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TFR2 and OLFM4
Number of citations of the paper that reports this interaction (PubMedID
32296183
)
50
Data Source:
BioGRID
(two hybrid)
TFR2
OLFM4
Description
transferrin receptor 2
olfactomedin 4
Image
No pdb structure
No pdb structure
GO Annotations
Cellular Component
Cytoplasm
Plasma Membrane
External Side Of Plasma Membrane
Membrane
Cytoplasmic Vesicle
HFE-transferrin Receptor Complex
Extracellular Region
Extracellular Space
Nucleoplasm
Mitochondrion
Cytosol
Plasma Membrane
Secretory Granule
Protein-containing Complex
Specific Granule Lumen
Specific Granule
Azurophil Granule
Intercellular Bridge
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Tertiary Granule Lumen
Molecular Function
Transferrin Receptor Activity
Protein Binding
Co-receptor Binding
Structural Molecule Activity
Protein Binding
Cadherin Binding
Biological Process
Iron Ion Transport
Intracellular Iron Ion Homeostasis
Receptor-mediated Endocytosis
Response To Iron Ion
Transferrin Transport
Positive Regulation Of Endocytosis
Positive Regulation Of Transcription By RNA Polymerase II
Multicellular Organismal-level Iron Ion Homeostasis
Cellular Response To Iron Ion
Positive Regulation Of Peptide Hormone Secretion
Endocytic Iron Import Into Cell
Positive Regulation Of Protein Maturation
Immune Response
Cell Adhesion
Signal Transduction
Negative Regulation Of Canonical NF-kappaB Signal Transduction
Negative Regulation Of Immune Response
Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Pathways
Transferrin endocytosis and recycling
Neutrophil degranulation
Drugs
Ferrous sulfate anhydrous
Ferric derisomaltose
Diseases
Hemochromatosis (HFE); Juvenile hemochromatosis (JH)
GWAS
Apolipoprotein B levels (
32203549
)
Eosinophil count (
32888494
)
Hematocrit (
19862010
28017375
32888494
27863252
)
Hematological parameters (
19820697
)
Hemoglobin (
32888494
)
Hemoglobin concentration (
27863252
)
Hemoglobin levels (
28017375
)
High light scatter reticulocyte count (
32888494
)
High light scatter reticulocyte percentage of red cells (
27863252
32888494
)
Immature fraction of reticulocytes (
32888494
27863252
)
Iron status biomarkers (
21208937
)
Iron status biomarkers (iron levels) (
25352340
33536631
)
Iron status biomarkers (transferrin saturation) (
33536631
25352340
)
Lymphocyte count (
32888494
)
Mean corpuscular hemoglobin (
28017375
32888494
29403010
27863252
)
Mean corpuscular hemoglobin concentration (
32888494
29403010
27863252
)
Mean corpuscular volume (
19862010
32888494
27863252
28017375
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Platelet count (
27863252
32888494
)
Plateletcrit (
27863252
32888494
)
Red blood cell count (
28017375
28453575
29403010
27863252
32888494
)
Red blood cell traits (
23222517
)
Red cell distribution width (
27863252
28957414
32888494
)
Reticulocyte fraction of red cells (
32888494
27863252
)
Adult body size (
32376654
)
Adventurousness (
30643258
)
Amyotrophic lateral sclerosis (sporadic) (
24529757
)
Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) (
31835028
)
BMI (adjusted for smoking behaviour) (
28443625
)
BMI in non-smokers (
28443625
)
Body mass index (
29381148
24861553
25673413
25953783
28448500
26961502
)
Body mass index (joint analysis main effects and physical activity interaction) (
28448500
)
Body mass index (joint analysis main effects and smoking interaction) (
28443625
)
Body size at age 10 (
32376654
)
Cerebrospinal P-tau181p levels (
28247064
)
Childhood body mass index (
26604143
)
Depression (
29700475
)
Hip circumference (
25673412
)
Immune response to anthrax vaccine (
22658931
)
Intelligence (MTAG) (
29326435
)
Major depressive disorder (
27479909
)
Multisite chronic pain (
33830993
)
Obesity (
23563607
22484627
)
Obesity-related traits (
23251661
)
Waist circumference (
25673412
)
Interacting Genes
7 interacting genes:
CFTR
DCLRE1B
HFE
OLFM4
SEC22A
SOCS3
TF
36 interacting genes:
APP
AQP2
AQP3
BSCL2
C3
CFTR
CLDN7
CLEC17A
CLEC7A
CLSTN3
CLTRN
CREB3L1
EREG
FAM209A
FNDC9
IL11RA
ITM2C
KASH5
KIR2DL3
KIR3DL3
LDLRAD1
LEUTX
LHFPL2
PVR
PVRIG
QPCTL
SAR1A
SLC18A1
SLC22A23
SUSD3
SYNE4
TFR2
TMEM130
TNFSF11
TNFSF14
TSPAN18
Entrez ID
7036
10562
HPRD ID
05282
06580
Ensembl ID
ENSG00000106327
ENSG00000102837
Uniprot IDs
Q9UP52
Q6UX06
PDB IDs
Enriched GO Terms of Interacting Partners
?
