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IQGAP1 and ACTA1
Number of citations of the paper that reports this interaction (PubMedID
9199170
)
42
Data Source:
HPRD
(in vitro)
IQGAP1
ACTA1
Description
IQ motif containing GTPase activating protein 1
actin alpha 1, skeletal muscle
Image
GO Annotations
Cellular Component
Ruffle
Nucleus
Cytoplasm
Cytosol
Microtubule
Actin Filament
Plasma Membrane
Cell-cell Junction
Focal Adhesion
Cell Cortex
Cytoplasmic Side Of Plasma Membrane
Actin Cytoskeleton
Microtubule Cytoskeleton
Membrane
Basolateral Plasma Membrane
Apical Plasma Membrane
Lateral Plasma Membrane
Axon
Growth Cone
Midbody
Secretory Granule Membrane
Cortical Actin Cytoskeleton
Cell Leading Edge
Slit Diaphragm
Cytoplasmic Ribonucleoprotein Granule
Neuron Projection
Extracellular Exosome
Plasma Membrane Bounded Cell Projection
Ribonucleoprotein Complex
Stress Fiber
Extracellular Space
Cytoplasm
Cytosol
Cytoskeleton
Striated Muscle Thin Filament
Actin Filament
Actin Cytoskeleton
Sarcomere
Lamellipodium
Filopodium
Cell Body
Extracellular Exosome
Blood Microparticle
Molecular Function
MAP-kinase Scaffold Activity
GTPase Inhibitor Activity
GTPase Activator Activity
Calcium Ion Binding
Protein Binding
Calmodulin Binding
Phosphatidylinositol-3,4,5-trisphosphate Binding
Protein Kinase Binding
Protein Phosphatase Binding
Protein Domain Specific Binding
Small GTPase Binding
Protein Serine/threonine Kinase Activator Activity
S100 Protein Binding
Cadherin Binding
Actin Filament Binding
Molecular Adaptor Activity
Nucleotide Binding
Structural Constituent Of Cytoskeleton
Protein Binding
ATP Binding
Hydrolase Activity
Myosin Binding
ADP Binding
Biological Process
MAPK Cascade
Regulation Of Cytokine Production
Signal Transduction
Epidermal Growth Factor Receptor Signaling Pathway
Regulation Of Mitotic Cell Cycle
Fibroblast Growth Factor Receptor Signaling Pathway
Fibroblast Migration
Cell Migration
Negative Regulation Of Dephosphorylation
Cellular Response To Platelet-derived Growth Factor Stimulus
Positive Regulation Of MAPK Cascade
Cellular Response To Fibroblast Growth Factor Stimulus
Platelet-derived Growth Factor Receptor Signaling Pathway
Caveola Assembly
Cellular Response To Calcium Ion
Cellular Response To Epidermal Growth Factor Stimulus
Podocyte Development
Mitotic Actomyosin Contractile Ring Assembly Actin Filament Organization
Neuron Projection Extension
Muscle Contraction
Positive Regulation Of Gene Expression
Skeletal Muscle Thin Filament Assembly
Skeletal Muscle Fiber Development
Mesenchyme Migration
Pathways
Nephrin family interactions
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
RHO GTPases activate IQGAPs
MAP2K and MAPK activation
Neutrophil degranulation
Signaling by moderate kinase activity BRAF mutants
Signaling by high-kinase activity BRAF mutants
Signaling by BRAF and RAF1 fusions
Paradoxical activation of RAF signaling by kinase inactive BRAF
RHOA GTPase cycle
RHOC GTPase cycle
CDC42 GTPase cycle
RAC1 GTPase cycle
RAC2 GTPase cycle
RHOQ GTPase cycle
RHOU GTPase cycle
RHOV GTPase cycle
Signaling downstream of RAS mutants
Signaling by RAF1 mutants
Striated Muscle Contraction
Regulation of CDH1 Function
Formation of the dystrophin-glycoprotein complex (DGC)
Formation of the dystrophin-glycoprotein complex (DGC)
Drugs
Artenimol
Latrunculin A
Sucrose
Ulapualide A
Kabiramide C
Jaspisamide A
Tmr
1-Methylhistidine
Phosphoaminophosphonic Acid-Adenylate Ester
Aplyronine A
Reidispongiolide A
Reidispongiolide C
Sphinxolide B
Latrunculin B
Diseases
Cap myopathy
Congenital fiber type disproportion (CFTD)
Nemaline myopathy
GWAS
Allergic disease (asthma, hay fever and/or eczema) (age of onset) (
32603359
)
Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) (
32603359
)
Allergic disease (asthma, hay fever or eczema) (
29083406
)
Allergic rhinitis (
31361310
)
Basophil count (
32888494
)
Basophil percentage of granulocytes (
27863252
)
Basophil percentage of white cells (
27863252
32888494
)
Chronic postoperative pain (
31903573
)
Glaucoma (primary open-angle) (
33627673
)
Heel bone mineral density (
30598549
)
Heel bone mineral density x serum urate levels interaction (
34046847
)
Lymphocyte count (
27863252
32888494
)
Lymphocyte percentage of white cells (
27863252
32888494
)
Male-pattern baldness (
28196072
)
Multiple sclerosis (
24076602
)
Neutrophil percentage of white cells (
32888494
)
Red cell distribution width (
32888494
)
Rheumatoid arthritis (
32868391
)
White blood cell count (basophil) (
27863252
)
Interacting Genes
45 interacting genes:
