IQGAP1 and S100B

Number of citations of the paper that reports this interaction (PMID 12377780)
17

Data Source:
HPRD (in vivo, in vitro)

		IQGAP1	S100B
Gene Name		IQ motif containing GTPase activating protein 1	S100 calcium binding protein B
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Microtubule Actin Filament Plasma Membrane Focal Adhesion Actin Cytoskeleton Microtubule Cytoskeleton Lateral Plasma Membrane Cell Junction Axon Growth Cone Midbody Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Cell Leading Edge Slit Diaphragm Cytoplasmic Ribonucleoprotein Granule Neuron Projection Extracellular Vesicular Exosome	Ruffle Extracellular Region Extracellular Space Nucleus Cytoplasm Neuronal Cell Body Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm
	Molecular Function	GTPase Inhibitor Activity GTPase Activator Activity Ras GTPase Activator Activity Calcium Ion Binding Protein Binding Calmodulin Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Protein Kinase Binding Protein Phosphatase Binding Protein Complex Binding Protein Serine/threonine Kinase Activator Activity Rac GTPase Binding	Calcium Ion Binding Protein Binding Zinc Ion Binding Identical Protein Binding Protein Homodimerization Activity S100 Protein Binding Tau Protein Binding Calcium-dependent Protein Binding RAGE Receptor Binding
	Biological Process	Regulation Of Cytokine Production Energy Reserve Metabolic Process Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Ras GTPase Activity Negative Regulation Of Dephosphorylation Cellular Response To Platelet-derived Growth Factor Stimulus Negative Regulation Of Catalytic Activity Positive Regulation Of GTPase Activity Small Molecule Metabolic Process Positive Regulation Of Protein Kinase Activity Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of Insulin Secretion Cellular Response To Calcium Ion Cellular Response To Epidermal Growth Factor Stimulus Positive Regulation Of Protein Serine/threonine Kinase Activity Glomerular Visceral Epithelial Cell Development Neuron Projection Extension	Axonogenesis Central Nervous System Development Learning Or Memory Memory Cell Proliferation Positive Regulation Of Cell Proliferation Regulation Of Cell Shape Positive Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Regulation Of Neuronal Synaptic Plasticity Astrocyte Differentiation Response To Glucocorticoid Response To Methylmercury Long-term Synaptic Potentiation Cellular Response To Hypoxia Negative Regulation Of Skeletal Muscle Cell Differentiation
Pathways		Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Integration of energy metabolism Regulation of insulin secretion Nephrin interactions	Toll Like Receptor 7/8 (TLR7/8) Cascade RIP-mediated NFkB activation via ZBP1 Toll Like Receptor TLR6:TLR2 Cascade DEx/H-box helicases activate type I IFN and inflammatory cytokines production Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade ZBP1(DAI) mediated induction of type I IFNs MyD88 dependent cascade initiated on endosome MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Toll Like Receptor 9 (TLR9) Cascade Advanced glycosylation endproduct receptor signaling Innate Immune System TRIF-mediated TLR3/TLR4 signaling Cytosolic sensors of pathogen-associated DNA Signaling by ERBB4 MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Toll-Like Receptors Cascades Nuclear signaling by ERBB4 Toll Like Receptor 10 (TLR10) Cascade Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade TRAF6 mediated NF-kB activation TAK1 activates NFkB by phosphorylation and activation of IKKs complex
Drugs			Olopatadine Calcium N-Formylmethionine (Z)-2-[2-(4-methylpiperazin-1-yl)benzyl]diazenecarbothioamide 2-[(5-hex-1-yn-1-ylfuran-2-yl)carbonyl]-N-methylhydrazinecarbothioamide
Diseases
GWAS			Lymphocyte counts ( 22286170)
Protein-Protein Interactions		24 interactors: ACTA1 AIMP1 AKAP5 APC CALM1 CDC42 CDH1 CLIC5 CLIP1 CTNNB1 CYBB EZR GRIA4 KDR MAPK1 MEN1 NPHS1 PDLIM7 PRKACA RAC1 S100B STAU1 TSG101 YWHAQ	27 interactors: AGER AHNAK ANXA6 CACYBP CALM1 CAPZA1 DES GFAP GUCY2D IMPA1 IQGAP1 MAPT MDM2 NDRG1 PGM1 S100A1 S100A11 S100A2 S100A4 S100A6 S100P SPG21 STK38 SUGT1 TNIP1 TP53 VAV1
Entrez ID		8826	6285
HPRD ID		04541	01505
Ensembl ID		ENSG00000140575
Uniprot IDs		P46940	P04271
PDB IDs		1X0H 2RR8 3FAY 3I6X	1MQ1 1UWO 2H61 2PRU 3CZT 3D0Y 3D10 3HCM
