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PCGF6 and UBE2U
Number of citations of the paper that reports this interaction (PMID
19549727
)
40
Data Source:
BioGRID
(two hybrid)
PCGF6
UBE2U
Gene Name
polycomb group ring finger 6
ubiquitin-conjugating enzyme E2U (putative)
Image
Gene Ontology Annotations
Cellular Component
Nucleus
PcG Protein Complex
PRC1 Complex
Nuclear Chromatin
Cytoplasm
HULC Complex
Molecular Function
RNA Polymerase II Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription
DNA Binding
Sequence-specific DNA Binding Transcription Factor Activity
Protein Binding
Zinc Ion Binding
ATP Binding
Ligase Activity
Ubiquitin-like Protein Transferase Activity
Ubiquitin Protein Ligase Binding
Ubiquitin Protein Ligase Activity
Biological Process
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Transcription, DNA-templated
Negative Regulation Of Transcription, DNA-templated
Protein Polyubiquitination
DNA Repair
Histone Ubiquitination
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Pathways
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions
16 interactors:
BMI1
CBX6
CBX7
CBX8
CDK7
E2F6
HIST3H3
KDM5D
PEX10
RAD18
RING1
RNF2
SS18L1
UBE2U
USP2
USP21
66 interactors:
ANAPC11
BARD1
BFAR
CADPS2
CGRRF1
DTX1
DZIP3
GOLGA2
KAT6A
MDM2
MIB1
MIB2
MID2
MKRN3
MUL1
PCGF1
PCGF2
PCGF6
PJA1
PML
RBCK1
RNF10
RNF11
RNF113A
RNF113B
RNF114
RNF125
RNF139
RNF14
RNF144B
RNF150
RNF166
RNF17
RNF170
RNF181
RNF2
RNF25
RNF26
RNF41
RNF5
RNFT1
SYVN1
TRAIP
TRIM15
TRIM2
TRIM23
TRIM24
TRIM27
TRIM28
TRIM3
TRIM32
TRIM34
TRIM35
TRIM37
TRIM38
TRIM46
TRIM47
TRIM5
TRIM54
TRIM63
TRIM65
TRIM68
TRIM74
VPS11
VPS41
ZSWIM2
Entrez ID
84108
148581
HPRD ID
07427
14599
Ensembl ID
ENSG00000156374
ENSG00000177414
Uniprot IDs
Q9BYE7
Q5VVX9
PDB IDs
2DJB
1YRV
Enriched GO Terms of Interacting Partners
?
Chromatin Modification
Chromosome Organization
Chromatin Organization
Histone Ubiquitination
Histone Modification
Organelle Organization
Negative Regulation Of Gene Expression
Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Transcription, DNA-templated
Negative Regulation Of Transcription From RNA Polymerase II Promoter
RNA Biosynthetic Process
Cellular Nitrogen Compound Metabolic Process
Negative Regulation Of Biosynthetic Process
Protein Ubiquitination
Nitrogen Compound Metabolic Process
Protein Modification By Small Protein Conjugation
Negative Regulation Of Cellular Metabolic Process
Regulation Of Nitrogen Compound Metabolic Process
RNA Metabolic Process
Cellular Protein Modification Process
Regulation Of Transcription From RNA Polymerase II Promoter
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Gene Expression
Regulation Of RNA Metabolic Process
Cellular Macromolecule Biosynthetic Process
Histone H2A Monoubiquitination
Macromolecule Biosynthetic Process
Cellular Metabolic Process
Histone H2A Ubiquitination
Regulation Of Gene Expression
Histone Monoubiquitination
Cellular Protein Metabolic Process
Biosynthetic Process
Protein Monoubiquitination
Regulation Of Metabolic Process
DNA Metabolic Process
Anterior/posterior Pattern Specification
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Proteasomal Protein Catabolic Process
Protein Metabolic Process
Histone H2A-K119 Monoubiquitination
Metabolic Process
Positive Regulation Of Immature T Cell Proliferation In Thymus
Protein Ubiquitination
Protein Modification By Small Protein Conjugation
Cellular Protein Modification Process
Cellular Protein Metabolic Process
Negative Regulation Of Viral Release From Host Cell
Protein Metabolic Process
Regulation Of Viral Release From Host Cell
Protein Polyubiquitination
Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Negative Regulation Of Viral Process
Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Regulation Of Viral Process
Protein Catabolic Process
Positive Regulation Of NF-kappaB Transcription Factor Activity
Protein Autoubiquitination
Proteolysis Involved In Cellular Protein Catabolic Process
Cellular Protein Catabolic Process
Cellular Metabolic Process
Ubiquitin-dependent Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Innate Immune Response
Proteasomal Protein Catabolic Process
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Cellular Macromolecule Catabolic Process
Regulation Of Protein Stability
Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Negative Regulation Of Gene Expression
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Histone H2A Monoubiquitination
Regulation Of Gene Expression
Histone H2A Ubiquitination
Histone H2A-K119 Monoubiquitination
Immune Response
Regulation Of Intracellular Transport
Cellular Process
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Defense Response
Interferon-gamma-mediated Signaling Pathway
Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Histone Monoubiquitination
Negative Regulation Of Cellular Metabolic Process
Regulation Of Viral Entry Into Host Cell
Response To Stress
Negative Regulation Of Viral Transcription
Regulation Of Apoptotic Process
Regulation Of RNA Metabolic Process
Cellular Response To Interferon-gamma
Protein Destabilization
Regulation Of Signal Transduction
Tagcloud
?
attains
cbx3
collaboration
compacted
copresence
e2f6
e2fs
entailing
h2a
hp1gamma
integral
l3mbtl1
l3mbtl2
marks
mblr
mbt
monoubiquitination
necessitated
overlap
polycomb
prc1
prc1l4
rb1
repression
repressive
ring1
ring2
rnai
Tagcloud (Difference)
?
attains
cbx3
collaboration
compacted
copresence
e2f6
e2fs
entailing
h2a
hp1gamma
integral
l3mbtl1
l3mbtl2
marks
mblr
mbt
monoubiquitination
necessitated
overlap
polycomb
prc1
prc1l4
rb1
repression
repressive
ring1
ring2
rnai
Tagcloud (Intersection)
?