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HIST2H2AC and CHFR
Number of citations of the paper that reports this interaction (PMID
21706008
)
13
Data Source:
BioGRID
(enzymatic study)
HIST2H2AC
CHFR
Gene Name
histone cluster 2, H2ac
checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleosome
Nucleus
Extracellular Vesicular Exosome
Nucleus
PML Body
Molecular Function
Molecular_function
DNA Binding
Protein Heterodimerization Activity
Nucleotide Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Zinc Ion Binding
Ligase Activity
Biological Process
Biological_process
Protein Polyubiquitination
Ubiquitin-dependent Protein Catabolic Process
Mitotic Nuclear Division
Mitotic Cell Cycle Checkpoint
Modification-dependent Protein Catabolic Process
Cell Division
Pathways
RNA Polymerase I Chain Elongation
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
Mitotic Prophase
Regulatory RNA pathways
RNA Polymerase I Promoter Clearance
Deposition of new CENPA-containing nucleosomes at the centromere
Cellular Senescence
Signaling by Wnt
HATs acetylate histones
M Phase
Amyloids
NoRC negatively regulates rRNA expression
Packaging Of Telomere Ends
Telomere Maintenance
Nucleosome assembly
RNF mutants show enhanced WNT signaling and proliferation
XAV939 inhibits tankyrase, stabilizing AXIN
DNA methylation
Transcriptional regulation by small RNAs
Meiotic recombination
DNA Damage/Telomere Stress Induced Senescence
Chromosome Maintenance
HDACs deacetylate histones
Chromatin organization
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
RNA Polymerase I Transcription
formation of the beta-catenin:TCF transactivating complex
Meiotic synapsis
Epigenetic regulation of gene expression
Senescence-Associated Secretory Phenotype (SASP)
Negative epigenetic regulation of rRNA expression
PRC2 methylates histones and DNA
Cell Cycle, Mitotic
RMTs methylate histone arginines
Chromatin modifying enzymes
Oxidative Stress Induced Senescence
TCF dependent signaling in response to WNT
RNA Polymerase I Promoter Opening
SIRT1 negatively regulates rRNA Expression
Signaling by WNT in cancer
Condensation of Prophase Chromosomes
Drugs
Diseases
GWAS
Protein-Protein Interactions
65 interactors:
ANP32A
ATXN7L3
BAP1
BARD1
BAZ1B
BMI1
BRCA1
CDY1
CHFR
COPRS
CRP
CTCFL
CTDP1
DDB2
DNMT3L
EIF2AK2
EP300
GATAD2A
GATAD2B
HAT1
HDAC2
HIST1H2BA
HIST1H3A
HIST1H4A
HIST2H2BE
HIST2H4A
KAT2A
KAT2B
KAT5
KAT7
MSL2
MYSM1
NAP1L4
NCAPH
NCL
NPM1
PARP10
PBRM1
PELP1
PRMT5
PRMT7
RAG1
RBBP4
RCC1
RNF168
RNF2
RNF20
RNF8
SART3
SIRT7
SSRP1
TAF15
TAF1A
TAF1B
TCF20
TSPY1
TSSK6
UBC
UBE2B
UBR2
UIMC1
USP12
USP16
USP22
USP46
26 interactors:
AURKA
BRD4
CBLC
EEF1G
GABBR1
HDAC1
HDAC2
HIST2H2AC
HIST2H2BE
ITGAE
PML
RNF125
RNF7
TRIM9
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2E1
UBE2E2
UBE2E3
UBE2I
UBE2N
UBE2V1
UBE2W
WDR47
Entrez ID
8338
55743
HPRD ID
09107
05552
Ensembl ID
ENSG00000184260
ENSG00000072609
Uniprot IDs
Q16777
Q96EP1
PDB IDs
1LGP
1LGQ
2XOC
2XOY
2XOZ
2XP0
Enriched GO Terms of Interacting Partners
?
