BRD3 and MYC

Number of citations of the paper that reports this interaction (PMID 20195357)
18

Data Source:
BioGRID (pull down)

		BRD3	MYC
Gene Name		bromodomain containing 3	v-myc avian myelocytomatosis viral oncogene homolog
Image
Gene Ontology Annotations	Cellular Component	Nucleus	Nucleus Nucleoplasm Nucleolus Cytosol Protein Complex
	Molecular Function	Chromatin Binding Protein Binding Lysine-acetylated Histone Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Factor Binding Protein Complex Binding Protein Dimerization Activity Repressing Transcription Factor Binding E-box Binding
	Biological Process	Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Chromatin Modification	Negative Regulation Of Transcription From RNA Polymerase II Promoter MAPK Cascade Branching Involved In Ureteric Bud Morphogenesis Positive Regulation Of Mesenchymal Cell Proliferation Energy Reserve Metabolic Process Chromatin Remodeling Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Cellular Iron Ion Homeostasis Cellular Response To DNA Damage Stimulus Cell Cycle Arrest Transforming Growth Factor Beta Receptor Signaling Pathway Notch Signaling Pathway Positive Regulation Of Cell Proliferation Response To Gamma Radiation Gene Expression Regulation Of Gene Expression Oxygen Transport Regulation Of Telomere Maintenance Negative Regulation Of Stress-activated MAPK Cascade Cellular Response To UV Cellular Response To Drug Response To Drug Negative Regulation Of Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Fibroblast Apoptotic Process Negative Regulation Of Monocyte Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Fibroblast Proliferation Negative Regulation Of Fibroblast Proliferation Positive Regulation Of Epithelial Cell Proliferation Chromosome Organization Negative Regulation Of Cell Division Canonical Wnt Signaling Pathway Response To Growth Factor Positive Regulation Of Metanephric Cap Mesenchymal Cell Proliferation Positive Regulation Of DNA Biosynthetic Process Positive Regulation Of Response To DNA Damage Stimulus
Pathways			Loss of Function of TGFBR2 in Cancer Signaling by NOTCH1 HD Domain Mutants in Cancer Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer SMAD2/3 MH2 Domain Mutants in Cancer Signaling by Wnt Cyclin E associated events during G1/S transition binding of TCF/LEF:CTNNB1 to target gene promoters TGFBR1 LBD Mutants in Cancer SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Generic Transcription Pathway RNF mutants show enhanced WNT signaling and proliferation G1/S Transition Signaling by NOTCH1 XAV939 inhibits tankyrase, stabilizing AXIN Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Mitotic G1-G1/S phases FBXW7 Mutants and NOTCH1 in Cancer TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling Loss of Function of SMAD2/3 in Cancer Signaling by NOTCH formation of the beta-catenin:TCF transactivating complex TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer S Phase Cell Cycle, Mitotic Loss of Function of TGFBR1 in Cancer NOTCH1 Intracellular Domain Regulates Transcription Signaling by TGF-beta Receptor Complex in Cancer Signaling by TGF-beta Receptor Complex TCF dependent signaling in response to WNT Signaling by NOTCH1 PEST Domain Mutants in Cancer Cyclin A:Cdk2-associated events at S phase entry Signaling by WNT in cancer Constitutive Signaling by NOTCH1 PEST Domain Mutants SMAD4 MH2 Domain Mutants in Cancer
Drugs
Diseases
GWAS		Platelet counts ( 22139419)	Bladder cancer ( 20972438) Breast cancer ( 23535729) Colorectal cancer ( 23266556) Multiple sclerosis ( 21833088) Ovarian cancer ( 23535730 20852632) Urinary bladder cancer ( 20348956 18794855)
Protein-Protein Interactions		6 interactors: APP BRD7 MAP1LC3B MYC SPP1 SRPK2	126 interactors: ACTL6A ATAD2 AXIN1 BCL2 BIN1 BRCA1 BRD3 BTRC CCNH CCNT1 CDC6 CDCA7L CDK1 CDK4 CDK6 CDK8 CDKN2A CEBPA CEBPB CEP57 CREB1 CREBBP CSNK2A1 CSNK2A2 DNMT3A EFNB1 ELF3 EP300 EP400 FBXO8 FBXW7 FBXW8 GCN1L1 GPX2 GSK3A GSK3B GTF2B GTF2F1 GTF2I HNRNPD HSP90AA1 HUWE1 ING4 KAT2A KAT2B KAT5 KDM1A KIAA1524 KIDINS220 KPNA2 LDOC1 MAP2K1 MAPK1 MAPK3 MAPK7 MAPK8 MAX MED1 MED12 MED14 MED16 MEN1 MINA MLH1 MOK MXD1 MXI1 MYCBP MYCBP2 NEK11 NFYB NFYC NMI NOTCH3 NUCB1 PAK2 PARP10 PFDN5 PLAU PML POLR2A PRDX1 PSMC3 RAF1 RB1 RBL1 RELA RUVBL1 SAP130 SF3B1 SKP1 SKP2 SMAD2 SMAD3 SMARCA2 SMARCA4 SMARCB1 SMARCC1 SNIP1 SNRNP70 SP1 SPAG9 SUPT3H TADA2A TAF1B TAF5 TAF9 TBP TFAP2A TFAP2B TIAM1 TONSL TP73 TRIM6 TRRAP TUBA1A TUBA1B TUBA3C TUBA4A TUBA8 UBB USP37 YEATS4 YY1 ZBTB17 ZNF281
