CHFR and GABBR1

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		CHFR	GABBR1
Gene Name		checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase	gamma-aminobutyric acid (GABA) B receptor, 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus PML Body	Extracellular Region Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Cell Junction Dendrite G-protein Coupled Receptor Heterodimeric Complex Presynaptic Membrane Postsynaptic Membrane
	Molecular Function	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity	G-protein Coupled GABA Receptor Activity Protein Binding
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Mitotic Nuclear Division Mitotic Cell Cycle Checkpoint Modification-dependent Protein Catabolic Process Cell Division	Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Gamma-aminobutyric Acid Signaling Pathway Synaptic Transmission
Pathways			Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Inwardly rectifying K+ channels GABA B receptor activation Signaling by GPCR GABA receptor activation Activation of G protein gated Potassium channels Activation of GABAB receptors Potassium Channels Metabolic disorders of biological oxidation enzymes GPCR ligand binding G protein gated Potassium channels Class C/3 (Metabotropic glutamate/pheromone receptors) GPCR downstream signaling G alpha (i) signalling events Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits Transmission across Chemical Synapses
Drugs			Baclofen Progabide Vigabatrin
Diseases
GWAS			Crohn's disease ( 22412388) Nasopharyngeal carcinoma ( 19664746)
Protein-Protein Interactions		26 interactors: AURKA BRD4 CBLC EEF1G GABBR1 HDAC1 HDAC2 HIST2H2AC HIST2H2BE ITGAE PML RNF125 RNF7 TRIM9 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2I UBE2N UBE2V1 UBE2W WDR47	11 interactors: ATF5 CHFR GABBR2 GNAO1 JAKMIP1 KCNJ6 MAX NSF RGS4 UBC YWHAZ
Entrez ID		55743	2550
HPRD ID		05552	04644
Ensembl ID		ENSG00000072609	ENSG00000204681
Uniprot IDs		Q96EP1	Q5SUJ9 Q8IW08 Q9UBS5
PDB IDs		1LGP 1LGQ 2XOC 2XOY 2XOZ 2XP0
Enriched GO Terms of Interacting Partners?		Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein Polyubiquitination Protein K48-linked Ubiquitination Cellular Protein Modification Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Cellular Protein Metabolic Process Protein Catabolic Process Protein K11-linked Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Protein K63-linked Ubiquitination Cellular Macromolecule Catabolic Process Protein Metabolic Process Toll-like Receptor 4 Signaling Pathway Toll-like Receptor Signaling Pathway Cellular Response To Stress Proteolysis Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Negative Regulation Of Cell Cycle Activation Of Innate Immune Response Catabolic Process Innate Immune Response Positive Regulation Of Innate Immune Response Histone Modification Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Response To Stress Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Phase Transition Regulation Of Innate Immune Response Chromatin Organization Mitotic Cell Cycle Regulation Of Cell Cycle Process Regulation Of Response To DNA Damage Stimulus Protein Monoubiquitination Positive Regulation Of Proteolysis Transforming Growth Factor Beta Receptor Signaling Pathway ISG15-protein Conjugation Cellular Response To DNA Damage Stimulus Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Fungiform Papilla Formation Regulation Of DNA-templated Transcription In Response To Stress Chromatin Modification Regulation Of Organelle Organization
Tagcloud ?		adeno adenocarcinoma adenocarcinomas alk atlas biomarker correlates datasets egfr erbb2 exon19 fgfr1 fgfr2 fgfr3 kras nf1 pik3ca powerful predictor project ret ros1 seq squamous stk11 taxane tcga tp53 utilized
Tagcloud (Difference) ?		adeno adenocarcinoma adenocarcinomas alk atlas biomarker correlates datasets egfr erbb2 exon19 fgfr1 fgfr2 fgfr3 kras nf1 pik3ca powerful predictor project ret ros1 seq squamous stk11 taxane tcga tp53 utilized
Tagcloud (Intersection) ?