Multicellular Organismal-level Chemical Homeostasis
HFE-transferrin Receptor Complex
Cellular Response To Iron Ion
Transferrin Receptor Binding
Basal Part Of Cell
Recycling Endosome
Multicellular Organismal-level Iron Ion Homeostasis
Response To Iron Ion
Perinuclear Region Of Cytoplasm
Iron Ion Transport
Positive Regulation Of Receptor-mediated Endocytosis
Early Endosome
Clathrin-coated Endocytic Vesicle Membrane
Intracellularly ATP-gated Chloride Channel Activity
Positive Regulation Of Voltage-gated Chloride Channel Activity
Sec61 Translocon Complex Binding
Intracellular Iron Ion Homeostasis
Negative Regulation Of Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I
Intracellular Monoatomic Ion Homeostasis
Intracellular Monoatomic Cation Homeostasis
Positive Regulation Of Anion Channel Activity
Negative Regulation Of Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I
Response To Antipsychotic Drug
Telomeric Loop Formation
Monoatomic Ion Homeostasis
Monoatomic Cation Homeostasis
Positive Regulation Of Peptide Hormone Secretion
Positive Regulation Of Peptide Secretion
Multicellular Organismal-level Homeostasis
Positive Regulation Of Monoatomic Anion Transport
Regulation Of Receptor-mediated Endocytosis
Response To Iron Ion Starvation
Iron Chaperone Activity
Iron Ion Export Across Plasma Membrane
Intracellular Chemical Homeostasis
Positive Regulation Of Enamel Mineralization
Regulation Of Vesicle-mediated Transport
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Beta-lactamase Activity
5'-3' DNA Exonuclease Activity
Telomeric 3' Overhang Formation
Positive Regulation Of Hormone Secretion
Transepithelial Water Transport
Positive Regulation Of Endocytosis
Cellular Homeostasis
Positive Regulation Of Tooth Mineralization
Regulation Of Iron Ion Transport
Regulation Of Ubiquitin-dependent Protein Catabolic Process
Cellular Response To Metal Ion
Bicarbonate Transmembrane Transporter Activity
Membrane
Plasma Membrane
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Receptor Ligand Activity
Multicellular Organismal-level Chemical Homeostasis
Water Transport
Multicellular Organismal-level Water Homeostasis
Fluid Transport
Glycerol Transmembrane Transport
Multicellular Organismal-level Homeostasis
Renal Water Transport
Polyol Transmembrane Transport
Meiotic Nuclear Membrane Microtubule Tethering Complex
Regulation Of Extrinsic Apoptotic Signaling Pathway
Response To Yeast
Cell Maturation
Positive Regulation Of Apoptotic Signaling Pathway
Positive Regulation Of Endocytosis
Positive Regulation Of Non-canonical NF-kappaB Signal Transduction
Neuron Remodeling
Water Channel Activity
Organic Hydroxy Compound Transport
Positive Regulation Of Defense Response
Cell Surface
Regulation Of Immune System Process
Renal Water Homeostasis
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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