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CDC73 and CEP70
Number of citations of the paper that reports this interaction (PMID
21900206
)
27
Data Source:
BioGRID
(two hybrid, two hybrid)
CDC73
CEP70
Gene Name
cell division cycle 73
centrosomal protein 70kDa
Image
No pdb structure
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleus
Nucleoplasm
Cdc73/Paf1 Complex
Nucleoplasm
Cytoplasm
Centrosome
Cytosol
Nuclear Membrane
Molecular Function
RNA Polymerase II Core Binding
Protein Binding
Protein Binding
Biological Process
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Endodermal Cell Fate Commitment
Transcription, DNA-templated
MRNA Polyadenylation
Cell Cycle
Negative Regulation Of Cell Proliferation
Histone Monoubiquitination
Wnt Signaling Pathway
Stem Cell Maintenance
Positive Regulation Of Wnt Signaling Pathway
Positive Regulation Of MRNA 3'-end Processing
Protein Destabilization
Positive Regulation Of Transcription Elongation From RNA Polymerase II Promoter
Histone H2B Ubiquitination
Negative Regulation Of Myeloid Cell Differentiation
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Negative Regulation Of Fibroblast Proliferation
Negative Regulation Of Epithelial Cell Proliferation
Cellular Response To Lipopolysaccharide
Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
G2/M Transition Of Mitotic Cell Cycle
Mitotic Cell Cycle
Organelle Organization
Pathways
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
TCF dependent signaling in response to WNT
RNF mutants show enhanced WNT signaling and proliferation
Hedgehog 'on' state
formation of the beta-catenin:TCF transactivating complex
XAV939 inhibits tankyrase, stabilizing AXIN
Signaling by Hedgehog
Signaling by Wnt
Signaling by WNT in cancer
Organelle biogenesis and maintenance
Loss of proteins required for interphase microtubule organization from the centrosome
Loss of Nlp from mitotic centrosomes
G2/M Transition
Assembly of the primary cilium
Centrosome maturation
Regulation of PLK1 Activity at G2/M Transition
Mitotic G2-G2/M phases
Anchoring of the basal body to the plasma membrane
Recruitment of mitotic centrosome proteins and complexes
Cell Cycle, Mitotic
Drugs
Diseases
GWAS
Subcutaneous adipose tissue (
22589738
)
Protein-Protein Interactions
30 interactors:
ALAS1
ANXA6
CCDC155
CEP70
CTNNB1
DDAH2
FAF1
FSD2
GC
GOLGA2
HAP1
HIST1H1C
HSF2BP
HSPA4
ITFG1
KCNH2
KIAA1549
KIDINS220
MCM3AP
MTUS2
PITHD1
RNF20
RNF40
TCEA1
TCF4
TFCP2
TOMM20
TSGA10
VPS37B
WWC1
134 interactors:
ABT1
AKAP17A
ARHGEF3
ATP5O
ATXN7
BARD1
BEX2
BRMS1
BYSL
C11orf57
C1orf35
C7orf25
C8orf33
CARD9
CCDC85B
CCDC94
CDC73
CDCA7L
CEP57L1
CFAP53
CLPB
COIL
DAZAP2
DDX41
DDX6
DIEXF
DNAJB11
EMD
EMP1
ENKD1
ERCC3
FAM118B
FAM124A
FAM133A
FAM13C
FAM161A
FAM214B
FAM64A
GATAD2B
GCC1
GPATCH2L
GPATCH4
GPX7
HAUS1
HMGB4
HSPD1
IK
IQCE
KANK2
KANSL1
KAT7
KDM1A
KRT31
LAMTOR5
LENG1
LENG8
LIN37
MCM10
MEST
METTL17
MFAP1
MRPL44
NIPSNAP3A
NKAP
NOL12
NOP2
NRIP1
NUSAP1
PAM16
PLA2G2A
PPFIA1
PPIG
PPP1R16B
PRKRIP1
PRPF31
PSMA1
RCOR3
RPL13
SERPINH1
SETD5
SFR1
SH2D4A
SLU7
SMARCE1
SNRPD2
SRGN
SSX3
STK25
STMN2
SUV39H1
SUV39H2
SYT17
SYTL4
SYTL5
TAF1D
TCEB3
TCEB3B
TEAD4
TRIM29
TRIM42
TSGA10IP
TSHZ3
TTC25
TTLL10
TXLNB
UTP11L
UTP14A
ZBTB16
ZBTB24
ZBTB49
ZBTB8A
ZCCHC10
ZFC3H1
ZGPAT
ZNF136
ZNF148
ZNF169
ZNF227
ZNF239
ZNF266
ZNF302
ZNF329
ZNF366
ZNF408
ZNF410
ZNF417
ZNF426
ZNF439
ZNF490
ZNF555
ZNF572
ZNF578
ZNF587
ZSCAN12
Entrez ID
79577
80321
HPRD ID
09581
16779
Ensembl ID
ENSG00000134371
ENSG00000114107
Uniprot IDs
Q6P1J9
B7Z2D2
Q8NHQ1
PDB IDs
Enriched GO Terms of Interacting Partners
?
Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition
Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process
Histone H2B Ubiquitination
Cellular Localization
Positive Regulation Of Glycoprotein Biosynthetic Process
Establishment Of Localization In Cell
Genitalia Morphogenesis
Positive Regulation Of Glycoprotein Metabolic Process
Organelle Organization
Histone Monoubiquitination
Regulation Of Glycoprotein Biosynthetic Process
Establishment Of Protein Localization To Organelle
Protein Localization
Chromosome Organization
Histone Ubiquitination
Protein Import
Positive Regulation Of Epithelial To Mesenchymal Transition
Cellular Process
Cytoplasmic Transport
Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway
Positive Regulation Of Histone Methylation
Intracellular Transport
Positive Regulation Of Neurogenesis
Positive Regulation Of Cellular Metabolic Process
Negative Regulation Of Organ Growth
Organelle Localization
Transcription-coupled Nucleotide-excision Repair
Regulation Of Oligodendrocyte Differentiation
Protein Targeting
Protein Monoubiquitination
Myoblast Differentiation
Regulation Of Intracellular Transport
Positive Regulation Of Neurotrophin Production
Positive Regulation Of Nonmotile Primary Cilium Assembly
Chromosome Localization To Nuclear Envelope Involved In Synapsis
Negative Regulation Of Potassium Ion Export
Regulation Of Myelination
Positive Regulation Of Intracellular Signal Transduction
Skin Morphogenesis
Vesicle Localization
Regulation Of Histone Methylation
Positive Regulation Of Stem Cell Differentiation
Positive Regulation Of Signal Transduction
Positive Regulation Of Cell Development
Genitalia Development
Regulation Of Intracellular Signal Transduction
Skin Development
Regulation Of Epithelial To Mesenchymal Transition
Protein Localization To Organelle
Protein Transmembrane Transport
RNA Metabolic Process
Gene Expression
Nucleobase-containing Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Nitrogen Compound Metabolic Process
RNA Biosynthetic Process
Transcription, DNA-templated
Macromolecule Biosynthetic Process
Cellular Macromolecule Biosynthetic Process
Regulation Of Transcription, DNA-templated
Regulation Of RNA Metabolic Process
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Biosynthetic Process
Regulation Of Nitrogen Compound Metabolic Process
Regulation Of Gene Expression
Regulation Of Metabolic Process
Cellular Metabolic Process
Cellular Process
Negative Regulation Of Cellular Metabolic Process
Negative Regulation Of Gene Expression
Negative Regulation Of Transcription, DNA-templated
Ribonucleoprotein Complex Biogenesis
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Negative Regulation Of Biosynthetic Process
RRNA Processing
Regulation Of Cellular Process
RRNA Metabolic Process
Ribosomal Small Subunit Biogenesis
Regulation Of Transcription From RNA Polymerase II Promoter
Chromatin Modification
MRNA Metabolic Process
Metabolic Process
Ribosome Biogenesis
Histone H3-K9 Dimethylation
RNA Processing
Chromatin Organization
Histone Modification
Maturation Of SSU-rRNA
Chromosome Organization
Cell Death
Death
Histone H3-K9 Trimethylation
Peptidyl-lysine Dimethylation
Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway
Apoptotic Process
Tagcloud
?
1379delt
affecting
caucasian
encoded
fibroma
hpt
hyperparathyroidism
hystologically
instrumental
jaw
jt
l460lfs
mandible
modelling
moiety
mtt
ossifying
parafibromin
parathyroid
partners
proband
pth
relatives
sanger
sca
silico
terminus
underlie
vast
Tagcloud (Difference)
?
1379delt
affecting
caucasian
encoded
fibroma
hpt
hyperparathyroidism
hystologically
instrumental
jaw
jt
l460lfs
mandible
modelling
moiety
mtt
ossifying
parafibromin
parathyroid
partners
proband
pth
relatives
sanger
sca
silico
terminus
underlie
vast
Tagcloud (Intersection)
?