BRD3 and SPP1

Number of citations of the paper that reports this interaction (PubMedID 22779921)
0

Data Source:
BioGRID (two hybrid)

		BRD3	SPP1
Description		bromodomain containing 3	secreted phosphoprotein 1
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GO Annotations	Cellular Component	Chromatin Nucleus Chromosome	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Golgi Apparatus Vesicle Cell Projection Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Chromatin Binding Protein Serine/threonine Kinase Activity Protein Binding Protein-macromolecule Adaptor Activity Histone Binding Histone H3K9me2/3 Reader Activity LncRNA Binding Histone H3K18cr Reader Activity Histone H3K9cr Reader Activity Histone H3K27cr Reader Activity Histone Reader Activity Molecular Condensate Scaffold Activity	Cytokine Activity Integrin Binding Protein Binding Small Molecule Binding Extracellular Matrix Binding
	Biological Process	Chromatin Organization Chromatin Remodeling Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Endodermal Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Protein Localization To Chromatin	Ossification Osteoblast Differentiation Androgen Catabolic Process Cell Adhesion Signal Transduction Embryo Implantation Cell Differentiation Biomineral Tissue Development Response To Vitamin D Response To Macrophage Colony-stimulating Factor Positive Regulation Of Bone Resorption Positive Regulation Of DNA-templated Transcription Decidualization Response To Steroid Hormone Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Cellular Response To Testosterone Stimulus Response To 2,3,7,8-tetrachlorodibenzodioxine Positive Regulation Of Estradiol Secretion
Pathways			Degradation of the extracellular matrix Signaling by PDGF Integrin cell surface interactions Integrin cell surface interactions Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) RUNX3 Regulates Immune Response and Cell Migration Post-translational protein phosphorylation Mechanical load activates signaling by PIEZO1 and integrins in osteocytes
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 34315874) Alcohol consumption (drinks per week) ( 30643258) Apolipoprotein A1 levels ( 32203549) Aspartate aminotransferase levels ( 34315874) Brain-derived neurotrophic factor levels ( 33345186) Central corneal thickness ( 31798171 29760442) Cerebrospinal fluid t-tau levels in normal cognition ( 29274321) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Eosinophil count ( 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252 32888494) Estimated glomerular filtration rate ( 31152163) Granulocyte percentage of myeloid white cells ( 27863252) HDL cholesterol levels ( 32203549) Immature fraction of reticulocytes ( 32888494) Intraocular pressure ( 29617998 30591961) Lymphocyte count ( 32888494) Mean platelet volume ( 27863252 32888494) Mosquito bite size ( 28199695) Neutrophil count ( 27863252 32888494) Neutrophil percentage of granulocytes ( 27863252) Neutrophil percentage of white cells ( 32888494 27863252) Platelet count ( 32888494 22139419) Platelet distribution width ( 27863252) Red cell distribution width ( 28957414 32888494 27863252) Sum basophil neutrophil counts ( 27863252) Sum eosinophil basophil counts ( 27863252)	Blood protein levels ( 30072576) Dental caries ( 23064961) Gout ( 33832965) Urate levels ( 31578528)
Interacting Genes		6 interacting genes: APP BRD7 MAP1LC3B MYC SPOP SPP1	97 interacting genes: ABCF3 ACP5 AFF4 AMOTL2 APOA1 ATP2A2 ATP5PB BAG6 BRD3 C1RL CACNG4 CALM1 CC2D1B CCR8 CD44 CEP162 CHD1 CIMIP5 CISD2 CMTM3 COMMD1 COPS5 CSNK2A1 CSNK2A2 CTNNBL1 CYB5R3 DCX DNAJB1 DNTTIP2 DRD2 DSEL EEF1A1 EIF3K EPAS1 ERBB2 F2 FTH1 GET3 GRIPAP1 HBA2 HMGN1 IGFBP5 ITGA5 ITGA9 ITGAV ITGB1 ITGB5 KCNIP1 LRRC4 MAP1A MAP1B MARCKS MEOX2 MMP3 MMP7 MPPED1 MRPL23 NACA NCKAP1 NCS1 NCSTN PDLIM7 PEMT PEPD PLD3 PRKACB PRKCA PRKG1 PTGER4 RANBP9 RAPGEF2 RBBP6 RIMS4 RPL13 RPL15 RPL5 RPS13 SEC24C SGTA SGTB SLC22A1 SLC39A6 SNAPIN SSB STAU1 STK39 TBC1D8 TMEM168 TMEM30A TPT1 TTC1 TUBB UBQLN4 USP42 USP8 ZNF638 ZNF804A
