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DOK2 and POT1
Number of citations of the paper that reports this interaction (PubMedID
21044950
)
82
Data Source:
BioGRID
(two hybrid)
DOK2
POT1
Description
docking protein 2
protection of telomeres 1
Image
GO Annotations
Cellular Component
Cytoplasm
Cytosol
Plasma Membrane
Chromosome, Telomeric Region
Nuclear Telomere Cap Complex
Nucleus
Nucleoplasm
Chromosome
Shelterin Complex
Molecular Function
Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity
Protein Binding
DNA Binding
Protein Binding
Telomerase Inhibitor Activity
DEAD/H-box RNA Helicase Binding
Telomeric DNA Binding
Single-stranded Telomeric DNA Binding
Telomeric D-loop Binding
Telomeric G-quadruplex DNA Binding
G-rich Strand Telomeric DNA Binding
8-hydroxy-2'-deoxyguanosine DNA Binding
G-rich Single-stranded DNA Binding
Biological Process
Signal Transduction
Cell Surface Receptor Signaling Pathway
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Ras Protein Signal Transduction
Telomere Maintenance
Telomere Maintenance Via Telomerase
Telomere Capping
Telomere Assembly
Positive Regulation Of Telomere Maintenance
Regulation Of Telomere Maintenance Via Telomerase
Negative Regulation Of Telomere Maintenance Via Telomerase
Positive Regulation Of Telomere Maintenance Via Telomerase
Positive Regulation Of DNA Strand Elongation
Telomeric D-loop Disassembly
Establishment Of Protein Localization To Telomere
Positive Regulation Of Telomeric D-loop Disassembly
Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Pathways
Tie2 Signaling
RET signaling
Recognition and association of DNA glycosylase with site containing an affected pyrimidine
Cleavage of the damaged pyrimidine
Recognition and association of DNA glycosylase with site containing an affected purine
Recognition and association of DNA glycosylase with site containing an affected purine
Cleavage of the damaged purine
Cleavage of the damaged purine
Meiotic synapsis
Packaging Of Telomere Ends
Telomere Extension By Telomerase
Polymerase switching on the C-strand of the telomere
Processive synthesis on the C-strand of the telomere
Telomere C-strand (Lagging Strand) Synthesis
Telomere C-strand synthesis initiation
Removal of the Flap Intermediate from the C-strand
DNA Damage/Telomere Stress Induced Senescence
Inhibition of DNA recombination at telomere
Drugs
Diseases
GWAS
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
Entorhinal cortical thickness (
21116278
)
Lymphocyte count (
32888494
)
Mean corpuscular volume (
20139978
)
Mean platelet volume (
32888494
)
Metabolite levels (
23823483
)
Monocyte count (
32888494
)
Monocyte percentage of white cells (
32888494
)
Neuropathic pain in type 2 diabetes (
24974787
)
Neutrophil percentage of white cells (
32888494
)
Pancreatic cancer (
30206226
)
Platelet distribution width (
32888494
)
Refractive error (
32231278
)
Verbal declarative memory (
25648963
)
Chronic lymphocytic leukemia (
24292274
28165464
)
Cutaneous malignant melanoma (
26237428
)
Leukocyte telomere length (
31171785
32109421
)
Refractive error (
32231278
)
Response to selective serotonin reuptake inhibitors and depression (
27622933
)
Telomere length (
33941849
)
Interacting Genes
22 interacting genes:
ABL1
APPL1
CRK
CRKL
CSK
DOK3
EGFR
HCK
IL4R
INPP5D
KIFBP
LCK
LYN
NCK1
POT1
RASA1
RET
SRC
STAT3
TEK
TXK
YES1
166 interacting genes:
ACD
ACOT7
ACTB
ACTN4
ACY1
AFAP1L2
AHCY
AHNAK
AIPL1
ALDH1A1
ALDH3A1
AMPD2
ANKMY2
ANXA2
ANXA4
APPL2
ARHGDIA
ARID3B
ARRB1
BAG3
BCAS2
BIN2
C2orf74
CALD1
CAMK1D
CCDC32
CCDC9
CCM2
CFL1
CFL2
CKB
CLIC3
CNST
CORO1A
COX6A2
CPNE3
CPPED1
CRK
CRYGS
CSNK2B
CYP4F11
DBN1
DBNL
DCX
DDX19B
DNPH1
DOK2
DPP3
DPYSL3
ECI1
EEF1D
EIF3G
EIF4B
ENO2
ENSA
EPB41L1
EVL
FAM131B
FBP1
FES
GAMT
GAPDH
GAS2L1
GFPT2
GNMT
GPA33
GPR52
GRN
H2AC20
HAAO
HLCS
HMOX1
HNMT
HOXA3
HSP90AB1
HSPA1A
IFRD2
IL1RN
ISYNA1
IVL
KHDRBS1
KIAA1191
KRT18
LAMC3
LASP1
LDHA
LDHB
MADD
MAGEA4
MAP4
MAP4K2
MAP7
MDM2
MICA
MT1X
MVK
MVP
MYO5C
NAP1L1
NCDN
NOL3
NUDC
NUDCD2
NXNL1
PACSIN1
PACSIN2
PAGE2
PAGE5
