CHFR and ITGAE

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		CHFR	ITGAE
Gene Name		checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase	integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus PML Body	Plasma Membrane Integrin Complex External Side Of Plasma Membrane
	Molecular Function	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity	Metal Ion Binding
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Mitotic Nuclear Division Mitotic Cell Cycle Checkpoint Modification-dependent Protein Catabolic Process Cell Division	Cell Adhesion Integrin-mediated Signaling Pathway Extracellular Matrix Organization
Pathways			Integrin cell surface interactions
Drugs
Diseases
GWAS			Attention deficit hyperactivity disorder ( 18839057)
Protein-Protein Interactions		26 interactors: AURKA BRD4 CBLC EEF1G GABBR1 HDAC1 HDAC2 HIST2H2AC HIST2H2BE ITGAE PML RNF125 RNF7 TRIM9 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2I UBE2N UBE2V1 UBE2W WDR47	4 interactors: CDH1 CHFR EED ITGB7
Entrez ID		55743	3682
HPRD ID		05552	05249
Ensembl ID		ENSG00000072609	ENSG00000083457
Uniprot IDs		Q96EP1	P38570
PDB IDs		1LGP 1LGQ 2XOC 2XOY 2XOZ 2XP0
Enriched GO Terms of Interacting Partners?		Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein Polyubiquitination Protein K48-linked Ubiquitination Cellular Protein Modification Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Cellular Protein Metabolic Process Protein Catabolic Process Protein K11-linked Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Protein K63-linked Ubiquitination Cellular Macromolecule Catabolic Process Protein Metabolic Process Toll-like Receptor 4 Signaling Pathway Toll-like Receptor Signaling Pathway Cellular Response To Stress Proteolysis Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Negative Regulation Of Cell Cycle Activation Of Innate Immune Response Catabolic Process Innate Immune Response Positive Regulation Of Innate Immune Response Histone Modification Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Response To Stress Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Phase Transition Regulation Of Innate Immune Response Chromatin Organization Mitotic Cell Cycle Regulation Of Cell Cycle Process Regulation Of Response To DNA Damage Stimulus Protein Monoubiquitination Positive Regulation Of Proteolysis Transforming Growth Factor Beta Receptor Signaling Pathway ISG15-protein Conjugation Cellular Response To DNA Damage Stimulus Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Fungiform Papilla Formation Regulation Of DNA-templated Transcription In Response To Stress Chromatin Modification Regulation Of Organelle Organization	Protein Polyubiquitination Cell-matrix Adhesion Involved In Ameboidal Cell Migration Cell Cycle Checkpoint Cellular Response To Indole-3-methanol Mitotic Nuclear Division Activation Of Anaphase-promoting Complex Activity Salivary Gland Cavitation Protein Localization To Membrane Extracellular Matrix Organization Extracellular Structure Organization Positive Regulation Of Histone H3-K27 Methylation Cell Division Regulation Of Histone H3-K27 Methylation Leukocyte Tethering Or Rolling Negative Regulation Of Cell Aging Ubiquitin-dependent Protein Catabolic Process T Cell Migration Modification-dependent Protein Catabolic Process Regulation Of Branching Involved In Salivary Gland Morphogenesis Intestinal Epithelial Cell Development Single Organismal Cell-cell Adhesion Cellular Response To Lithium Ion Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Regulation Of Protein Localization To Cell Surface Regulation Of Water Loss Via Skin Protein Ubiquitination Intestinal Epithelial Cell Differentiation Heterotypic Cell-cell Adhesion Protein K11-linked Ubiquitination Protein Modification By Small Protein Conjugation Protein Catabolic Process Trophectodermal Cell Differentiation Regulation Of Gene Expression By Genetic Imprinting Lymphocyte Migration Mitotic Cell Cycle Process Cellular Extravasation Response To Lithium Ion Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Cell Morphogenesis Involved In Differentiation Mitotic Cell Cycle G2 DNA Damage Checkpoint Genetic Imprinting Lens Fiber Cell Differentiation Positive Regulation Of Histone Methylation Positive Regulation Of Transcription Factor Import Into Nucleus Blastocyst Formation Viral Entry Into Host Cell Regulation Of Meiosis Entry Into Host Cell
Tagcloud ?		adeno adenocarcinoma adenocarcinomas alk atlas biomarker correlates datasets egfr erbb2 exon19 fgfr1 fgfr2 fgfr3 kras nf1 pik3ca powerful predictor project ret ros1 seq squamous stk11 taxane tcga tp53 utilized	angptl4 atp5d atp5g3 atp5j2 atp5l ccnb1 cdc10 cdc20 cdc23 dyn efemp1 eng epas1 fbn1 fn1 hcaecs hmox1 itga5 itgav lamr1 lgals3 loxl2 lss p4hb pgk1 pkd2 sage vasodilatory vasoreactive
Tagcloud (Difference) ?		adeno adenocarcinoma adenocarcinomas alk atlas biomarker correlates datasets egfr erbb2 exon19 fgfr1 fgfr2 fgfr3 kras nf1 pik3ca powerful predictor project ret ros1 seq squamous stk11 taxane tcga tp53 utilized	angptl4 atp5d atp5g3 atp5j2 atp5l ccnb1 cdc10 cdc20 cdc23 dyn efemp1 eng epas1 fbn1 fn1 hcaecs hmox1 itga5 itgav lamr1 lgals3 loxl2 lss p4hb pgk1 pkd2 sage vasodilatory vasoreactive
Tagcloud (Intersection) ?