TFR2 and PRKAR2B

		TFR2	PRKAR2B
Description		transferrin receptor 2	protein kinase cAMP-dependent type II regulatory subunit beta
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane External Side Of Plasma Membrane Membrane Cytoplasmic Vesicle HFE-transferrin Receptor Complex	Cytoplasm Centrosome Cytosol Plasma Membrane CAMP-dependent Protein Kinase Complex Membrane Dendrite Neuronal Cell Body Dendritic Spine Dendritic Shaft Perinuclear Region Of Cytoplasm Extracellular Exosome Ciliary Base Postsynapse Glutamatergic Synapse
	Molecular Function	Transferrin Receptor Activity Protein Binding Co-receptor Binding	Nucleotide Binding CAMP-dependent Protein Kinase Inhibitor Activity Protein Binding CAMP-dependent Protein Kinase Regulator Activity Protein Kinase Binding Protein Domain Specific Binding CAMP Binding Ubiquitin Protein Ligase Binding Protein Kinase A Catalytic Subunit Binding
	Biological Process	Iron Ion Transport Intracellular Iron Ion Homeostasis Receptor-mediated Endocytosis Response To Iron Ion Transferrin Transport Positive Regulation Of Endocytosis Positive Regulation Of Transcription By RNA Polymerase II Multicellular Organismal-level Iron Ion Homeostasis Cellular Response To Iron Ion Positive Regulation Of Peptide Hormone Secretion Endocytic Iron Import Into Cell Positive Regulation Of Protein Maturation	Fatty Acid Metabolic Process Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Learning Intracellular Signal Transduction Modulation Of Chemical Synaptic Transmission Response To Antipsychotic Drug Negative Regulation Of CAMP/PKA Signal Transduction
Pathways		Transferrin endocytosis and recycling	PKA activation PKA activation in glucagon signalling DARPP-32 events Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Vasopressin regulates renal water homeostasis via Aquaporins CREB1 phosphorylation through the activation of Adenylate Cyclase Hedgehog 'off' state Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2 GPER1 signaling ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis Factors involved in megakaryocyte development and platelet production High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
Drugs		Ferrous sulfate anhydrous Ferric derisomaltose	Cyclic adenosine monophosphate
Diseases		Hemochromatosis (HFE); Juvenile hemochromatosis (JH)
GWAS		Apolipoprotein B levels ( 32203549) Eosinophil count ( 32888494) Hematocrit ( 19862010 28017375 32888494 27863252) Hematological parameters ( 19820697) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 28017375) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Immature fraction of reticulocytes ( 32888494 27863252) Iron status biomarkers ( 21208937) Iron status biomarkers (iron levels) ( 25352340 33536631) Iron status biomarkers (transferrin saturation) ( 33536631 25352340) Lymphocyte count ( 32888494) Mean corpuscular hemoglobin ( 28017375 32888494 29403010 27863252) Mean corpuscular hemoglobin concentration ( 32888494 29403010 27863252) Mean corpuscular volume ( 19862010 32888494 27863252 28017375) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Platelet count ( 27863252 32888494) Plateletcrit ( 27863252 32888494) Red blood cell count ( 28017375 28453575 29403010 27863252 32888494) Red blood cell traits ( 23222517) Red cell distribution width ( 27863252 28957414 32888494) Reticulocyte fraction of red cells ( 32888494 27863252)	Adverse response to lamotrigine and phenytoin ( 22379998) Bladder cancer (smoking interaction) ( 24662972) Blood urea nitrogen levels ( 31152163) Femur bone mineral density x serum urate levels interaction ( 34046847) Height ( 28552196) Manganese levels ( 26025379) Response to antipsychotic treatment ( 20195266) Triglyceride levels ( 32203549)
Interacting Genes		7 interacting genes: CFTR DCLRE1B HFE OLFM4 SEC22A SOCS3 TF	17 interacting genes: AKAP1 AKAP10 AKAP11 AKAP14 AKAP19 AKAP4 AKAP5 AKAP9 CFAP91 ECM1 GNAI3 KIF5B LASP1 NBEA OGT PAK1IP1 TAF12
Entrez ID		7036	5577
HPRD ID		05282	01486
Ensembl ID		ENSG00000106327	ENSG00000005249
Uniprot IDs		Q9UP52	B3KY43 P31323
PDB IDs
Enriched GO Terms of Interacting Partners?		Multicellular Organismal-level Chemical Homeostasis HFE-transferrin Receptor Complex Cellular Response To Iron Ion Transferrin Receptor Binding Basal Part Of Cell Recycling Endosome Multicellular Organismal-level Iron Ion Homeostasis Response To Iron Ion Perinuclear Region Of Cytoplasm Iron Ion Transport Positive Regulation Of Receptor-mediated Endocytosis Early Endosome Clathrin-coated Endocytic Vesicle Membrane Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Intracellular Iron Ion Homeostasis Negative Regulation Of Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Intracellular Monoatomic Ion Homeostasis Intracellular Monoatomic Cation Homeostasis Positive Regulation Of Anion Channel Activity Negative Regulation Of Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Response To Antipsychotic Drug Telomeric Loop Formation Monoatomic Ion Homeostasis Monoatomic Cation Homeostasis Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Peptide Secretion Multicellular Organismal-level Homeostasis Positive Regulation Of Monoatomic Anion Transport Regulation Of Receptor-mediated Endocytosis Response To Iron Ion Starvation Iron Chaperone Activity Iron Ion Export Across Plasma Membrane Intracellular Chemical Homeostasis Positive Regulation Of Enamel Mineralization Regulation Of Vesicle-mediated Transport Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Beta-lactamase Activity 5'-3' DNA Exonuclease Activity Telomeric 3' Overhang Formation Positive Regulation Of Hormone Secretion Transepithelial Water Transport Positive Regulation Of Endocytosis Cellular Homeostasis Positive Regulation Of Tooth Mineralization Regulation Of Iron Ion Transport Regulation Of Ubiquitin-dependent Protein Catabolic Process Cellular Response To Metal Ion Bicarbonate Transmembrane Transporter Activity	Protein Kinase A Regulatory Subunit Binding Protein Kinase A Binding Negative Regulation Of Adenylate Cyclase Activity CAMP-dependent Protein Kinase Complex
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