Entrez ID		8019	4609
HPRD ID		03327	01818
Ensembl ID		ENSG00000169925	ENSG00000136997
Uniprot IDs		Q15059	P01106
PDB IDs		2E7N 2NXB 2OO1 2YW5 3S91 3S92	1A93 1EE4 1MV0 1NKP 2A93 2OR9
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Cycle Positive Regulation Of Gene Expression Positive Regulation Of Metanephric Cap Mesenchymal Cell Proliferation Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Nuclear Speck Organization Response To Stress Cellular Response To Stimulus Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Synaptic Growth At Neuromuscular Junction Fibroblast Apoptotic Process Notch Signaling Pathway Negative Regulation Of Cell Differentiation Positive Regulation Of Peptidase Activity Transition Metal Ion Homeostasis Collateral Sprouting In Absence Of Injury Negative Regulation Of Neuron Differentiation Regulation Of Chromosome Organization Collateral Sprouting Axon Midline Choice Point Recognition Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Negative Regulation Of Monocyte Differentiation Negative Regulation Of Collateral Sprouting Axon Choice Point Recognition Positive Regulation Of Cell Proliferation Involved In Kidney Development Response To Stimulus Negative Regulation Of Axon Regeneration Positive Regulation Of Cellular Protein Metabolic Process Wnt Signaling Pathway Positive Regulation Of Cell Cycle Regulation Of Developmental Growth Negative Regulation Of Neurogenesis Positive Regulation Of Proteolysis Neuron Remodeling Positive Regulation Of Protein Metabolic Process Negative Regulation Of Cell Development Response To Light Stimulus Positive Regulation Of Transcription, DNA-templated Defense Response Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Monocyte Differentiation Regulation Of Endopeptidase Activity Regulation Of Cellular Amino Acid Metabolic Process RNA Metabolic Process Cell Communication Positive Regulation Of Bone Resorption Regulation Of Cell Proliferation Cellular Metal Ion Homeostasis	Regulation Of Nitrogen Compound Metabolic Process Transcription, DNA-templated Positive Regulation Of Gene Expression Regulation Of RNA Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Gene Expression RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Cellular Aromatic Compound Metabolic Process Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Heterocycle Metabolic Process Cellular Nitrogen Compound Metabolic Process Cellular Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Nitrogen Compound Metabolic Process DNA-templated Transcription, Initiation Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase II Promoter Viral Process Regulation Of Cellular Process Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Cell Cycle Negative Regulation Of Biosynthetic Process Cell Cycle Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Chromatin Modification Negative Regulation Of Gene Expression Cellular Response To Stress Mitotic Cell Cycle Histone Acetylation Negative Regulation Of Transcription, DNA-templated Chromatin Organization Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Regulation Of Cell Cycle Internal Protein Amino Acid Acetylation
Tagcloud ?		acquired bet breast classic degrader effort epigenomic eralpha estrogen facilitates frontline fulvestrant h3k36 jq1 lasting methyltransferase modifiers potently premenopausal recruited regulator regulators screen sirna tam tamoxifen valid whsc1 xenograft	augment augments bait cbp coactivator coil coiled enhances except hybrid ifngamma instead interactor interacts interestingly intrinsic lacks nmi potentiate recruitment reveal screen stat stat1 stat2 stat5 stat5b stats yeast
Tagcloud (Difference) ?		acquired bet breast classic degrader effort epigenomic eralpha estrogen facilitates frontline fulvestrant h3k36 jq1 lasting methyltransferase modifiers potently premenopausal recruited regulator regulators sirna tam tamoxifen valid whsc1 xenograft	augment augments bait cbp coactivator coil coiled enhances except hybrid ifngamma instead interactor interacts interestingly intrinsic lacks nmi potentiate recruitment reveal stat stat1 stat2 stat5 stat5b stats yeast
Tagcloud (Intersection) ?		screen