TFR2 and TF

Number of citations of the paper that reports this interaction (PMID 11027676)
28

Data Source:
HPRD (in vitro, in vivo)

		TFR2	TF
Gene Name		transferrin receptor 2	transferrin
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Integral Component Of Plasma Membrane	Extracellular Region Extracellular Space Early Endosome Late Endosome Coated Pit Basal Plasma Membrane Cell Surface Endosome Membrane Cytoplasmic Membrane-bounded Vesicle Apical Plasma Membrane Endocytic Vesicle Vesicle Secretory Granule Lumen Basal Part Of Cell Perinuclear Region Of Cytoplasm Recycling Endosome Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	Transferrin Receptor Activity	Protein Binding Ferric Iron Binding Ubiquitin Protein Ligase Binding
	Biological Process	Iron Ion Transport Cellular Iron Ion Homeostasis Receptor-mediated Endocytosis	Retina Homeostasis Platelet Degranulation Cellular Iron Ion Homeostasis Blood Coagulation Platelet Activation Transferrin Transport Transmembrane Transport
Pathways			Response to elevated platelet cytosolic Ca2+ Iron uptake and transport Platelet degranulation Transferrin endocytosis and recycling Platelet activation, signaling and aggregation
Drugs			Aluminium
Diseases
GWAS		Hematocrit ( 19862010) Hematological parameters ( 19820697) Iron levels ( 21208937) Mean corpuscular volume ( 19862010) Red blood cell traits ( 23222517)	Alcohol consumption (transferrin glycosylation) ( 21665994) Hepcidin levels ( 21785125) Iron levels ( 21208937) Iron status biomarkers ( 21483845 19084217)
Protein-Protein Interactions		3 interactors: HFE SOCS3 TF	20 interactors: CALR CANX CUBN GRB2 IGF1 IGF2 IGFBP1 IGFBP2 IGFBP3 IGFBP4 IGFBP5 IGFBP6 LAMC3 SH3BP2 SMAD3 TFR2 TFRC TIMELESS TUBB3 VKORC1
Entrez ID		7036	7018
HPRD ID		05282	01811
Ensembl ID		ENSG00000106327	ENSG00000091513
Uniprot IDs		Q9UP52	A0PJA6 J3KN47 P02787 Q06AH7
PDB IDs			1A8E 1A8F 1B3E 1BP5 1BTJ 1D3K 1D4N 1DTG 1FQE 1FQF 1JQF 1N7W 1N7X 1N84 1OQG 1OQH 1RYO 1SUV 2HAU 2HAV 2O7U 2O84 3FGS 3QYT 3S9L 3S9M 3S9N 3SKP 3V83 3V89 3V8X 3VE1 4H0W
Enriched GO Terms of Interacting Partners?		Iron Ion Transport Cellular Iron Ion Homeostasis Iron Ion Homeostasis Transition Metal Ion Homeostasis Cellular Response To Iron Ion Starvation Multicellular Organismal Homeostasis Spongiotrophoblast Differentiation Iron Ion Import Into Cell Cellular Metal Ion Homeostasis Cellular Cation Homeostasis Cellular Ion Homeostasis Metal Ion Homeostasis Branching Involved In Labyrinthine Layer Morphogenesis Cellular Chemical Homeostasis Ion Homeostasis Iron Ion Import Spongiotrophoblast Layer Development Multicellular Organismal Iron Ion Homeostasis Cellular Homeostasis Trophoblast Giant Cell Differentiation Regulation Of Interferon-gamma-mediated Signaling Pathway JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Regulation Of Response To Interferon-gamma Negative Regulation Of JAK-STAT Cascade Labyrinthine Layer Morphogenesis Growth Hormone Receptor Signaling Pathway Response To Stress Cellular Response To Growth Hormone Stimulus Embryonic Placenta Morphogenesis Metal Ion Transport Chemical Homeostasis Regulation Of Immune Response Transferrin Transport Cell Differentiation Involved In Embryonic Placenta Development Placenta Blood Vessel Development Negative Regulation Of Insulin Receptor Signaling Pathway Response To Growth Hormone Regulation Of Type I Interferon-mediated Signaling Pathway Hormone Biosynthetic Process JAK-STAT Cascade Cation Transport Labyrinthine Layer Development Retina Homeostasis Regulation Of Insulin Receptor Signaling Pathway Immune Response Regulation Of Immune System Process Platelet Degranulation Reproductive Process Homeostatic Process Regulation Of Cellular Response To Insulin Stimulus	Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Cell Growth Regulation Of Growth Regulation Of Glucose Metabolic Process Regulation Of Cellular Component Organization Developmental Process Regulation Of Carbohydrate Metabolic Process Type B Pancreatic Cell Proliferation Receptor-mediated Endocytosis Regulation Of Signal Transduction Positive Regulation Of Cell Adhesion Positive Regulation Of Activated T Cell Proliferation Regulation Of Signaling Ossification Regulation Of Activated T Cell Proliferation Positive Regulation Of Signal Transduction Osteoblast Differentiation Regulation Of Phosphorylation Regulation Of Smooth Muscle Cell Migration Wound Healing Regulation Of Cell Adhesion Endocytosis Vesicle-mediated Transport Protein Metabolic Process Regulation Of Phosphorus Metabolic Process Regulation Of Cell Proliferation Response To Wounding Anatomical Structure Development System Development Positive Regulation Of T Cell Activation Exocrine Pancreas Development Positive Regulation Of Homotypic Cell-cell Adhesion Striated Muscle Cell Differentiation Positive Regulation Of Protein Kinase B Signaling Cellular Protein Metabolic Process Tissue Development Positive Regulation Of Cell-cell Adhesion Positive Regulation Of T Cell Proliferation Morphogenesis Of An Epithelium Organ Development Positive Regulation Of Phosphorylation Positive Regulation Of Glycogen Biosynthetic Process Developmental Growth Skeletal System Development Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Smooth Muscle Cell Migration Multicellular Organismal Development Regulation Of T Cell Activation Positive Regulation Of Cell Activation
Tagcloud ?		arrays chemotaxis complement congenital count counts cxcr2 exome frameshift genotyped hbb hematocrit hematological hematopoiesis hemoglobin identifying missense neutropenia pedigree platelet resequencing separate sh2b3 splice traits tubb1 val617phe variants wbc	alleviated bhlh c2 c3h10t1 cip coactivator cofactor cognate cor corepressors coup crosstalk forced helix hinge interacted invitro myod myogenic orphan pluripotential repress repression rip13 silences smrt thatcoup transcriptionally waf
Tagcloud (Difference) ?		arrays chemotaxis complement congenital count counts cxcr2 exome frameshift genotyped hbb hematocrit hematological hematopoiesis hemoglobin identifying missense neutropenia pedigree platelet resequencing separate sh2b3 splice traits tubb1 val617phe variants wbc	alleviated bhlh c2 c3h10t1 cip coactivator cofactor cognate cor corepressors coup crosstalk forced helix hinge interacted invitro myod myogenic orphan pluripotential repress repression rip13 silences smrt thatcoup transcriptionally waf
Tagcloud (Intersection) ?