CD8A and CD8B

Number of citations of the paper that reports this interaction (PMID 3145195)
28

Data Source:
BioGRID (imaging technique)
HPRD (in vivo, in vitro)

		CD8A	CD8B
Gene Name		CD8a molecule	CD8b molecule
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane T Cell Receptor Complex	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Early Endosome Membrane T Cell Receptor Complex
	Molecular Function	Protein Binding Coreceptor Activity Protein Kinase Binding MHC Class I Protein Binding Protein Homodimerization Activity	Protein Binding Coreceptor Activity MHC Class I Protein Binding
	Biological Process	T Cell Mediated Immunity Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Antigen Processing And Presentation T Cell Activation Cytotoxic T Cell Differentiation Regulation Of Immune Response Positive Regulation Of Calcium-mediated Signaling Defense Response To Virus	Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Viral Process T Cell Activation Regulation Of Defense Response To Virus By Virus Regulation Of Immune Response
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Adaptive Immune System	Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters HIV Infection Host Interactions of HIV factors Nef Mediated CD8 Down-regulation The role of Nef in HIV-1 replication and disease pathogenesis Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Adaptive Immune System
Drugs
Diseases
GWAS			Progressive supranuclear palsy ( 21685912)
Protein-Protein Interactions		17 interactors: B2M CACYBP CD3D CD59 CD8B CDK1 HLA-A HLA-B HLA-C HLA-E HLA-G LAT LCK LGALS1 PTPRC SREK1 SRSF1	3 interactors: CD3D CD8A ST3GAL4
Entrez ID		925	926
HPRD ID		01737	01725
Ensembl ID		ENSG00000153563	ENSG00000172116
Uniprot IDs		P01732 Q6ZVS2 Q8TAW8	P10966
PDB IDs		1AKJ 1CD8 1Q69 2HP4 3QZW
Enriched GO Terms of Interacting Partners?		Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-independent Positive Regulation Of T Cell Mediated Cytotoxicity Regulation Of T Cell Mediated Cytotoxicity Regulation Of Immune Response Positive Regulation Of Immune System Process Positive Regulation Of Leukocyte Mediated Cytotoxicity Regulation Of Immune System Process Positive Regulation Of T Cell Mediated Immunity Positive Regulation Of Cell Killing Regulation Of Leukocyte Mediated Cytotoxicity Positive Regulation Of Immune Response Positive Regulation Of Adaptive Immune Response Immune System Process Immune Response Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Regulation Of Adaptive Immune Response Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Interferon-gamma-mediated Signaling Pathway Regulation Of T Cell Activation Innate Immune Response Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Cellular Response To Interferon-gamma Positive Regulation Of T Cell Activation Regulation Of Cell-cell Adhesion Positive Regulation Of Homotypic Cell-cell Adhesion Regulation Of Lymphocyte Activation Defense Response Response To Interferon-gamma Antigen Processing And Presentation Of Endogenous Antigen Positive Regulation Of Cell-cell Adhesion Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent Protection From Natural Killer Cell Mediated Cytotoxicity Type I Interferon Signaling Pathway Cellular Response To Type I Interferon Regulation Of Cell Activation Response To Type I Interferon Positive Regulation Of Cell Activation Antigen Processing And Presentation Of Peptide Antigen Regulation Of Defense Response To Virus By Virus Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Cell Adhesion Regulation Of Cell Adhesion Cell Surface Receptor Signaling Pathway Lymphocyte Activation Antigen Processing And Presentation Cell Activation Negative Regulation Of Immune Response Leukocyte Activation T Cell Aggregation T Cell Activation	Cytotoxic T Cell Differentiation T Cell Differentiation Lymphocyte Differentiation T Cell Aggregation T Cell Activation Lymphocyte Aggregation Leukocyte Aggregation Leukocyte Cell-cell Adhesion Homotypic Cell-cell Adhesion Leukocyte Differentiation Lymphocyte Activation Positive Thymic T Cell Selection Leukocyte Activation Single Organismal Cell-cell Adhesion Hemopoiesis Cell Activation Immune System Development Thymic T Cell Selection Keratan Sulfate Biosynthetic Process Positive T Cell Selection Positive Regulation Of Calcium-mediated Signaling Keratan Sulfate Metabolic Process Regulation Of Immune Response T Cell Mediated Immunity T Cell Selection Regulation Of Calcium-mediated Signaling O-glycan Processing Sialylation Dolichol-linked Oligosaccharide Biosynthetic Process Cell Adhesion T Cell Differentiation In Thymus Regulation Of Immune System Process T Cell Costimulation Protein O-linked Glycosylation Glycosaminoglycan Biosynthetic Process Protein N-linked Glycosylation Via Asparagine
Tagcloud ?		anthracycline assignment bcs carboplatin cb ccl5 cd21 cd80 ctla4 cxcl13 cxcl9 foxp3 geparsixto hierarchic histopathologic ido1 igkc immunogenicity immunologic immunologically infiltrating lpbc ors pmcb standardization taxane tils tn univariable
Tagcloud (Difference) ?		anthracycline assignment bcs carboplatin cb ccl5 cd21 cd80 ctla4 cxcl13 cxcl9 foxp3 geparsixto hierarchic histopathologic ido1 igkc immunogenicity immunologic immunologically infiltrating lpbc ors pmcb standardization taxane tils tn univariable
Tagcloud (Intersection) ?