PCGF6 and MAGEC2

Number of citations of the paper that reports this interaction (PubMedID 25590999)
60

Data Source:
BioGRID (two hybrid)

		PCGF6	MAGEC2
Description		polycomb group ring finger 6	MAGE family member C2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm PcG Protein Complex PRC1 Complex	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Protein Binding Zinc Ion Binding Metal Ion Binding	Protein Binding Ubiquitin Protein Ligase Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription	Negative Regulation Of Transcription By RNA Polymerase II Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity
Pathways		Transcriptional Regulation by E2F6
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Brain morphology (MOSTest) ( 32665545) Response to cognitive-behavioural therapy in major depressive disorder ( 31123309) Schizophrenia ( 23974872 25056061 29483656)	Antineutrophil cytoplasmic antibody-associated vasculitis ( 22808956) Non-response to bupropion and depression ( 27622933)
Interacting Genes		27 interacting genes: BMI1 CBX6 CBX7 CDK7 E2F6 EIF2B2 H3-4 KDM5D MAGEA1 MAGEC2 MAGEE2 MAGEL2 MYC OGT PEX10 PNMA1 RAD18 RNF2 SS18L1 TRIM14 TRIM55 TRIM63 TULP3 UBE2D3 UBE2U USP2 USP21	15 interacting genes: MDM2 MNAT1 P4HA3 PBX3 PCGF6 RBX1 RNF166 SSX1 SSX2 TAF9 TRAF4 TRIM28 TRIM8 UBR3 ZMYND11
Entrez ID		84108	51438
HPRD ID		07427	06632
Ensembl ID		ENSG00000156374	ENSG00000046774
Uniprot IDs		Q9BYE7	Q9UBF1
PDB IDs		2DJB
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription PRC1 Complex Negative Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Post-translational Protein Modification Nucleus Negative Regulation Of RNA Metabolic Process PcG Protein Complex Regulation Of Primary Metabolic Process Chromatin Organization Regulation Of Gene Expression Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Biosynthetic Process Protein Metabolic Process Ubiquitin Protein Ligase Activity Heterochromatin Protein Modification Process Protein Ubiquitination Regulation Of Metabolic Process RING-like Zinc Finger Domain Binding Protein Modification By Small Protein Conjugation Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Nucleoplasm Negative Regulation Of Biosynthetic Process Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Protein Polyubiquitination Protein Monoubiquitination Positive Regulation Of Ubiquitin-protein Transferase Activity Nuclear Body Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Catabolic Process Proteolysis Chromatin Remodeling Protein Deubiquitination Chromosome Ubiquitin-protein Transferase Activity Macromolecule Metabolic Process Regulation Of Ubiquitin-protein Transferase Activity Proteasomal Protein Catabolic Process Protein Modification By Small Protein Removal Epigenetic Regulation Of Gene Expression Transferase Activity MLL1 Complex	Zinc Ion Binding Ubiquitin Protein Ligase Activity NEDD8 Ligase Activity Regulation Of Primary Metabolic Process Ubiquitin-dependent Protein Catabolic Process Regulation Of DNA-templated Transcription Modification-dependent Protein Catabolic Process Regulation Of RNA Biosynthetic Process Negative Regulation Of Signal Transduction By P53 Class Mediator Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of RNA Metabolic Process Protein Modification By Small Protein Conjugation Proteolysis Involved In Protein Catabolic Process Regulation Of Macromolecule Metabolic Process Metal Ion Binding Regulation Of Nucleobase-containing Compound Metabolic Process Proteasomal Protein Catabolic Process Post-translational Protein Modification Regulation Of Metabolic Process Ubiquitin-protein Transferase Activity Protein Polyubiquitination Suppression Of Viral Release By Host Ubiquitin Protein Ligase Binding SUMO Transferase Activity Protein Ubiquitination Protein Catabolic Process Regulation Of Canonical NF-kappaB Signal Transduction Macromolecule Catabolic Process Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteolysis Regulation Of Protein Catabolic Process Regulation Of Gene Expression Respiratory Gaseous Exchange By Respiratory System Proteolysis Transferase Activity Regulation Of Macromolecule Biosynthetic Process Response To Stress DNA Damage Response Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of Transcription By RNA Polymerase II Regulation Of Proteasomal Protein Catabolic Process Transcription Corepressor Activity Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Response To Formaldehyde Cellular Response To Vitamin B1 Regulation Of Apoptotic Process
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