Enriched GO Terms of Interacting Partners?		Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Cellular Component Organization Epithelium Development Cell Development Regulation Of Organelle Organization Positive Regulation Of Cellular Component Biogenesis Anatomical Structure Morphogenesis Multicellular Organismal Development Epithelial Cell Development System Development Epithelial Cell Differentiation Tissue Development Cell Differentiation Developmental Process Positive Regulation Of Signal Transduction Organ Development Anatomical Structure Development Cell Morphogenesis Involved In Differentiation Regulation Of Cellular Localization Cell-cell Junction Organization Nervous System Development Regulation Of Cell Proliferation Positive Regulation Of Organelle Organization Regulation Of Cell Differentiation Positive Regulation Of Protein Modification Process Positive Regulation Of Protein Metabolic Process Regulation Of Osteoblast Differentiation Epidermis Development Apoptotic Process Epidermal Cell Differentiation Organelle Organization Immune System Process Regulation Of Epithelial Cell Proliferation Programmed Cell Death Regulation Of Cytoskeleton Organization Cell Death Death Cell Morphogenesis Response To External Stimulus Regulation Of Signal Transduction Regulation Of Apoptotic Process Regulation Of Phosphorus Metabolic Process Positive Regulation Of Protein Complex Assembly Positive Regulation Of Cellular Protein Metabolic Process Movement Of Cell Or Subcellular Component Positive Regulation Of Intracellular Signal Transduction Innate Immune Response Regulation Of Protein Complex Assembly Neuron Differentiation Protein Localization	Regulation Of Voltage-gated Calcium Channel Activity Cellular Response To Light Stimulus Cellular Response To Radiation Cellular Response To Stimulus Response To Stimulus Signal Transduction Response To Metal Ion Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Calcium Ion Transmembrane Transport Regulation Of Calcium Ion Transmembrane Transporter Activity Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Immune System Process Signaling Regulation Of Cation Channel Activity Cell Communication DNA Damage Response, Signal Transduction By P53 Class Mediator Response To Wounding Intracellular Signal Transduction Signal Transduction In Response To DNA Damage Immune Response-regulating Signaling Pathway Response To Inorganic Substance Glycogen Catabolic Process Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Innate Immune Response Cellular Response To Oxygen Levels Signal Transduction By P53 Class Mediator Polysaccharide Catabolic Process Response To Calcium Ion Positive Regulation Of Calcium Ion Transmembrane Transporter Activity Regulation Of DNA Replication Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Growth Factor Stimulus Regulation Of Rhodopsin Mediated Signaling Pathway Immune Response Response To Growth Factor Response To Light Stimulus Energy Reserve Metabolic Process Defense Response Regulation Of Ion Transmembrane Transporter Activity Rhodopsin Mediated Signaling Pathway Cellular Carbohydrate Catabolic Process Regulation Of Transmembrane Transporter Activity Nervous System Development Positive Regulation Of Cation Channel Activity Regulation Of Cellular Process Immune Response-regulating Cell Surface Receptor Signaling Pathway
Tagcloud ?		activating binds canonical clinicopathological coexpression correlating cytoplamic cytoplasm dishevelled dvl embryos expressions growths gtpase localization lymph membranous metastase metastases modulator nodal nsclc nucleus poor prognosis resection wnt xenopus	accessory antigens areas brings cd11c cd40 cd83 cd86 continually cytological dcs dec endocytic initiate interdigitating invariant lymphoid maintains migrate migratory multilectin patch periphery peyer pick recirculate resident speculate uncharacterized
Tagcloud (Difference) ?		activating binds canonical clinicopathological coexpression correlating cytoplamic cytoplasm dishevelled dvl embryos expressions growths gtpase localization lymph membranous metastase metastases modulator nodal nsclc nucleus poor prognosis resection wnt xenopus	accessory antigens areas brings cd11c cd40 cd83 cd86 continually cytological dcs dec endocytic initiate interdigitating invariant lymphoid maintains migrate migratory multilectin patch periphery peyer pick recirculate resident speculate uncharacterized
Tagcloud (Intersection) ?