Killer Cell Mediated Cytotoxicity Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains External Side Of Plasma Membrane Regulation Of Adaptive Immune Response Positive Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Antigen Processing And Presentation Of Peptide Antigen Positive Regulation Of Lymphocyte Mediated Immunity Positive Regulation Of Adaptive Immune Response Lumenal Side Of Endoplasmic Reticulum Membrane Phagocytic Vesicle Membrane Lymphocyte Activation Regulation Of Immune System Process T Cell Activation Antigen Processing And Presentation Recycling Endosome Membrane Regulation Of Lymphocyte Mediated Immunity TAP Binding Early Endosome Membrane T Cell Receptor Signaling Pathway Negative Regulation Of Immune Response Regulation Of Natural Killer Cell Mediated Cytotoxicity Leukocyte Activation Immune System Process Regulation Of T Cell Activation CD8 Receptor Binding Regulation Of Natural Killer Cell Mediated Immunity Positive Regulation Of T Cell Activation Positive Regulation Of Immune Effector Process Cell Activation Antigen Receptor-mediated Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway