BRD3 and SPP1

Number of citations of the paper that reports this interaction (PMID 22779921)
1

Data Source:
BioGRID (two hybrid)

		BRD3	SPP1
Gene Name		bromodomain containing 3	secreted phosphoprotein 1
Image
Gene Ontology Annotations	Cellular Component	Nucleus	Extracellular Region Extracellular Space Cell Projection Apical Part Of Cell Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Chromatin Binding Protein Binding Lysine-acetylated Histone Binding	Cytokine Activity Protein Binding Extracellular Matrix Binding
	Biological Process	Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Chromatin Modification	Osteoblast Differentiation Inflammatory Response Cell Adhesion Embryo Implantation Positive Regulation Of Cell-substrate Adhesion Extracellular Matrix Disassembly Extracellular Matrix Organization Neutrophil Chemotaxis Biomineral Tissue Development Response To Vitamin D Positive Regulation Of Bone Resorption Decidualization Response To Steroid Hormone Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury
Pathways			Signaling by PDGF Integrin cell surface interactions Degradation of the extracellular matrix
Drugs
Diseases
GWAS		Platelet counts ( 22139419)	Dental caries ( 23064961)
Protein-Protein Interactions		6 interactors: APP BRD7 MAP1LC3B MYC SPP1 SRPK2	88 interactors: ABCF3 ACP5 AFF4 AMOTL2 APOA1 ATP2A2 ATP5F1 BAG6 BRD3 C1RL C2orf50 CACNG4 CALM1 CC2D1B CD44 CEP162 CHD1 CISD2 CMTM3 COMMD1 COPS5 CSNK2A1 CSNK2A2 CTNNBL1 CYB5R3 DCX DNAJB1 DNTTIP2 DSEL EEF1A1 EIF3K EPAS1 F2 FTH1 GRIPAP1 HBA2 HMGN1 IGFBP5 ITGA5 ITGA9 ITGAV ITGB1 KCNIP1 LRRC4 MAP1A MAP1B MARCKS MEOX2 MMP3 MMP7 MPPED1 MRPL23 NACA NCKAP1 NCSTN PDLIM7 PEMT PEPD PLD3 PRKACB PRKCA PRKG1 RANBP9 RAPGEF2 RBBP6 RIMS4 RPL13 RPL15 RPL5 RPS13 SEC24C SGTA SLC39A6 SNAPIN SSB STAU1 STK39 TBC1D8 TMEM168 TMEM30A TPT1 TTC1 TUBB UBQLN4 USP42 USP8 ZNF638 ZNF804A
Entrez ID		8019	6696
HPRD ID		03327	01325
Ensembl ID		ENSG00000169925	ENSG00000118785
Uniprot IDs		Q15059	B7Z351 P10451 Q3LGB0
PDB IDs		2E7N 2NXB 2OO1 2YW5 3S91 3S92	3CXD 3DSF
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Cycle Positive Regulation Of Gene Expression Positive Regulation Of Metanephric Cap Mesenchymal Cell Proliferation Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Nuclear Speck Organization Response To Stress Cellular Response To Stimulus Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Synaptic Growth At Neuromuscular Junction Fibroblast Apoptotic Process Notch Signaling Pathway Negative Regulation Of Cell Differentiation Positive Regulation Of Peptidase Activity Transition Metal Ion Homeostasis Collateral Sprouting In Absence Of Injury Negative Regulation Of Neuron Differentiation Regulation Of Chromosome Organization Collateral Sprouting Axon Midline Choice Point Recognition Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Negative Regulation Of Monocyte Differentiation Negative Regulation Of Collateral Sprouting Axon Choice Point Recognition Positive Regulation Of Cell Proliferation Involved In Kidney Development Response To Stimulus Negative Regulation Of Axon Regeneration Positive Regulation Of Cellular Protein Metabolic Process Wnt Signaling Pathway Positive Regulation Of Cell Cycle Regulation Of Developmental Growth Negative Regulation Of Neurogenesis Positive Regulation Of Proteolysis Neuron Remodeling Positive Regulation Of Protein Metabolic Process Negative Regulation Of Cell Development Response To Light Stimulus Positive Regulation Of Transcription, DNA-templated Defense Response Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Monocyte Differentiation Regulation Of Endopeptidase Activity Regulation Of Cellular Amino Acid Metabolic Process RNA Metabolic Process Cell Communication Positive Regulation Of Bone Resorption Regulation Of Cell Proliferation Cellular Metal Ion Homeostasis	Wound Healing Blood Coagulation Hemostasis Movement Of Cell Or Subcellular Component Neuron Projection Development Response To Wounding Chemotaxis Locomotion Membrane Organization Cell Projection Organization Axon Development Neuron Development Developmental Process Regulation Of Body Fluid Levels Cellular Localization Extracellular Matrix Organization Regulation Of Proteasomal Protein Catabolic Process Extracellular Structure Organization Chemical Homeostasis Anatomical Structure Development Axon Guidance Axonogenesis System Development Leukocyte Migration Translational Initiation Viral Process Ion Homeostasis Regulation Of Cellular Process Nervous System Development Multicellular Organismal Development Cell Migration Neuron Differentiation Metal Ion Homeostasis Cell Morphogenesis Involved In Neuron Differentiation Translational Elongation Immune System Process Integrin-mediated Signaling Pathway Viral Life Cycle Anatomical Structure Morphogenesis Cell Motility Homeostatic Process Neuron Projection Morphogenesis Heterotypic Cell-cell Adhesion Response To Stress Generation Of Neurons Regulation Of Cellular Protein Metabolic Process Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cell Development Regulation Of Protein Metabolic Process
Tagcloud ?		acquired bet breast classic degrader effort epigenomic eralpha estrogen facilitates frontline fulvestrant h3k36 jq1 lasting methyltransferase modifiers potently premenopausal recruited regulator regulators screen sirna tam tamoxifen valid whsc1 xenograft	able acquisition acts carcinomas cbx7 chemokine contributing counteracts decreases encoding fact hmga1b inducing interacting interferes involves malignant member modulation osteopontin played polycomb progressively relation repressive suppose take transcriptional whose
Tagcloud (Difference) ?		acquired bet breast classic degrader effort epigenomic eralpha estrogen facilitates frontline fulvestrant h3k36 jq1 lasting methyltransferase modifiers potently premenopausal recruited regulator regulators screen sirna tam tamoxifen valid whsc1 xenograft	able acquisition acts carcinomas cbx7 chemokine contributing counteracts decreases encoding fact hmga1b inducing interacting interferes involves malignant member modulation osteopontin played polycomb progressively relation repressive suppose take transcriptional whose
Tagcloud (Intersection) ?