IQGAP1 and NPHS1

Number of citations of the paper that reports this interaction (PubMedID 25652011)
34

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, in vivo)

		IQGAP1	NPHS1
Description		IQ motif containing GTPase activating protein 1	NPHS1 adhesion molecule, nephrin
Image
GO Annotations	Cellular Component	Ruffle Nucleus Cytoplasm Cytosol Microtubule Actin Filament Plasma Membrane Cell-cell Junction Focal Adhesion Cell Cortex Cytoplasmic Side Of Plasma Membrane Actin Cytoskeleton Microtubule Cytoskeleton Membrane Basolateral Plasma Membrane Apical Plasma Membrane Lateral Plasma Membrane Axon Growth Cone Midbody Secretory Granule Membrane Cortical Actin Cytoskeleton Cell Leading Edge Slit Diaphragm Cytoplasmic Ribonucleoprotein Granule Neuron Projection Extracellular Exosome Plasma Membrane Bounded Cell Projection Ribonucleoprotein Complex	Plasma Membrane Cell-cell Junction Focal Adhesion Membrane Slit Diaphragm Cell Projection Extracellular Exosome Cell Periphery
	Molecular Function	MAP-kinase Scaffold Activity GTPase Inhibitor Activity GTPase Activator Activity Calcium Ion Binding Protein Binding Calmodulin Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Protein Kinase Binding Protein Phosphatase Binding Protein Domain Specific Binding Small GTPase Binding Protein Serine/threonine Kinase Activator Activity S100 Protein Binding Cadherin Binding Actin Filament Binding Molecular Adaptor Activity	Protein Binding Myosin Binding Cell Adhesion Molecule Binding
	Biological Process	MAPK Cascade Regulation Of Cytokine Production Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Mitotic Cell Cycle Fibroblast Growth Factor Receptor Signaling Pathway Fibroblast Migration Cell Migration Negative Regulation Of Dephosphorylation Cellular Response To Platelet-derived Growth Factor Stimulus Positive Regulation Of MAPK Cascade Cellular Response To Fibroblast Growth Factor Stimulus Platelet-derived Growth Factor Receptor Signaling Pathway Caveola Assembly Cellular Response To Calcium Ion Cellular Response To Epidermal Growth Factor Stimulus Podocyte Development Mitotic Actomyosin Contractile Ring Assembly Actin Filament Organization Neuron Projection Extension	MAPK Cascade Cell Adhesion JNK Cascade Muscle Organ Development Skeletal Muscle Tissue Development Myoblast Fusion Gene Expression Positive Regulation Of Actin Filament Polymerization Glomerular Basement Membrane Development Protein Localization To Synapse Slit Diaphragm Assembly Podocyte Development Cell-cell Adhesion
Pathways		Nephrin family interactions Glucagon-like Peptide-1 (GLP1) regulates insulin secretion RHO GTPases activate IQGAPs MAP2K and MAPK activation Neutrophil degranulation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF RHOA GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOQ GTPase cycle RHOU GTPase cycle RHOV GTPase cycle Signaling downstream of RAS mutants Signaling by RAF1 mutants	Nephrin family interactions Nephrin family interactions
Drugs		Artenimol
Diseases			Nephrotic syndrome and focal segmental glomerulosclerosis
GWAS		Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 31361310) Basophil count ( 32888494) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 27863252 32888494) Chronic postoperative pain ( 31903573) Glaucoma (primary open-angle) ( 33627673) Heel bone mineral density ( 30598549) Heel bone mineral density x serum urate levels interaction ( 34046847) Lymphocyte count ( 27863252 32888494) Lymphocyte percentage of white cells ( 27863252 32888494) Male-pattern baldness ( 28196072) Multiple sclerosis ( 24076602) Neutrophil percentage of white cells ( 32888494) Red cell distribution width ( 32888494) Rheumatoid arthritis ( 32868391) White blood cell count (basophil) ( 27863252)