ACTA1
AIMP1
AKAP5
APC
CALM1
CDC42
CDH1
CDK1
CDK2
CEBPA
CLIC5
CLIP1
CREBBP
CTNNB1
CYBB
DSCAM
DUX4
EGFR
EZR
GRIA4
ILF2
KDR
LBX1
LCOR
MAPK1
MEI4
MEN1
MEOX2
MYL1
NPHS1
NRIP1
NUMB
OTX2
PDLIM7
PKNOX2
PRKACA
PTPRM
RAC1
S100B
STAU1
SUMO2
TEPSIN
TSG101
UBE2I
VASP
115 interacting genes:
ABL1
ABRA
ACTR10
ACTR1B
ADSS2
AFAP1
AIF1
AJUBA
AMOT
ANXA2
BIN1
CCIN
CCT2
CCT4
CCT5
CFL1
CLIC5
CNN1
CORO2B
COTL1
CTNND1
CTTN
CYFIP1
CYTH1
DHX9
DLG1
DMD
DNASE1
DNMBP
DTNA
DUX4L9
EGFR
EPB41
EPB41L2
EPS8
FGD4
FHOD1
FSCN1
GAS2
GAS7
GC
GSN
HCLS1
HDAC4
HIP1R
HSPB2
HTRA2
IQGAP1
ITGA2
ITPKA
KIF23
KLHL20
LASP1
LINC00624
MACF1
MAP1A
MAPT
MIB2
MINPP1
MYL1
MYLK
MYO10
MYO6
MYO7A
MYO9B
NEXN
NR3C2
NRAP
PAK1
PARVA
PCYT1B
PFDN1
PFN1
PHACTR1
PLD1
PPP1R9B
PRKCA
PRKCD
PRKCE
RAC1
RNF167
RPS6KB1
S100A1
S100A4
SCIN
SMTN
SNCA
SORBS1
SPRR1A
SPTA1
SPTAN1
SPTBN2
TAGLN
TJP1
TLN1
TMSB4X
TMSB4Y
TNNI1
TNNI3
TNNI3K
TP53
TPM2
TPM3
TRIM55
TRIM63
TTN
UBC
USP25
USP6NL
UTRN
VASP
VAV1
VCL
VIL1
XIRP1
Entrez ID
8826
58
HPRD ID
04541
00030
Ensembl ID
ENSG00000140575
ENSG00000143632
Uniprot IDs
A0A0J9YXZ5
P46940
P68133
PDB IDs
1X0H
2RR8
3FAY
3I6X
5L0O
7RNS
7RNU
7RNV
9DUU
9DUV
Enriched GO Terms of Interacting Partners
?
Intracellular Signaling Cassette
Cadherin Binding
Focal Adhesion
Positive Regulation Of Protein Localization
Developmental Process
Lamellipodium
Cell-cell Junction Organization
Positive Regulation Of Cellular Component Organization
Modulation Of Chemical Synaptic Transmission
Positive Regulation Of Organelle Organization
Cellular Developmental Process
Centrosome
Intracellular Signal Transduction
Glutamatergic Synapse
Cell Development
Neuron Fate Determination
Cell Projection
Cytoskeleton
Regulation Of Cell Population Proliferation
Anatomical Structure Morphogenesis
Regulation Of Protein Localization
Cell Junction Organization
Positive Regulation Of Metabolic Process
Regulation Of Gene Expression
Regulation Of Protein Catabolic Process
Regulation Of Transcription By RNA Polymerase II
Cell Periphery
Anatomical Structure Formation Involved In Morphogenesis
Positive Regulation Of Cellular Component Biogenesis
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Organelle Organization
Regulation Of Cellular Localization
Actin Cytoskeleton
Adherens Junction
Cytoplasm
Adherens Junction Organization
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of DNA-templated Transcription
Regulation Of Phosphorylation
Regulation Of Cell Cycle
Regulation Of RNA Biosynthetic Process
Regulation Of Locomotion
Regulation Of Synaptic Plasticity
Regulation Of Phosphorus Metabolic Process
Positive Regulation Of Biosynthetic Process
Regulation Of Developmental Process
Cytosol
Cyclin-dependent Protein Kinase Activity
Regulation Of Protein Metabolic Process
Positive Regulation Of Locomotion
Actin Binding
Actin Filament Binding
Cytoskeleton
Actin Cytoskeleton
Actin Filament-based Process
Cytoplasm
Actin Filament Organization
Regulation Of Supramolecular Fiber Organization
Regulation Of Actin Filament Organization
Actin Cytoskeleton Organization
Supramolecular Fiber Organization
Regulation Of Actin Polymerization Or Depolymerization
Regulation Of Actin Cytoskeleton Organization
Regulation Of Actin Filament Polymerization
Regulation Of Actin Filament Length
Regulation Of Cytoskeleton Organization
Regulation Of Actin Filament-based Process
Cytosol
Regulation Of Cellular Component Size
Regulation Of Protein-containing Complex Assembly
Cell Cortex
Cytoskeleton Organization
Regulation Of Organelle Organization
Regulation Of Cellular Component Organization
Focal Adhesion
Positive Regulation Of Supramolecular Fiber Organization
Positive Regulation Of Organelle Organization
Positive Regulation Of Cytoskeleton Organization
Negative Regulation Of Supramolecular Fiber Organization
Lamellipodium
Ruffle
Actin Filament
Negative Regulation Of Cytoskeleton Organization
Negative Regulation Of Actin Filament Polymerization
Positive Regulation Of Cellular Component Organization
Positive Regulation Of Protein Localization
Cortical Actin Cytoskeleton
Positive Regulation Of Cellular Component Biogenesis
Actin Polymerization Or Depolymerization
Regulation Of Biological Quality
Anchoring Junction
Organelle Organization
Ruffle Membrane
Positive Regulation Of Protein-containing Complex Assembly
Cell Projection
Filopodium
Regulation Of Cell Shape
Muscle System Process
Negative Regulation Of Actin Filament Depolymerization
Regulation Of Protein Localization
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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