DOK2 and RET

Number of citations of the paper that reports this interaction (PMID 11470823)
30

Data Source:
HPRD (two hybrid)

		DOK2	RET
Gene Name		docking protein 2, 56kDa	ret proto-oncogene
Image
Gene Ontology Annotations	Cellular Component	Cytosol	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Endosome Membrane Intracellular Membrane-bounded Organelle Receptor Complex Membrane Raft
	Molecular Function	Receptor Signaling Protein Activity Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Insulin Receptor Binding	Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Receptor Activity Calcium Ion Binding Protein Binding ATP Binding
	Biological Process	Signal Transduction Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Ras Protein Signal Transduction Blood Coagulation Leukocyte Migration	MAPK Cascade Ureteric Bud Development Neural Crest Cell Migration Embryonic Epithelial Tube Formation Protein Phosphorylation Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Neuron Cell-cell Adhesion Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Posterior Midgut Development Positive Regulation Of Neuron Projection Development Positive Regulation Of Neuron Maturation Peptidyl-tyrosine Phosphorylation Regulation Of Cell Adhesion Positive Regulation Of Cell Migration Membrane Protein Proteolysis Positive Regulation Of Cell Adhesion Mediated By Integrin Ureter Maturation Response To Drug Neuron Maturation Positive Regulation Of Cell Size Positive Regulation Of Transcription, DNA-templated Response To Pain Enteric Nervous System Development Regulation Of Axonogenesis Retina Development In Camera-type Eye Innervation Peyer's Patch Morphogenesis Cellular Response To Retinoic Acid Positive Regulation Of Metanephric Glomerulus Development Lymphocyte Migration Into Lymphoid Organs Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		Tie2 Signaling Cell surface interactions at the vascular wall
Drugs			Imatinib
Diseases
GWAS		Entorhinal cortical thickness ( 21116278) Mean corpuscular volume ( 20139978)	Hirschsprung's disease ( 19196962)
Protein-Protein Interactions		14 interactors: ABL1 EGFR HCK IL4R INPP5D KIAA1279 LCK LYN NCK1 POT1 RASA1 RET SRC TEK	36 interactors: AKAP5 CBL CBLB CRK DOK1 DOK2 DOK3 DOK4 DOK5 DOK6 FRS2 GAB1 GDNF GFRA1 GRB10 GRB2 GRB7 IKBKG MAPK1 MAPK14 MAPK3 MAPK8 NOTCH2NL NOTCH3 NRTN PDLIM7 PIK3R1 PLCG1 PRKAR2A PTK2 PTPN11 PTPRF SHC1 SHC3 SRC STAT3
Entrez ID		9046	5979
HPRD ID		05411	01266
Ensembl ID		ENSG00000147443	ENSG00000165731
Uniprot IDs		G3V1Q1 O60496	P07949 Q9BTX6
PDB IDs		2D9W 2DLW	1XPD 2IVS 2IVT 2IVU 2IVV 2X2K 2X2L 2X2M 2X2U
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Peptidyl-tyrosine Phosphorylation Cell Migration Locomotion Regulation Of Immune Response Enzyme Linked Receptor Protein Signaling Pathway Cell Motility Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Cell Adhesion Protein Autophosphorylation Positive Regulation Of Immune Response Regulation Of Apoptotic Process Peptidyl-tyrosine Autophosphorylation Movement Of Cell Or Subcellular Component Leukocyte Migration Regulation Of Cell Death Immune Response-regulating Signaling Pathway Fc Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Immune System Process Positive Regulation Of Immune System Process Positive Regulation Of Cell Adhesion Regulation Of Cell Proliferation Immune System Process Cell Surface Receptor Signaling Pathway Response To Lipid Immune Response Intracellular Signal Transduction Single Organismal Cell-cell Adhesion Regulation Of Cytokine Secretion Positive Regulation Of Cell Activation Antigen Receptor-mediated Signaling Pathway Peptidyl-amino Acid Modification Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Fc-gamma Receptor Signaling Pathway Positive Regulation Of Catalytic Activity Regulation Of Cell-cell Adhesion Regulation Of Lymphocyte Activation Axon Guidance Regulation Of Cellular Amino Acid Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of ERK1 And ERK2 Cascade Cell Morphogenesis Involved In Differentiation Regulation Of Catalytic Activity Cellular Response To Lipid Blood Coagulation	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Neurotrophin Signaling Pathway Cell Surface Receptor Signaling Pathway Signal Transduction Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Signaling Cellular Response To Growth Factor Stimulus Cell Communication Response To Growth Factor Response To Peptide Response To Peptide Hormone Fc Receptor Signaling Pathway Cellular Response To Organonitrogen Compound Positive Regulation Of Signal Transduction Insulin Receptor Signaling Pathway Cellular Response To Insulin Stimulus Cellular Response To Stimulus Fibroblast Growth Factor Receptor Signaling Pathway Intracellular Signal Transduction Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Cellular Response To Hormone Stimulus Immune Response-regulating Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Response To Insulin Response To Organonitrogen Compound Blood Coagulation Hemostasis Activation Of Protein Kinase Activity Cellular Response To Organic Substance Response To Stimulus Innate Immune Response Fc-epsilon Receptor Signaling Pathway Regulation Of Body Fluid Levels Regulation Of Signaling Positive Regulation Of Protein Kinase Activity Wound Healing Regulation Of Signal Transduction Response To Hormone Positive Regulation Of Kinase Activity MAPK Cascade Regulation Of Immune Response Response To Wounding Ras Protein Signal Transduction Positive Regulation Of Transferase Activity
Tagcloud ?		adcy3 angptl2 annotated beadchip bmi boston boys c18orf8 corrected correction cpg epigenomic fdr generational humanmethylation27 illumina infant lends maternal mother offspring plac1 prepregnancy prr16 sapcd2 separately stated wnt16 zcchc10	coimmunoprecipitation crest displays docking enlightening fmtc gdnf grb2 hirschsprung inherited isoform isoforms medullar megacolon neurotrophic neurturin oncogenes owing papillary performing phosphopeptides phosphotyrosines proto ptc2 ptc2y620f ptcs rearrangements separately shc
Tagcloud (Difference) ?		adcy3 angptl2 annotated beadchip bmi boston boys c18orf8 corrected correction cpg epigenomic fdr generational humanmethylation27 illumina infant lends maternal mother offspring plac1 prepregnancy prr16 sapcd2 stated wnt16 zcchc10	coimmunoprecipitation crest displays docking enlightening fmtc gdnf grb2 hirschsprung inherited isoform isoforms medullar megacolon neurotrophic neurturin oncogenes owing papillary performing phosphopeptides phosphotyrosines proto ptc2 ptc2y620f ptcs rearrangements shc
Tagcloud (Intersection) ?		separately