IQGAP1 and NRIP1

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		IQGAP1	NRIP1
Description		IQ motif containing GTPase activating protein 1	nuclear receptor interacting protein 1
Image
GO Annotations	Cellular Component	Ruffle Nucleus Cytoplasm Cytosol Microtubule Actin Filament Plasma Membrane Cell-cell Junction Focal Adhesion Cell Cortex Cytoplasmic Side Of Plasma Membrane Actin Cytoskeleton Microtubule Cytoskeleton Membrane Basolateral Plasma Membrane Apical Plasma Membrane Lateral Plasma Membrane Axon Growth Cone Midbody Secretory Granule Membrane Cortical Actin Cytoskeleton Cell Leading Edge Slit Diaphragm Cytoplasmic Ribonucleoprotein Granule Neuron Projection Extracellular Exosome Plasma Membrane Bounded Cell Projection Ribonucleoprotein Complex	Histone Deacetylase Complex Chromatin Fibrillar Center Nucleus Nucleoplasm Nucleolus Cytosol Nuclear Speck
	Molecular Function	MAP-kinase Scaffold Activity GTPase Inhibitor Activity GTPase Activator Activity Calcium Ion Binding Protein Binding Calmodulin Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Protein Kinase Binding Protein Phosphatase Binding Protein Domain Specific Binding Small GTPase Binding Protein Serine/threonine Kinase Activator Activity S100 Protein Binding Cadherin Binding Actin Filament Binding Molecular Adaptor Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Transcription Coregulator Activity Transcription Coactivator Activity Transcription Corepressor Activity Signaling Receptor Binding Protein Binding Nuclear Receptor Binding Nuclear Estrogen Receptor Binding Nuclear Glucocorticoid Receptor Binding Histone Deacetylase Binding Nuclear Retinoic Acid Receptor Binding Nuclear Retinoid X Receptor Binding
	Biological Process	MAPK Cascade Regulation Of Cytokine Production Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Mitotic Cell Cycle Fibroblast Growth Factor Receptor Signaling Pathway Fibroblast Migration Cell Migration Negative Regulation Of Dephosphorylation Cellular Response To Platelet-derived Growth Factor Stimulus Positive Regulation Of MAPK Cascade Cellular Response To Fibroblast Growth Factor Stimulus Platelet-derived Growth Factor Receptor Signaling Pathway Caveola Assembly Cellular Response To Calcium Ion Cellular Response To Epidermal Growth Factor Stimulus Podocyte Development Mitotic Actomyosin Contractile Ring Assembly Actin Filament Organization Neuron Projection Extension	Negative Regulation Of Transcription By RNA Polymerase II Ovarian Follicle Rupture Regulation Of Transcription By RNA Polymerase II Circadian Rhythm Lipid Storage Ovulation Circadian Regulation Of Gene Expression Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process Cellular Response To Estradiol Stimulus
Pathways		Nephrin family interactions Glucagon-like Peptide-1 (GLP1) regulates insulin secretion RHO GTPases activate IQGAPs MAP2K and MAPK activation Neutrophil degranulation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF RHOA GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOQ GTPase cycle RHOU GTPase cycle RHOV GTPase cycle Signaling downstream of RAS mutants Signaling by RAF1 mutants	SUMOylation of transcription cofactors Estrogen-dependent gene expression NR1H2 & NR1H3 regulate gene expression linked to lipogenesis NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis Heme signaling Expression of BMAL (ARNTL), CLOCK, and NPAS2 RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression
Drugs		Artenimol	4-HYDROXY-N'-(4-ISOPROPYLBENZYL)BENZOHYDRAZIDE
Diseases
GWAS		Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 31361310) Basophil count ( 32888494) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 27863252 32888494) Chronic postoperative pain ( 31903573) Glaucoma (primary open-angle) ( 33627673) Heel bone mineral density ( 30598549) Heel bone mineral density x serum urate levels interaction ( 34046847) Lymphocyte count ( 27863252 32888494) Lymphocyte percentage of white cells ( 27863252 32888494) Male-pattern baldness ( 28196072) Multiple sclerosis ( 24076602) Neutrophil percentage of white cells ( 32888494) Red cell distribution width ( 32888494) Rheumatoid arthritis ( 32868391) White blood cell count (basophil) ( 27863252)	Alcohol dependence ( 26365420) Birth weight ( 27680694 31043758) Blood urea nitrogen levels ( 31152163) Breast cancer ( 23535729 29059683) Chronic kidney disease ( 31152163) Cognitive performance ( 19734545) Crohn's disease ( 25489960) Depression in smokers ( 30219690) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Estimated glomerular filtration rate ( 31152163 31451708 30604766 31015462) Estimated glomerular filtration rate in non-diabetics ( 31451708) Gastroesophageal reflux disease ( 31527586) HDL cholesterol levels ( 32203549) Hematocrit ( 32888494) Hemoglobin ( 32888494) Lymphocyte count ( 32888494) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (diuretics) ( 31015401) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Platelet count ( 32888494) Platelet distribution width ( 27863252 32888494) Plateletcrit ( 32888494) Pulse pressure ( 27841878) Red blood cell count ( 32888494) Refractive error ( 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Systolic blood pressure ( 27841878) White blood cell count ( 32888494)