Interacting Genes		45 interacting genes: ACTA1 AIMP1 AKAP5 APC CALM1 CDC42 CDH1 CDK1 CDK2 CEBPA CLIC5 CLIP1 CREBBP CTNNB1 CYBB DSCAM DUX4 EGFR EZR GRIA4 ILF2 KDR LBX1 LCOR MAPK1 MEI4 MEN1 MEOX2 MYL1 NPHS1 NRIP1 NUMB OTX2 PDLIM7 PKNOX2 PRKACA PTPRM RAC1 S100B STAU1 SUMO2 TEPSIN TSG101 UBE2I VASP	11 interacting genes: CASK CD2AP FYN IQGAP1 KIRREL1 LYN NCK1 NCK2 NPHS2 SRC YES1
Entrez ID		8826	4868
HPRD ID		04541	04094
Ensembl ID		ENSG00000140575	ENSG00000161270
Uniprot IDs		A0A0J9YXZ5 P46940	O60500
PDB IDs		1X0H 2RR8 3FAY 3I6X 5L0O	4ZRT
Enriched GO Terms of Interacting Partners?		Intracellular Signaling Cassette Cadherin Binding Focal Adhesion Positive Regulation Of Protein Localization Developmental Process Lamellipodium Cell-cell Junction Organization Positive Regulation Of Cellular Component Organization Modulation Of Chemical Synaptic Transmission Positive Regulation Of Organelle Organization Cellular Developmental Process Centrosome Intracellular Signal Transduction Glutamatergic Synapse Cell Development Neuron Fate Determination Cell Projection Cytoskeleton Regulation Of Cell Population Proliferation Anatomical Structure Morphogenesis Regulation Of Protein Localization Cell Junction Organization Positive Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of Protein Catabolic Process Regulation Of Transcription By RNA Polymerase II Cell Periphery Anatomical Structure Formation Involved In Morphogenesis Positive Regulation Of Cellular Component Biogenesis Regulation Of Macromolecule Biosynthetic Process Regulation Of Organelle Organization Regulation Of Cellular Localization Actin Cytoskeleton Adherens Junction Cytoplasm Adherens Junction Organization Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of Phosphorylation Regulation Of Cell Cycle Regulation Of RNA Biosynthetic Process Regulation Of Locomotion Regulation Of Synaptic Plasticity Regulation Of Phosphorus Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Developmental Process Cytosol Cyclin-dependent Protein Kinase Activity Regulation Of Protein Metabolic Process Positive Regulation Of Locomotion	Ephrin Receptor Signaling Pathway Cell-cell Junction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Platelet-derived Growth Factor Stimulus Enzyme-linked Receptor Protein Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Response To Platelet-derived Growth Factor Actin Filament Ephrin Receptor Binding Negative Regulation Of Inflammatory Response To Antigenic Stimulus Immune Response-activating Cell Surface Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Positive Regulation Of T Cell Activation Cell Migration Positive Regulation Of Leukocyte Cell-cell Adhesion Immune Response-regulating Cell Surface Receptor Signaling Pathway Non-membrane Spanning Protein Tyrosine Kinase Activity Signal Complex Assembly Slit Diaphragm T Cell Costimulation Positive Regulation Of Cell-cell Adhesion Positive Regulation Of Lymphocyte Activation Cell Motility Immune Response-activating Signaling Pathway Fc Receptor Signaling Pathway Regulation Of Leukocyte Cell-cell Adhesion Regulation Of T Cell Activation Positive Regulation Of Cell Activation Signaling Receptor Binding Immune Response-regulating Signaling Pathway Scaffold Protein Binding Activation Of Immune Response Response To Transforming Growth Factor Beta Regulation Of Cell Adhesion Stimulatory C-type Lectin Receptor Signaling Pathway Positive Regulation Of Cell Adhesion Cellular Response To Lectin Regulation Of Cell-cell Adhesion Regulation Of Lymphocyte Activation Cell Periphery Actin Filament Organization Positive Regulation Of Immune System Process Response To Growth Factor Protein Tyrosine Kinase Activity Regulation Of Cell Activation Transmembrane Transporter Binding Positive Regulation Of Immune Response Antigen Receptor-mediated Signaling Pathway Regulation Of Translation Initiation In Response To Endoplasmic Reticulum Stress
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