Entrez ID		8019	6696
HPRD ID		03327	01325
Ensembl ID		ENSG00000169925	ENSG00000118785
Uniprot IDs		Q15059	B7Z351 P10451 Q3LGB0
PDB IDs		2E7N 2NXB 2OO1 2YW5 3S91 3S92 5A7C 5HFR 5HJC 6BGG 6BGH 6I41 6I5P 6I68 6I7A 6QJU 6U4A 6ULP 7JMY 7JQ8 7JYN 7JYZ 7L72 7L9L 7LAY 7LAZ 7LB4 7LBT 7R8R 7RJK 7RJL 7RJM 7RJN 7S3P 7TO7 7TO8 7TO9 7TOA 7UG5 8B5A 8CV5	3CXD 3DSF 9EOU
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Gene Expression, Epigenetic Amyloid-beta Complex Growth Cone Lamellipodium Epigenetic Regulation Of Gene Expression Regulation Of Response To Calcium Ion Regulation Of MiRNA Transcription Perinuclear Region Of Cytoplasm Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Cellular Response To Stress Striated Muscle Cell Differentiation Positive Regulation Of Metanephric Cap Mesenchymal Cell Proliferation Ubiquitin Protein Ligase Binding Acinar Cell Proliferation Positive Regulation Of Acinar Cell Proliferation SCF Ubiquitin Ligase Complex Binding Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Memory T Cell Differentiation Regulation Of Cell Cycle Adult Locomotory Behavior Acetylcholine Receptor Activator Activity Protein-folding Chaperone Binding Regulation Of Cellular Component Organization PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Associative Learning Regulation Of MiRNA Metabolic Process Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Response To Peptide Response To Cytokine Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Leukocyte Activation Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization NK T Cell Proliferation Myc-Max Complex Muscle Cell Differentiation Regulation Of Acinar Cell Proliferation Positive Regulation Of Estradiol Secretion Regulation Of Estradiol Secretion Response To Nutrient Levels TSC1-TSC2 Complex Response To Norepinephrine Integrin Binding Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway	Cytosol Modulation Of Chemical Synaptic Transmission Wound Healing, Spreading Of Cells Regulation Of Ubiquitin-dependent Protein Catabolic Process Integrin Complex Wound Healing, Spreading Of Epidermal Cells Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Biological Quality Microtubule Associated Complex Regulation Of Protein Metabolic Process Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Lamellipodium Membrane Regulation Of Proteolysis Extracellular Exosome Integrin-mediated Signaling Pathway Cell-matrix Adhesion Negative Regulation Of Proteolysis Negative Regulation Of Proteasomal Protein Catabolic Process Integrin Alpha5-beta1 Complex Cell Adhesion Mediated By Integrin Integrin Alpha9-beta1 Complex Integrin Alphav-beta5 Complex Integrin Alphav-beta1 Complex Ribosomal Subunit TRC Complex Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Focal Adhesion Response To Stress Endodermal Cell Differentiation Developmental Process Negative Regulation Of Protein Catabolic Process Regulation Of System Process Protein Kinase CK2 Complex Alphav-beta3 Integrin-PKCalpha Complex Dendritic Microtubule Tail-anchored Membrane Protein Insertion Into ER Membrane Monoatomic Cation Transport Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Calcium Channel Regulator Activity Metal Ion Transport Regulation Of Proteasomal Protein Catabolic Process Regulation Of Synaptic Plasticity Regulation Of Protein Neddylation Biological_process Translation Dendritic Spine Cytosolic Ribosome Ruffle Membrane Cell-substrate Adhesion
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