TFR2 and DCLRE1B

Number of citations of the paper that reports this interaction (PubMedID 18202258)
0

Data Source:
BioGRID (unspecified method, x-ray crystallography, affinity chromatography technology)

		TFR2	DCLRE1B
Description		transferrin receptor 2	DNA cross-link repair 1B
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane External Side Of Plasma Membrane Membrane Cytoplasmic Vesicle HFE-transferrin Receptor Complex	Chromosome, Telomeric Region Nucleus Nucleoplasm Chromosome Cytoplasm Centrosome Cytoskeleton Nuclear Body
	Molecular Function	Transferrin Receptor Activity Protein Binding Co-receptor Binding	Damaged DNA Binding Nuclease Activity Exonuclease Activity Protein Binding 5'-3' Exonuclease Activity Beta-lactamase Activity Hydrolase Activity 5'-3' DNA Exonuclease Activity Protein Homodimerization Activity Protein-containing Complex Binding
	Biological Process	Iron Ion Transport Intracellular Iron Ion Homeostasis Receptor-mediated Endocytosis Response To Iron Ion Transferrin Transport Positive Regulation Of Endocytosis Positive Regulation Of Transcription By RNA Polymerase II Multicellular Organismal-level Iron Ion Homeostasis Cellular Response To Iron Ion Positive Regulation Of Peptide Hormone Secretion Endocytic Iron Import Into Cell Positive Regulation Of Protein Maturation	Telomere Maintenance DNA Repair Double-strand Break Repair Via Nonhomologous End Joining DNA Damage Response Telomere Maintenance Via Telomere Lengthening Telomere Capping Telomeric Loop Formation Protection From Non-homologous End Joining At Telomere Telomeric 3' Overhang Formation Interstrand Cross-link Repair
Pathways		Transferrin endocytosis and recycling	Fanconi Anemia Pathway
Drugs		Ferrous sulfate anhydrous Ferric derisomaltose
Diseases		Hemochromatosis (HFE); Juvenile hemochromatosis (JH)
GWAS		Apolipoprotein B levels ( 32203549) Eosinophil count ( 32888494) Hematocrit ( 19862010 28017375 32888494 27863252) Hematological parameters ( 19820697) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 28017375) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Immature fraction of reticulocytes ( 32888494 27863252) Iron status biomarkers ( 21208937) Iron status biomarkers (iron levels) ( 25352340 33536631) Iron status biomarkers (transferrin saturation) ( 33536631 25352340) Lymphocyte count ( 32888494) Mean corpuscular hemoglobin ( 28017375 32888494 29403010 27863252) Mean corpuscular hemoglobin concentration ( 32888494 29403010 27863252) Mean corpuscular volume ( 19862010 32888494 27863252 28017375) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Platelet count ( 27863252 32888494) Plateletcrit ( 27863252 32888494) Red blood cell count ( 28017375 28453575 29403010 27863252 32888494) Red blood cell traits ( 23222517) Red cell distribution width ( 27863252 28957414 32888494) Reticulocyte fraction of red cells ( 32888494 27863252)	Alopecia areata ( 25608926) Breast cancer ( 23535729 29059683) Coronary artery disease ( 33020668) Crohn's disease ( 23128233 28067908) Parental longevity (combined parental attained age, Martingale residuals) ( 29227965)
Interacting Genes		7 interacting genes: CFTR DCLRE1B HFE OLFM4 SEC22A SOCS3 TF	4 interacting genes: NOXA1 SPAG5 TFR2 TRIM54
Entrez ID		7036	64858
HPRD ID		05282	16785
Ensembl ID		ENSG00000106327	ENSG00000118655
Uniprot IDs		Q9UP52	Q9H816
PDB IDs			3BUA 5AHO 7A1F 7B2X 7B9B
Enriched GO Terms of Interacting Partners?		Multicellular Organismal-level Chemical Homeostasis HFE-transferrin Receptor Complex Cellular Response To Iron Ion Transferrin Receptor Binding Basal Part Of Cell Recycling Endosome Multicellular Organismal-level Iron Ion Homeostasis Response To Iron Ion Perinuclear Region Of Cytoplasm Iron Ion Transport Positive Regulation Of Receptor-mediated Endocytosis Early Endosome Clathrin-coated Endocytic Vesicle Membrane Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Intracellular Iron Ion Homeostasis Negative Regulation Of Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Intracellular Monoatomic Ion Homeostasis Intracellular Monoatomic Cation Homeostasis Positive Regulation Of Anion Channel Activity Negative Regulation Of Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Response To Antipsychotic Drug Telomeric Loop Formation Monoatomic Ion Homeostasis Monoatomic Cation Homeostasis Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Peptide Secretion Multicellular Organismal-level Homeostasis Positive Regulation Of Monoatomic Anion Transport Regulation Of Receptor-mediated Endocytosis Response To Iron Ion Starvation Iron Chaperone Activity Iron Ion Export Across Plasma Membrane Intracellular Chemical Homeostasis Positive Regulation Of Enamel Mineralization Regulation Of Vesicle-mediated Transport Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Beta-lactamase Activity 5'-3' DNA Exonuclease Activity Telomeric 3' Overhang Formation Positive Regulation Of Hormone Secretion Transepithelial Water Transport Positive Regulation Of Endocytosis Cellular Homeostasis Positive Regulation Of Tooth Mineralization Regulation Of Iron Ion Transport Regulation Of Ubiquitin-dependent Protein Catabolic Process Cellular Response To Metal Ion Bicarbonate Transmembrane Transporter Activity	Transferrin Receptor Activity Endocytic Iron Import Into Cell Regulation Of Microtubule Cytoskeleton Organization HFE-transferrin Receptor Complex Cellular Response To Iron Ion Iron Import Into Cell Regulation Of Microtubule-based Process Positive Regulation Of Spindle Assembly Ciliary Rootlet Microtubule Binding Superoxide-generating NADPH Oxidase Activator Activity Microtubule Transferrin Transport Co-receptor Binding Regulation Of Metaphase Plate Congression
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