Interacting Genes		45 interacting genes: ACTA1 AIMP1 AKAP5 APC CALM1 CDC42 CDH1 CDK1 CDK2 CEBPA CLIC5 CLIP1 CREBBP CTNNB1 CYBB DSCAM DUX4 EGFR EZR GRIA4 ILF2 KDR LBX1 LCOR MAPK1 MEI4 MEN1 MEOX2 MYL1 NPHS1 NRIP1 NUMB OTX2 PDLIM7 PKNOX2 PRKACA PTPRM RAC1 S100B STAU1 SUMO2 TEPSIN TSG101 UBE2I VASP	124 interacting genes: ACBD3 ACTN2 AGR2 AHR AKAP6 ANKRD24 APP AR ARPC3 BAIAP2 BRCA1 CCDC85B CDK8 CEP70 CIB1 CLPB COG4 CREBZF CRNKL1 CTBP1 CTBP2 DNMT1 DNMT3A DNMT3B DST DYNC2I1 E2F1 ERC2 ESR1 ESR2 ESRRA ESRRB ESRRG EXOC7 FEZ1 FMNL2 GPRASP3 GPSM2 HDAC1 HDAC2 HDAC3 HDAC5 HDAC9 HECTD1 HNF4A HSPA5 HUWE1 IMMT IPO5 IQGAP1 JAKMIP3 JUN KALRN KANK2 KAT2B KDM5B KIF3A KIF5A KLHL7 KPNA3 KPNA4 LDOC1 LRRCC1 MACF1 MAP3K7 MAPK8IP3 MLLT3 MTMR10 NCKAP5 NR0B1 NR1H2 NR1H3 NR2C1 NR3C1 NR5A1 NR5A2 NSUN2 OAZ1 ODF2 PIAS1 PIAS3 PKNOX1 PKNOX2 PLAAT3 PLK2 PPARA PPARD PPARG PRMT1 PSMD1 RABEP1 RARA RARB RORB RXRA RXRB RXRG SCG2 SCG3 SESTD1 SF3B1 SHTN1 SNX1 SPTB SPTBN1 TERF1 TEX11 THRA THRB TMEM131 TNFRSF14 TRAF2 TRIM8 TRIM9 TRIP12 TTLL5 TULP3 TXLNG TXNDC11 UBE2I VDR YWHAH ZNF365 ZNF821
Entrez ID		8826	8204
HPRD ID		04541	03927
Ensembl ID		ENSG00000140575	ENSG00000180530
Uniprot IDs		A0A0J9YXZ5 P46940	A8K171 P48552
PDB IDs		1X0H 2RR8 3FAY 3I6X 5L0O	2GPO 2GPP 4S14 4S15 5NTI 5NTN 5NTW 5NU1 6FZU 6G05 6G07 9CWN
Enriched GO Terms of Interacting Partners?		Intracellular Signaling Cassette Cadherin Binding Focal Adhesion Positive Regulation Of Protein Localization Developmental Process Lamellipodium Cell-cell Junction Organization Positive Regulation Of Cellular Component Organization Modulation Of Chemical Synaptic Transmission Positive Regulation Of Organelle Organization Cellular Developmental Process Centrosome Intracellular Signal Transduction Glutamatergic Synapse Cell Development Neuron Fate Determination Cell Projection Cytoskeleton Regulation Of Cell Population Proliferation Anatomical Structure Morphogenesis Regulation Of Protein Localization Cell Junction Organization Positive Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of Protein Catabolic Process Regulation Of Transcription By RNA Polymerase II Cell Periphery Anatomical Structure Formation Involved In Morphogenesis Positive Regulation Of Cellular Component Biogenesis Regulation Of Macromolecule Biosynthetic Process Regulation Of Organelle Organization Regulation Of Cellular Localization Actin Cytoskeleton Adherens Junction Cytoplasm Adherens Junction Organization Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of Phosphorylation Regulation Of Cell Cycle Regulation Of RNA Biosynthetic Process Regulation Of Locomotion Regulation Of Synaptic Plasticity Regulation Of Phosphorus Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Developmental Process Cytosol Cyclin-dependent Protein Kinase Activity Regulation Of Protein Metabolic Process Positive Regulation Of Locomotion	Nuclear Receptor Activity Intracellular Receptor Signaling Pathway Nuclear Receptor-mediated Signaling Pathway Hormone-mediated Signaling Pathway Nuclear Steroid Receptor Activity Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Negative Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Negative Regulation Of RNA Metabolic Process Sequence-specific DNA Binding Retinoic Acid Receptor Signaling Pathway Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process RNA Polymerase II Transcription Regulator Complex DNA-binding Transcription Factor Activity Intracellular Signal Transduction Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Biosynthetic Process Positive Regulation Of Metabolic Process Nucleoplasm Estrogen Response Element Binding Transcription Coregulator Binding Sequence-specific Double-stranded DNA Binding Enzyme Binding Regulation Of Primary Metabolic Process Regulation Of Developmental Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Cytoplasm Nucleus Negative Regulation Of Biosynthetic Process DNA Binding Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Metabolic Process
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