CD8A and CD59

Number of citations of the paper that reports this interaction (PubMedID 1377690)
0

Data Source:
BioGRID (pull down)

		CD8A	CD59
Description		CD8 subunit alpha	CD59 molecule (CD59 blood group)
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GO Annotations	Cellular Component	Extracellular Region Plasma Membrane External Side Of Plasma Membrane Membrane T Cell Receptor Complex Receptor Complex Plasma Membrane Raft	Golgi Membrane Extracellular Region Extracellular Space Endoplasmic Reticulum Membrane Plasma Membrane Focal Adhesion External Side Of Plasma Membrane Cell Surface ER To Golgi Transport Vesicle Membrane Membrane Transport Vesicle Vesicle Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Specific Granule Membrane Extracellular Exosome Tertiary Granule Membrane Side Of Membrane
	Molecular Function	Protein Binding Coreceptor Activity MHC Class I Protein Complex Binding MHC Class I Protein Binding	Complement Binding Protein Binding Protein Sequestering Activity
	Biological Process	Adaptive Immune Response Immune System Process T Cell Mediated Immunity Immune Response Cell Surface Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Antigen Processing And Presentation T Cell Activation Cytotoxic T Cell Differentiation T Cell Receptor Signaling Pathway	Negative Regulation Of Activation Of Membrane Attack Complex Complement Activation Cell Surface Receptor Signaling Pathway Blood Coagulation Regulation Of Complement Activation Negative Regulation Of Complement Activation Regulation Of Complement-dependent Cytotoxicity Negative Regulation Of Complement-dependent Cytotoxicity
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	COPII-mediated vesicle transport Cargo concentration in the ER Neutrophil degranulation COPI-mediated anterograde transport Regulation of Complement cascade
Drugs
Diseases		Combined immunodeficiencies (CIDs), including the following nine diseases: X-linked hyper IgM syndrome; CD40 deficiency hyper IgM syndrome; Purine nucleoside phosphorylase (PNP) deficiency; Omenn syndrome; MHC deficiency (HLA-class I); MHC deficiency (HLA-class II); Zap-70 deficiency; p56 Lck deficiency; CD8 deficiency	Complement regulatory protein defects, including the following six diseases: C1 inhibitor deficiency (hereditary angioedema); C4 binding protein alpha deficiency; C4 binding protein beta deficiency; Factor I deficiency; Decay-accelerating factor (CD55) deficiency; CD59 deficiency
GWAS		Blood protein levels ( 30072576)	Blood protein levels ( 30072576) Body size at age 10 ( 32376654) Chronotype ( 30696823) Fruit consumption ( 32066663) Morning person ( 30696823)
Interacting Genes		17 interacting genes: B2M CACYBP CD3D CD59 CD8B CDK1 HLA-A HLA-B HLA-C HLA-E HLA-G LAT LCK LGALS1 PTPRC SREK1 SRSF1	16 interacting genes: C8A C9 CCR2 CD2 CD8A CD9 CHRM4 FAM209A GNAI3 NCR1 NCR3 SLC13A1 SLC6A8 SMAD4 SRC TMEM132D
Entrez ID		925	966
HPRD ID		01737	00117
Ensembl ID		ENSG00000153563	ENSG00000085063
Uniprot IDs		P01732 Q6ZVS2 Q8TAW8	P13987 Q6FHM9
PDB IDs		1AKJ 1CD8 1Q69 2HP4 3QZW 7UMG 7UVF 8EW6	1CDQ 1CDR 1CDS 1ERG 1ERH 2J8B 2OFS 2UWR 2UX2 4BIK 5IMT 5IMY 6ZD0 8B0F 8B0G 8B0H 8CN6
Enriched GO Terms of Interacting Partners?		MHC Class I Protein Complex Positive Regulation Of T Cell Mediated Cytotoxicity Regulation Of T Cell Mediated Cytotoxicity Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I ER To Golgi Transport Vesicle Membrane Positive Regulation Of Immune Response Antigen Processing And Presentation Of Endogenous Antigen Positive Regulation Of Leukocyte Mediated Cytotoxicity Positive Regulation Of Cell Killing Positive Regulation Of T Cell Mediated Immunity Regulation Of Immune Response Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Peptide Antigen Binding Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class Ib Positive Regulation Of Immune System Process Regulation Of Leukocyte Mediated Cytotoxicity Adaptive Immune Response Regulation Of T Cell Mediated Immunity Protection From Natural Killer Cell Mediated Cytotoxicity Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains External Side Of Plasma Membrane Regulation Of Adaptive Immune Response Positive Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Antigen Processing And Presentation Of Peptide Antigen Positive Regulation Of Lymphocyte Mediated Immunity Positive Regulation Of Adaptive Immune Response Lumenal Side Of Endoplasmic Reticulum Membrane Phagocytic Vesicle Membrane Lymphocyte Activation Regulation Of Immune System Process T Cell Activation Antigen Processing And Presentation Recycling Endosome Membrane Regulation Of Lymphocyte Mediated Immunity TAP Binding Early Endosome Membrane T Cell Receptor Signaling Pathway Negative Regulation Of Immune Response Regulation Of Natural Killer Cell Mediated Cytotoxicity Leukocyte Activation Immune System Process Regulation Of T Cell Activation CD8 Receptor Binding Regulation Of Natural Killer Cell Mediated Immunity Positive Regulation Of T Cell Activation Positive Regulation Of Immune Effector Process Cell Activation Antigen Receptor-mediated Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway	Cell Activation Membrane Attack Complex Regulation Of Immune System Process Other Organism Cell Membrane Membrane Natural Killer Cell Activation Positive Regulation Of Immune Response Regulation Of Immune Response Positive Regulation Of Immune System Process Immune Effector Process Activation Of Immune Response Complement Activation, GZMK Pathway Negative Regulation Of Adenylate Cyclase Activity Transmembrane Transporter Complex Complement Activation, Alternative Pathway Interleukin-6-mediated Signaling Pathway Plasma Membrane Uterus Development Leukocyte Activation Immune System Process External Side Of Plasma Membrane Negative Regulation Of Striated Muscle Cell Differentiation Cell Surface Receptor Signaling Pathway Complement Activation, Classical Pathway Cell Killing Cytotoxic T Cell Differentiation Immune Response-regulating Signaling Pathway Negative Regulation Of Cardiac Myofibril Assembly Positive Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Female Gonad Morphogenesis Creatine:sodium Symporter Activity L-cysteine-S-conjugate N-acetyltransferase Activity Negative Regulation Of Eosinophil Degranulation Positive Regulation Of Astrocyte Chemotaxis T-helper 17 Cell Chemotaxis Chemokine (C-C Motif) Ligand 12 Binding Chemokine (C-C Motif) Ligand 2 Binding Regulation Of Macrophage Migration Regulation Of Lymphocyte Mediated Immunity Immune Response Cellular Defense Response Lymphocyte Activation Dendrite Signal Transduction Negative Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Brain-derived Neurotrophic Factor Receptor Signaling Pathway Complement Activation Positive Regulation Of Myeloid Dendritic Cell Activation Gonad Morphogenesis Nephrogenic Mesenchyme Morphogenesis
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