PCGF6 and BMI1

Number of citations of the paper that reports this interaction (PMID 12167161)
8

Data Source:
BioGRID (two hybrid)

		PCGF6	BMI1
Gene Name		polycomb group ring finger 6	BMI1 proto-oncogene, polycomb ring finger
Image
Gene Ontology Annotations	Cellular Component	Nucleus PcG Protein Complex PRC1 Complex	Ubiquitin Ligase Complex Heterochromatin Nucleus Nucleoplasm Cytoplasm Nuclear Body PcG Protein Complex PRC1 Complex
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Zinc Ion Binding	Chromatin Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Sequence-specific DNA Binding RING-like Zinc Finger Domain Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Negative Regulation Of Transcription, DNA-templated	Negative Regulation Of Transcription From RNA Polymerase II Promoter In Utero Embryonic Development DNA Methylation Transcription, DNA-templated Humoral Immune Response Segment Specification Brain Development Regulation Of Gene Expression Histone Acetylation Histone Ubiquitination Rostrocaudal Neural Tube Patterning Hemopoiesis Positive Regulation Of B Cell Proliferation Positive Regulation Of Immature T Cell Proliferation In Thymus Somatic Stem Cell Division Positive Regulation Of Fibroblast Proliferation Embryonic Skeletal System Morphogenesis Positive Regulation Of Ubiquitin-protein Transferase Activity Negative Regulation Of Apoptotic Signaling Pathway
Pathways			Oxidative Stress Induced Senescence Cellular Senescence
Drugs
Diseases
GWAS
Protein-Protein Interactions		16 interactors: BMI1 CBX6 CBX7 CBX8 CDK7 E2F6 HIST3H3 KDM5D PEX10 RAD18 RING1 RNF2 SS18L1 UBE2U USP2 USP21	35 interactors: CBX6 CBX7 CBX8 CSNK2B E2F6 FOXS1 H2AFX HIST2H2AA3 HIST2H2AC HIST3H3 IMMT KAT5 KIAA1377 KMT2A LRIF1 MAPK14 NDEL1 PCGF3 PCGF6 PHC1 PHC2 PTN RING1 RNF114 RNF2 RRM1 SOCS2 TRIM27 TUSC3 UBE2D3 UBE2I USP11 USP7 VPS11 ZBTB16
Entrez ID		84108	648
HPRD ID		07427	01277
Ensembl ID		ENSG00000156374	ENSG00000168283
Uniprot IDs		Q9BYE7	P35226
PDB IDs		2DJB	2H0D 3RPG
Enriched GO Terms of Interacting Partners?		Chromatin Modification Chromosome Organization Chromatin Organization Histone Ubiquitination Histone Modification Organelle Organization Negative Regulation Of Gene Expression Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Transcription, DNA-templated Negative Regulation Of Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Biosynthetic Process Protein Ubiquitination Nitrogen Compound Metabolic Process Protein Modification By Small Protein Conjugation Negative Regulation Of Cellular Metabolic Process Regulation Of Nitrogen Compound Metabolic Process RNA Metabolic Process Cellular Protein Modification Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Gene Expression Regulation Of RNA Metabolic Process Cellular Macromolecule Biosynthetic Process Histone H2A Monoubiquitination Macromolecule Biosynthetic Process Cellular Metabolic Process Histone H2A Ubiquitination Regulation Of Gene Expression Histone Monoubiquitination Cellular Protein Metabolic Process Biosynthetic Process Protein Monoubiquitination Regulation Of Metabolic Process DNA Metabolic Process Anterior/posterior Pattern Specification Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Protein Metabolic Process Histone H2A-K119 Monoubiquitination Metabolic Process Positive Regulation Of Immature T Cell Proliferation In Thymus	Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Protein Ubiquitination Negative Regulation Of Transcription From RNA Polymerase II Promoter Protein Modification By Small Protein Conjugation Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Transcription, DNA-templated Chromatin Organization RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Chromosome Organization Chromatin Modification Histone Ubiquitination Cellular Macromolecule Biosynthetic Process Cellular Protein Modification Process Negative Regulation Of Cellular Metabolic Process Nucleobase-containing Compound Metabolic Process Macromolecule Biosynthetic Process Histone Modification Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Organelle Organization Cellular Nitrogen Compound Metabolic Process RNA Metabolic Process Regulation Of Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Gene Expression Regulation Of RNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cellular Metabolic Process Protein Monoubiquitination Proteasomal Protein Catabolic Process Biosynthetic Process Cellular Protein Metabolic Process Regulation Of Gene Expression Response To Ionizing Radiation Mitotic Cell Cycle Cell Cycle Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Histone H2A Monoubiquitination Histone H2A Ubiquitination Protein Metabolic Process Negative Regulation Of Interleukin-2 Production Histone Monoubiquitination
Tagcloud ?		attains cbx3 collaboration compacted copresence e2f6 e2fs entailing h2a hp1gamma integral l3mbtl1 l3mbtl2 marks mblr mbt monoubiquitination necessitated overlap polycomb prc1 prc1l4 rb1 repression repressive ring1 ring2 rnai	activators coimmunoprecipitate colocalize combs drosophila eed enhancer enx1 esc example extra ezh2 homolog homology hpc2 hybrid interacts melanogaster osteosarcoma pcg polycomb progeny repressors screen trithorax trxg unlike z zeste
Tagcloud (Difference) ?		attains cbx3 collaboration compacted copresence e2f6 e2fs entailing h2a hp1gamma integral l3mbtl1 l3mbtl2 marks mblr mbt monoubiquitination necessitated overlap prc1 prc1l4 rb1 repression repressive ring1 ring2 rnai	activators coimmunoprecipitate colocalize combs drosophila eed enhancer enx1 esc example extra ezh2 homolog homology hpc2 hybrid interacts melanogaster osteosarcoma progeny repressors screen trithorax trxg unlike z zeste
Tagcloud (Intersection) ?		pcg polycomb