PCGF6 and KDM5D

Number of citations of the paper that reports this interaction (PubMedID 17320162)
0

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)
HPRD (in vitro)

		PCGF6	KDM5D
Description		polycomb group ring finger 6	lysine demethylase 5D
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm PcG Protein Complex PRC1 Complex	Chromatin Fibrillar Center Nucleus Nucleoplasm
	Molecular Function	Protein Binding Zinc Ion Binding Metal Ion Binding	DNA Binding Protein Binding Zinc Ion Binding Oxidoreductase Activity Histone Demethylase Activity Histone H3K4 Demethylase Activity Histone H3K4me/H3K4me2/H3K4me3 Demethylase Activity Metal Ion Binding Nuclear Androgen Receptor Binding Dioxygenase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription	T Cell Antigen Processing And Presentation Chromatin Organization Chromatin Remodeling Regulation Of DNA-templated Transcription Regulation Of Androgen Receptor Signaling Pathway
Pathways		Transcriptional Regulation by E2F6	HDMs demethylate histones
Drugs			Ascorbic acid
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Brain morphology (MOSTest) ( 32665545) Response to cognitive-behavioural therapy in major depressive disorder ( 31123309) Schizophrenia ( 23974872 25056061 29483656)	Autism ( 32996047)
Interacting Genes		27 interacting genes: BMI1 CBX6 CBX7 CDK7 E2F6 EIF2B2 H3-4 KDM5D MAGEA1 MAGEC2 MAGEE2 MAGEL2 MYC OGT PEX10 PNMA1 RAD18 RNF2 SS18L1 TRIM14 TRIM55 TRIM63 TULP3 UBE2D3 UBE2U USP2 USP21	3 interacting genes: H3-4 PCGF6 PEX14
Entrez ID		84108	8284
HPRD ID		07427	02464
Ensembl ID		ENSG00000156374	ENSG00000012817
Uniprot IDs		Q9BYE7	A0A384MR42 B4E1Y0 Q9BY66
PDB IDs		2DJB	2E6R 2YQE
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription PRC1 Complex Negative Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Post-translational Protein Modification Nucleus Negative Regulation Of RNA Metabolic Process PcG Protein Complex Regulation Of Primary Metabolic Process Chromatin Organization Regulation Of Gene Expression Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Biosynthetic Process Protein Metabolic Process Ubiquitin Protein Ligase Activity Heterochromatin Protein Modification Process Protein Ubiquitination Regulation Of Metabolic Process RING-like Zinc Finger Domain Binding Protein Modification By Small Protein Conjugation Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Nucleoplasm Negative Regulation Of Biosynthetic Process Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Protein Polyubiquitination Protein Monoubiquitination Positive Regulation Of Ubiquitin-protein Transferase Activity Nuclear Body Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Catabolic Process Proteolysis Chromatin Remodeling Protein Deubiquitination Chromosome Ubiquitin-protein Transferase Activity Macromolecule Metabolic Process Regulation Of Ubiquitin-protein Transferase Activity Proteasomal Protein Catabolic Process Protein Modification By Small Protein Removal Epigenetic Regulation Of Gene Expression Transferase Activity MLL1 Complex	Protein Import Into Peroxisome Matrix, Translocation Peroxisome Transport Along Microtubule Protein Import Into Peroxisome Matrix, Docking Peroxisomal Importomer Complex Spermatogonial Cell Division Protein Import Into Peroxisome Matrix, Substrate Release DNA Replication-dependent Chromatin Assembly Protein Transmembrane Transporter Activity Protein Unfolding Protein Import Into Peroxisome Matrix, Receptor Recycling Receptor Recycling Peroxisomal Membrane Transport Microtubule Anchoring Establishment Of Protein Localization To Peroxisome Protein Import Into Peroxisome Matrix Peroxisome Organization Chromatin Remodeling PcG Protein Complex PRC1 Complex Negative Regulation Of Protein Binding Intracellular Protein Transmembrane Transport Chromatin Organization Beta-tubulin Binding Regulation Of Protein Binding Receptor Metabolic Process Condensed Nuclear Chromosome Heterochromatin Protein Monoubiquitination
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