DOK2

Description		docking protein 2
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane
	Molecular Function	Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Protein Binding
	Biological Process	Signal Transduction Cell Surface Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Ras Protein Signal Transduction
Pathways		Tie2 Signaling RET signaling
Drugs
Diseases
GWAS		Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Entorhinal cortical thickness ( 21116278) Lymphocyte count ( 32888494) Mean corpuscular volume ( 20139978) Mean platelet volume ( 32888494) Metabolite levels ( 23823483) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Neuropathic pain in type 2 diabetes ( 24974787) Neutrophil percentage of white cells ( 32888494) Pancreatic cancer ( 30206226) Platelet distribution width ( 32888494) Refractive error ( 32231278) Verbal declarative memory ( 25648963)
Interacting Genes		22 interacting genes: ABL1 APPL1 CRK CRKL CSK DOK3 EGFR HCK IL4R INPP5D KIFBP LCK LYN NCK1 POT1 RASA1 RET SRC STAT3 TEK TXK YES1
Entrez ID		9046
HPRD ID		05411
Ensembl ID		ENSG00000147443
Uniprot IDs		B4DKQ6 O60496
PDB IDs		2D9W 2DLW
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Protein Tyrosine Kinase Activity Cell Surface Receptor Signaling Pathway Non-membrane Spanning Protein Tyrosine Kinase Activity Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Phosphotyrosine Residue Binding Immune Response-activating Signaling Pathway Positive Regulation Of Cell Adhesion Ephrin Receptor Signaling Pathway Regulation Of Immune Response Immune Response-regulating Signaling Pathway Activation Of Immune Response Regulation Of Cell Adhesion Fc-gamma Receptor Signaling Pathway Positive Regulation Of Immune Response Protein Kinase Activity Antigen Receptor-mediated Signaling Pathway Regulation Of Immune System Process Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis T Cell Receptor Signaling Pathway Kinase Activity Fc Receptor Signaling Pathway Positive Regulation Of MAPK Cascade Fc Receptor Mediated Stimulatory Signaling Pathway Signal Transduction Regulation Of MAPK Cascade Positive Regulation Of Lymphocyte Activation Ephrin Receptor Binding Leukocyte Migration Immune System Process Negative Regulation Of Immune System Process Positive Regulation Of Cell Activation Positive Regulation Of Immune System Process Positive Regulation Of T Cell Activation Signaling Receptor Binding Positive Regulation Of Multicellular Organismal Process Regulation Of Cellular Component Organization Positive Regulation Of Leukocyte Cell-cell Adhesion Negative Regulation Of Defense Response T Cell Costimulation Cell Migration Positive Regulation Of Cell-cell Adhesion Plasma Membrane Membrane Raft Negative Regulation Of Immune Response Regulation Of Lymphocyte Activation Regulation Of Cell Migration Cellular Developmental Process
Tagcloud ?