DOK2 and KIFBP

Number of citations of the paper that reports this interaction (PubMedID 16189514)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		DOK2	KIFBP
Description		docking protein 2	kinesin family binding protein
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane	Cytoplasm Mitochondrion Cytoskeleton
	Molecular Function	Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Protein Binding	Protein Binding Kinesin Binding Protein Sequestering Activity
	Biological Process	Signal Transduction Cell Surface Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Ras Protein Signal Transduction	Microtubule Cytoskeleton Organization In Utero Embryonic Development Nervous System Development Transport Along Microtubule Central Nervous System Projection Neuron Axonogenesis Cell Differentiation Mitochondrion Transport Along Microtubule Neuron Projection Maintenance
Pathways		Tie2 Signaling RET signaling
Drugs
Diseases			Goldberg-Shprintzen megacolon syndrome; Goldberg-Shprintzen syndrome (GOSHS) Polymicrogyria; Bilateral frontal polymicrogyria (BFP); Bilateral frontoparietal polymicrogyria (BFPP); Bilateral perisylvian polymicrogyria (BPP); Bilateral parasagittal parieto-occipital polymicrogyria (BPOP); Bilateral generalised polymicrogyria (BGP); Unilateral Polymicrogyria (ULP)
GWAS		Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Entorhinal cortical thickness ( 21116278) Lymphocyte count ( 32888494) Mean corpuscular volume ( 20139978) Mean platelet volume ( 32888494) Metabolite levels ( 23823483) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Neuropathic pain in type 2 diabetes ( 24974787) Neutrophil percentage of white cells ( 32888494) Pancreatic cancer ( 30206226) Platelet distribution width ( 32888494) Refractive error ( 32231278) Verbal declarative memory ( 25648963)
Interacting Genes		22 interacting genes: ABL1 APPL1 CRK CRKL CSK DOK3 EGFR HCK IL4R INPP5D KIFBP LCK LYN NCK1 POT1 RASA1 RET SRC STAT3 TEK TXK YES1	10 interacting genes: ATXN2 CEP76 DOK2 DPEP1 HBP1 PLEKHF1 RGR TERF1 ZNF638 ZNF670
Entrez ID		9046	26128
HPRD ID		05411	13848
Ensembl ID		ENSG00000147443	ENSG00000198954
Uniprot IDs		B4DKQ6 O60496	Q96EK5
PDB IDs		2D9W 2DLW	6ZPG 6ZPH 7RSI 7RSQ 7RYP 7RYQ
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Protein Tyrosine Kinase Activity Cell Surface Receptor Signaling Pathway Non-membrane Spanning Protein Tyrosine Kinase Activity Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Phosphotyrosine Residue Binding Immune Response-activating Signaling Pathway Positive Regulation Of Cell Adhesion Ephrin Receptor Signaling Pathway Regulation Of Immune Response Immune Response-regulating Signaling Pathway Activation Of Immune Response Regulation Of Cell Adhesion Fc-gamma Receptor Signaling Pathway Positive Regulation Of Immune Response Protein Kinase Activity Antigen Receptor-mediated Signaling Pathway Regulation Of Immune System Process Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis T Cell Receptor Signaling Pathway Kinase Activity Fc Receptor Signaling Pathway Positive Regulation Of MAPK Cascade Fc Receptor Mediated Stimulatory Signaling Pathway Signal Transduction Regulation Of MAPK Cascade Positive Regulation Of Lymphocyte Activation Ephrin Receptor Binding Leukocyte Migration Immune System Process Negative Regulation Of Immune System Process Positive Regulation Of Cell Activation Positive Regulation Of Immune System Process Positive Regulation Of T Cell Activation Signaling Receptor Binding Positive Regulation Of Multicellular Organismal Process Regulation Of Cellular Component Organization Positive Regulation Of Leukocyte Cell-cell Adhesion Negative Regulation Of Defense Response T Cell Costimulation Cell Migration Positive Regulation Of Cell-cell Adhesion Plasma Membrane Membrane Raft Negative Regulation Of Immune Response Regulation Of Lymphocyte Activation Regulation Of Cell Migration Cellular Developmental Process	Lactam Catabolic Process Antibiotic Metabolic Process Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Leukotriene D4 Catabolic Process GPI Anchor Binding Beta-lactamase Activity Glutathione Catabolic Process Modified Amino Acid Binding Metallodipeptidase Activity Photoreceptor Activity Regulation Of Establishment Of Protein Localization To Chromosome Nuclear Telomere Cap Complex Regulation Of Establishment Of Protein Localization To Telomere Telomerase Activity Telomere Localization Shelterin Complex Meiotic Telomere Clustering Telomeric D-loop Disassembly Ankyrin Repeat Binding Double-stranded Telomeric DNA Binding Chromosome Localization To Nuclear Envelope Involved In Homologous Chromosome Segregation Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) 7S RNA Binding TRAMP-dependent TRNA Surveillance Pathway TRNA Surveillance Nuclear Polyadenylation-dependent RRNA Catabolic Process U4 SnRNA 3'-end Processing CUT Catabolic Process Poly(A)-dependent SnoRNA 3'-end Processing
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