CDC73 and USP12

Number of citations of the paper that reports this interaction (PubMedID 35742816)
38

Data Source:
BioGRID (pull down)

		CDC73	USP12
Description		cell division cycle 73	ubiquitin specific peptidase 12
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm Cytosol Cdc73/Paf1 Complex	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane
	Molecular Function	RNA Polymerase II Complex Binding Protein Binding	Cysteine-type Endopeptidase Activity Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Metal Ion Binding Deubiquitinase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Growth Endodermal Cell Fate Commitment Regulation Of Transcription By RNA Polymerase II Transcription Elongation By RNA Polymerase II Negative Regulation Of Cell Population Proliferation Wnt Signaling Pathway Stem Cell Population Maintenance Positive Regulation Of Wnt Signaling Pathway MRNA 3'-end Processing Positive Regulation Of MRNA 3'-end Processing Protein Destabilization Positive Regulation Of Transcription Elongation By RNA Polymerase II Negative Regulation Of Apoptotic Process Negative Regulation Of Myeloid Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Fibroblast Proliferation Negative Regulation Of Epithelial Cell Proliferation Cellular Response To Lipopolysaccharide Positive Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle	Proteolysis Protein Deubiquitination Regulation Of Protein Stability
Pathways		Formation of RNA Pol II elongation complex Formation of the beta-catenin:TCF transactivating complex Hedgehog 'on' state RNA Polymerase II Pre-transcription Events RNA Polymerase II Transcription Elongation E3 ubiquitin ligases ubiquitinate target proteins	Ub-specific processing proteases
Drugs
Diseases		Primary hyperparathyroidism; Familial hyperparathyroidism (HRPT)
GWAS		Chronotype ( 30696823) High density lipoprotein cholesterol levels ( 34074324) Ovarian disease with few adhesions ( 28333195) Photic sneeze reflex ( 27182965) Subcutaneous adipose tissue ( 22589738) Takayasu arteritis ( 25604533) White matter hyperintensity burden ( 25663218)	Alcohol dependence ( 21314694) Anti-saccade response ( 29064472) Aspartate aminotransferase levels ( 33547301) Mortality in sepsis ( 27639821) Nose morphology ( 29921221) Ulcerative colitis ( 19915573)
Interacting Genes		45 interacting genes: ALAS1 ANXA6 CEP70 CLTCL1 CTNNB1 DDAH2 DES DMPK EEA1 FAF1 FHL2 FSD2 GC GOLGA2 GOLGA6L9 H1-2 HAP1 HSF2BP HSPA4 ITFG1 KASH5 KCNH2 KIAA1549 KIDINS220 MCM3AP MTUS2 MYC PICK1 PITHD1 PTPN11 RABEP1 RNF20 RNF40 TCEA1 TCF4 TFCP2 TOMM20 TRIM23 TSGA10 USP12 USP15 USP25 USP28 VPS37B WWC1	9 interacting genes: APP BAX CDC73 H2AC20 H2BC21 HMGB1 NOTCH1 RRM2 UBC
Entrez ID		79577	219333
HPRD ID		09581	15631
Ensembl ID		ENSG00000134371	ENSG00000152484
Uniprot IDs		Q6P1J9	O75317
PDB IDs		5YDE 5YDF 6TED 7OOP 7OPC 7OPD 7UNC 7UND 8A3Y 9EGX 9EGY 9EGZ 9EH0 9EH2	5K16 5K1A 5K1B 5K1C 5L8W
Enriched GO Terms of Interacting Partners?		Deubiquitinase Activity Ubiquitin Protein Ligase Binding Beta-catenin-TCF7L2 Complex Neurotrophin Signaling Pathway HULC Complex Cysteine-type Deubiquitinase Activity Identical Protein Binding Protein Deubiquitination Fascia Adherens Protein Modification By Small Protein Removal	Apoptotic Process Involved In Embryonic Digit Morphogenesis Positive Regulation Of Apoptotic Process Involved In Development Positive Regulation Of Apoptotic Process Involved In Morphogenesis RAGE Receptor Binding Response To External Biotic Stimulus Protein Heterodimerization Activity Regulation Of Epithelial Cell Proliferation Nucleus Positive Regulation Of Monocyte Chemotaxis Apoptotic Process Involved In Morphogenesis Positive Regulation Of Apoptotic Process Chemoattractant Activity Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Monocyte Chemotaxis Apoptotic Process Involved In Development Epithelial Cell Proliferation Negative Regulation Of Fibroblast Proliferation Inflammatory Response To Antigenic Stimulus Positive Regulation Of Programmed Cell Death Regulation Of Chemotaxis Homeostasis Of Number Of Cells Within A Tissue Positive Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Hematopoietic Progenitor Cell Differentiation Positive Chemotaxis Negative Regulation Of Cell Population Proliferation Amyloid-beta Complex Growth Cone Lamellipodium Chromatin Remodeling Epigenetic Regulation Of Gene Expression Regulation Of Response To Calcium Ion Macrophage Activation Regulation Of ERK1 And ERK2 Cascade Amylin Binding Antibacterial Humoral Response Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Interleukin-1 Beta Production Humoral Immune Response T Cell Homeostatic Proliferation BAX Complex Release Of Matrix Enzymes From Mitochondria Calcium-dependent Protein Kinase Regulator Activity Regulation Of Restriction Endodeoxyribonuclease Activity Negative Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Myeloid Progenitor Cell Differentiation Positive Regulation Of Viral Process Notch Signaling Pathway Involved In Regulation Of Secondary Heart Field Cardioblast Proliferation Venous Endothelial Cell Differentiation Coronary Sinus Valve Morphogenesis Foregut Morphogenesis Positive Regulation Of Cell Cycle G1/S Phase Transition
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