PAK4
PALM
PCP4
PDE1B
PDLIM2
PEX5
PFKP
PGLS
PGM1
PGM2
PHYHD1
PHYKPL
PIPOX
PRMT7
PROSER2
PYM1
RBKS
RECQL4
RGS14
RHOU
RIF1
RPAP1
RPSA
RTN4
SARS1
SBDS
SERTAD1
SH3BP1
SNCG
STIP1
STUB1
SULT1B1
SULT1C2
SULT4A1
SYAP1
TAGLN
TBCD
TERF1
TMSB10
TMSB4Y
TNKS
TOMM34
TPI1
TPP1
TRIM16
TRIP10
TUBB2A
TUBB4B
TWF2
WIPI2
XAGE2
YWHAE
YWHAG
ZBED2
ZBTB49
ZFP36L1
ZNF32
ZNF790
Entrez ID
9046
25913
HPRD ID
05411
07572
Ensembl ID
ENSG00000147443
ENSG00000128513
Uniprot IDs
B4DKQ6
O60496
A8MTK3
Q5MJ33
Q9NUX5
PDB IDs
2D9W
2DLW
1XJV
3KJO
3KJP
5H65
5UN7
7QXB
7QXS
7S1O
7S1T
7S1U
8SH0
8SH1
8SOJ
8SOK
Enriched GO Terms of Interacting Partners
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Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Protein Tyrosine Kinase Activity
Cell Surface Receptor Signaling Pathway
Non-membrane Spanning Protein Tyrosine Kinase Activity
Immune Response-activating Cell Surface Receptor Signaling Pathway
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Phosphotyrosine Residue Binding
Immune Response-activating Signaling Pathway
Positive Regulation Of Cell Adhesion
Ephrin Receptor Signaling Pathway
Regulation Of Immune Response
Immune Response-regulating Signaling Pathway
Activation Of Immune Response
Regulation Of Cell Adhesion
Fc-gamma Receptor Signaling Pathway
Positive Regulation Of Immune Response
Protein Kinase Activity
Antigen Receptor-mediated Signaling Pathway
Regulation Of Immune System Process
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
T Cell Receptor Signaling Pathway
Kinase Activity
Fc Receptor Signaling Pathway
Positive Regulation Of MAPK Cascade
Fc Receptor Mediated Stimulatory Signaling Pathway
Signal Transduction
Regulation Of MAPK Cascade
Positive Regulation Of Lymphocyte Activation
Ephrin Receptor Binding
Leukocyte Migration
Immune System Process
Negative Regulation Of Immune System Process
Positive Regulation Of Cell Activation
Positive Regulation Of Immune System Process
Positive Regulation Of T Cell Activation
Signaling Receptor Binding
Positive Regulation Of Multicellular Organismal Process
Regulation Of Cellular Component Organization
Positive Regulation Of Leukocyte Cell-cell Adhesion
Negative Regulation Of Defense Response
T Cell Costimulation
Cell Migration
Positive Regulation Of Cell-cell Adhesion
Plasma Membrane
Membrane Raft
Negative Regulation Of Immune Response
Regulation Of Lymphocyte Activation
Regulation Of Cell Migration
Cellular Developmental Process
Cytoplasm
Cytosol
Extracellular Exosome
Cytoskeleton Organization
Actin Filament Organization
Cytoskeleton
Protein Binding
Cadherin Binding
Nicotinamide Nucleotide Metabolic Process
Purine-containing Compound Metabolic Process
Nucleobase-containing Small Molecule Metabolic Process
Supramolecular Fiber Organization
Cellular Response To Heat
Actin Binding
Carbohydrate Catabolic Process
Response To Heat
Pyruvate Metabolic Process
Organelle Organization
Glycolytic Process
Nucleoside Phosphate Metabolic Process
ADP Catabolic Process
Vesicle
Purine Nucleotide Metabolic Process
Identical Protein Binding
Generation Of Precursor Metabolites And Energy
Purine Ribonucleoside Diphosphate Catabolic Process
Small Molecule Metabolic Process
Ribonucleoside Diphosphate Catabolic Process
ADP Metabolic Process
Response To Temperature Stimulus
Nucleoside Diphosphate Catabolic Process
Purine Nucleotide Catabolic Process
Ficolin-1-rich Granule Lumen
Glucose Metabolic Process
Microtubule Cytoskeleton Organization
Nucleoside Phosphate Catabolic Process
Actin Filament-based Process
Actin Cytoskeleton Organization
Monocarboxylic Acid Metabolic Process
Nucleotide Metabolic Process
Negative Regulation Of Cellular Component Organization
Cytoskeletal Protein Binding
Protein Sequestering Activity
Focal Adhesion
Catabolic Process
Monosaccharide Metabolic Process
Actin Monomer Binding
Cellular Response To Raffinose
Nucleotide Catabolic Process
Organic Acid Metabolic Process
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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