CHFR and UBE2W

Number of citations of the paper that reports this interaction (PMID 19549727)
40

Data Source:
BioGRID (two hybrid)

		CHFR	UBE2W
Gene Name		checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase	ubiquitin-conjugating enzyme E2W (putative)
Image
Gene Ontology Annotations	Cellular Component	Nucleus PML Body	Nucleus Cytoplasm
	Molecular Function	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity	Ubiquitin-protein Transferase Activity ATP Binding Ligase Activity Ubiquitin-like Protein Transferase Activity Ubiquitin Protein Ligase Binding Ubiquitin Protein Ligase Activity
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Mitotic Nuclear Division Mitotic Cell Cycle Checkpoint Modification-dependent Protein Catabolic Process Cell Division	DNA Repair Protein Monoubiquitination Misfolded Or Incompletely Synthesized Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K11-linked Ubiquitination Cellular Response To Misfolded Protein
Pathways			Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		26 interactors: AURKA BRD4 CBLC EEF1G GABBR1 HDAC1 HDAC2 HIST2H2AC HIST2H2BE ITGAE PML RNF125 RNF7 TRIM9 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2I UBE2N UBE2V1 UBE2W WDR47	69 interactors: AKR1C3 AMFR BARD1 BFAR BIRC2 BIRC8 BRCA1 CADPS2 CHFR CNOT4 DNMT3B DTX3 DTX3L DZIP3 EED FANCL LRSAM1 MAP3K1 MARCH3 MARCH5 MGRN1 MIB1 MID1 MKRN1 MKRN3 MUL1 PJA2 POLR2C PSTPIP1 RFWD3 RMND5B RNF10 RNF103 RNF111 RNF114 RNF115 RNF123 RNF125 RNF138 RNF14 RNF150 RNF152 RNF165 RNF166 RNF167 RNF185 RNF2 RNF26 RNF4 RNF5 RNF8 ROPN1 STUB1 TOPORS TRIM17 TRIM2 TRIM27 TRIM31 TRIM35 TRIM39 TRIM8 UBA1 UBOX5 UFM1 UHRF2 USHBP1 XIAP ZNRF1 ZNRF4
Entrez ID		55743	55284
HPRD ID		05552	07724
Ensembl ID		ENSG00000072609	ENSG00000104343
Uniprot IDs		Q96EP1	Q96B02 Q96FI0
PDB IDs		1LGP 1LGQ 2XOC 2XOY 2XOZ 2XP0	2A7L
Enriched GO Terms of Interacting Partners?		Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein Polyubiquitination Protein K48-linked Ubiquitination Cellular Protein Modification Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Cellular Protein Metabolic Process Protein Catabolic Process Protein K11-linked Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Protein K63-linked Ubiquitination Cellular Macromolecule Catabolic Process Protein Metabolic Process Toll-like Receptor 4 Signaling Pathway Toll-like Receptor Signaling Pathway Cellular Response To Stress Proteolysis Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Negative Regulation Of Cell Cycle Activation Of Innate Immune Response Catabolic Process Innate Immune Response Positive Regulation Of Innate Immune Response Histone Modification Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Response To Stress Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Phase Transition Regulation Of Innate Immune Response Chromatin Organization Mitotic Cell Cycle Regulation Of Cell Cycle Process Regulation Of Response To DNA Damage Stimulus Protein Monoubiquitination Positive Regulation Of Proteolysis Transforming Growth Factor Beta Receptor Signaling Pathway ISG15-protein Conjugation Cellular Response To DNA Damage Stimulus Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Fungiform Papilla Formation Regulation Of DNA-templated Transcription In Response To Stress Chromatin Modification Regulation Of Organelle Organization	Protein Modification By Small Protein Conjugation Protein Ubiquitination Cellular Protein Modification Process Protein Polyubiquitination Cellular Protein Metabolic Process Protein Metabolic Process Protein Autoubiquitination Cellular Metabolic Process Protein K48-linked Ubiquitination Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein K63-linked Ubiquitination Cellular Macromolecule Catabolic Process Ubiquitin-dependent Protein Catabolic Process Metabolic Process Cellular Response To Stress Catabolic Process Protein Monoubiquitination Response To Stress Cellular Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Viral Release From Host Cell Proteasomal Protein Catabolic Process Protein K6-linked Ubiquitination Regulation Of Protein Ubiquitination Cellular Response To DNA Damage Stimulus Inhibition Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Protein Ubiquitination Negative Regulation Of Viral Release From Host Cell DNA Repair Negative Regulation Of Viral Transcription Proteolysis Apoptotic Process Regulation Of Gene Expression By Genetic Imprinting Regulation Of Viral Transcription Programmed Cell Death Negative Regulation Of Viral Process Regulation Of Viral Process Cell Death Death Positive Regulation Of Organelle Organization Genetic Imprinting Positive Regulation Of Protein Modification Process Regulation Of Organelle Organization Ubiquitin-dependent SMAD Protein Catabolic Process Positive Regulation Of Histone Methylation Histone Ubiquitination Cellular Response To Stimulus
Tagcloud ?		adeno adenocarcinoma adenocarcinomas alk atlas biomarker correlates datasets egfr erbb2 exon19 fgfr1 fgfr2 fgfr3 kras nf1 pik3ca powerful predictor project ret ros1 seq squamous stk11 taxane tcga tp53 utilized	advance amines chemically cleave cleaving deubiquitylating displaying dub dubs fusions homopolymers hydrolase isopeptide k11 l3 linkage linkages mono monoubiquitylation preference reversal striking sumo2 synthesised topologically ubiquitylation uch unstructured
Tagcloud (Difference) ?		adeno adenocarcinoma adenocarcinomas alk atlas biomarker correlates datasets egfr erbb2 exon19 fgfr1 fgfr2 fgfr3 kras nf1 pik3ca powerful predictor project ret ros1 seq squamous stk11 taxane tcga tp53 utilized	advance amines chemically cleave cleaving deubiquitylating displaying dub dubs fusions homopolymers hydrolase isopeptide k11 l3 linkage linkages mono monoubiquitylation preference reversal striking sumo2 synthesised topologically ubiquitylation uch unstructured
Tagcloud (Intersection) ?