Chromatin Organization
Chromosome Organization
Chromatin Modification
Histone Modification
Organelle Organization
Regulation Of Gene Expression
Nucleobase-containing Compound Metabolic Process
Regulation Of RNA Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Cellular Protein Modification Process
Regulation Of RNA Biosynthetic Process
Cellular Nitrogen Compound Metabolic Process
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Histone Ubiquitination
Regulation Of Gene Expression, Epigenetic
Regulation Of Nitrogen Compound Metabolic Process
Nitrogen Compound Metabolic Process
DNA Metabolic Process
Transcription, DNA-templated
RNA Biosynthetic Process
Negative Regulation Of Gene Expression
Cellular Protein Metabolic Process
Gene Expression
Chromatin Remodeling
Regulation Of Metabolic Process
Chromatin Silencing
Cellular Metabolic Process
DNA Packaging
Nucleosome Organization
Protein Metabolic Process
Negative Regulation Of Transcription, DNA-templated
Chromatin Assembly Or Disassembly
Negative Regulation Of Nucleic Acid-templated Transcription
Histone H2A Ubiquitination
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Gene Expression, Epigenetic
Histone Acetylation
Nucleosome Assembly
RNA Metabolic Process
Protein-DNA Complex Assembly
Internal Peptidyl-lysine Acetylation
Negative Regulation Of Cellular Metabolic Process
Peptidyl-lysine Acetylation
Internal Protein Amino Acid Acetylation
Negative Regulation Of Biosynthetic Process
Cell Cycle
Histone Deubiquitination
Chromatin Assembly
Protein Ubiquitination
Protein Modification By Small Protein Conjugation
Protein Polyubiquitination
Protein K48-linked Ubiquitination
Cellular Protein Modification Process
Ubiquitin-dependent Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Proteolysis Involved In Cellular Protein Catabolic Process
Cellular Protein Catabolic Process
Cellular Protein Metabolic Process
Protein Catabolic Process
Protein K11-linked Ubiquitination
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Proteasomal Protein Catabolic Process
Protein K63-linked Ubiquitination
Cellular Macromolecule Catabolic Process
Protein Metabolic Process
Toll-like Receptor 4 Signaling Pathway
Toll-like Receptor Signaling Pathway
Cellular Response To Stress
Proteolysis
Pattern Recognition Receptor Signaling Pathway
Innate Immune Response-activating Signal Transduction
Negative Regulation Of Cell Cycle
Activation Of Innate Immune Response
Catabolic Process
Innate Immune Response
Positive Regulation Of Innate Immune Response
Histone Modification
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Response To Stress
Regulation Of Mitotic Cell Cycle Phase Transition
Regulation Of Cell Cycle
Regulation Of Mitotic Cell Cycle
Regulation Of Cell Cycle Phase Transition
Regulation Of Innate Immune Response
Chromatin Organization
Mitotic Cell Cycle
Regulation Of Cell Cycle Process
Regulation Of Response To DNA Damage Stimulus
Protein Monoubiquitination
Positive Regulation Of Proteolysis
Transforming Growth Factor Beta Receptor Signaling Pathway
ISG15-protein Conjugation
Cellular Response To DNA Damage Stimulus
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress
Fungiform Papilla Formation
Regulation Of DNA-templated Transcription In Response To Stress
Chromatin Modification
Regulation Of Organelle Organization
Tagcloud
?
adeno
adenocarcinoma
adenocarcinomas
alk
atlas
biomarker
correlates
datasets
egfr
erbb2
exon19
fgfr1
fgfr2
fgfr3
kras
nf1
pik3ca
powerful
predictor
project
ret
ros1
seq
squamous
stk11
taxane
tcga
tp53
utilized
Tagcloud (Difference)
?
adeno
adenocarcinoma
adenocarcinomas
alk
atlas
biomarker
correlates
datasets
egfr
erbb2
exon19
fgfr1
fgfr2
fgfr3
kras
nf1
pik3ca
powerful
predictor
project
ret
ros1
seq
squamous
stk11
taxane
tcga
tp53
utilized
Tagcloud (Intersection)
?