IQGAP1

Gene Name		IQ motif containing GTPase activating protein 1
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Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Microtubule Actin Filament Plasma Membrane Focal Adhesion Actin Cytoskeleton Microtubule Cytoskeleton Lateral Plasma Membrane Cell Junction Axon Growth Cone Midbody Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Cell Leading Edge Slit Diaphragm Cytoplasmic Ribonucleoprotein Granule Neuron Projection Extracellular Vesicular Exosome
	Molecular Function	GTPase Inhibitor Activity GTPase Activator Activity Ras GTPase Activator Activity Calcium Ion Binding Protein Binding Calmodulin Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Protein Kinase Binding Protein Phosphatase Binding Protein Complex Binding Protein Serine/threonine Kinase Activator Activity Rac GTPase Binding
	Biological Process	Regulation Of Cytokine Production Energy Reserve Metabolic Process Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Ras GTPase Activity Negative Regulation Of Dephosphorylation Cellular Response To Platelet-derived Growth Factor Stimulus Negative Regulation Of Catalytic Activity Positive Regulation Of GTPase Activity Small Molecule Metabolic Process Positive Regulation Of Protein Kinase Activity Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of Insulin Secretion Cellular Response To Calcium Ion Cellular Response To Epidermal Growth Factor Stimulus Positive Regulation Of Protein Serine/threonine Kinase Activity Glomerular Visceral Epithelial Cell Development Neuron Projection Extension
Pathways		Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Integration of energy metabolism Regulation of insulin secretion Nephrin interactions
Drugs
Diseases
GWAS
Protein-protein Interactions		24 interactors: ACTA1 AIMP1 AKAP5 APC CALM1 CDC42 CDH1 CLIC5 CLIP1 CTNNB1 CYBB EZR GRIA4 KDR MAPK1 MEN1 NPHS1 PDLIM7 PRKACA RAC1 S100B STAU1 TSG101 YWHAQ
Entrez ID		8826
HPRD ID		04541
Ensembl ID		ENSG00000140575
Uniprot IDs		P46940
PDB IDs		1X0H 2RR8 3FAY 3I6X
Enriched GO Terms of Interacting Partners?		Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Cellular Component Organization Epithelium Development Cell Development Regulation Of Organelle Organization Positive Regulation Of Cellular Component Biogenesis Anatomical Structure Morphogenesis Multicellular Organismal Development Epithelial Cell Development System Development Epithelial Cell Differentiation Tissue Development Cell Differentiation Developmental Process Positive Regulation Of Signal Transduction Organ Development Anatomical Structure Development Cell Morphogenesis Involved In Differentiation Regulation Of Cellular Localization Cell-cell Junction Organization Nervous System Development Regulation Of Cell Proliferation Positive Regulation Of Organelle Organization Regulation Of Cell Differentiation Positive Regulation Of Protein Modification Process Positive Regulation Of Protein Metabolic Process Regulation Of Osteoblast Differentiation Epidermis Development Apoptotic Process Epidermal Cell Differentiation Organelle Organization Immune System Process Regulation Of Epithelial Cell Proliferation Programmed Cell Death Regulation Of Cytoskeleton Organization Cell Death Death Cell Morphogenesis Response To External Stimulus Regulation Of Signal Transduction Regulation Of Apoptotic Process Regulation Of Phosphorus Metabolic Process Positive Regulation Of Protein Complex Assembly Positive Regulation Of Cellular Protein Metabolic Process Movement Of Cell Or Subcellular Component Positive Regulation Of Intracellular Signal Transduction Innate Immune Response Regulation Of Protein Complex Assembly Neuron Differentiation Protein Localization
Tagcloud ?		activating binds canonical clinicopathological coexpression correlating cytoplamic cytoplasm dishevelled dvl embryos expressions growths gtpase localization lymph membranous metastase metastases modulator nodal nsclc nucleus poor prognosis resection wnt xenopus